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Method for preparing acetyl hexapeptide-8 containing penetration enhancing anti-wrinkle essence preparation

An acetyl hexapeptide and penetration-promoting technology, which is applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of low peptide action efficiency and restricted penetration, so as to improve transparency and active ingredient penetration, and promote Good skin penetration and stability

Active Publication Date: 2019-11-29
杭州梵琳科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to effectively act on the skin, acetyl hexapeptide-8 must reach the target site in sufficient concentration, and the considerable barrier properties of the skin itself limit its penetration in the skin, and the efficiency of the peptide to reach the target site of the skin is reduced

Method used

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  • Method for preparing acetyl hexapeptide-8 containing penetration enhancing anti-wrinkle essence preparation
  • Method for preparing acetyl hexapeptide-8 containing penetration enhancing anti-wrinkle essence preparation
  • Method for preparing acetyl hexapeptide-8 containing penetration enhancing anti-wrinkle essence preparation

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0034] The preparation method of the acetyl hexapeptide of example 1, liposome coating:

[0035] 1), according to acetyl hexapeptide-8 solution: total lipid (lecithin + cholesterol) = 3:10, cholesterol: lecithin = 1:6, emulsifier (Tween 20): total lipid = 1:30 , Lecithin: mass ratio of ethanol=1:20, first weigh lecithin, cholesterol, ethanol and Tween 20, place in a beaker, mix evenly, until obtaining the solution of homogeneous system.

[0036] The concentration of acetyl hexapeptide-8 in the acetyl hexapeptide-8 solution is 1000ppm;

[0037]Cholesterol and lecithin are conventional known substances, for example, cholesterol is CAS: 57-88-5;

[0038] 2) Place the beaker in an ultrasonic cleaning machine for about 15 minutes of conventional ultrasonication to make the system more uniformly dispersed. Subsequently, the mixture was evaporated under reduced pressure (0.1 MPa pressure) for about 15 minutes at 60° C. to remove ethanol. When a uniform film is formed on the wall o...

Embodiment 1

[0041] 100g raw material consists of the following components by weight: 0.02g Carbomer U2020, 3g 1,3-Butanediol, 4g Glycerin, 0.02g Sodium Hyaluronate, 3g Methyl Glucose-10, 2g Polyvinyl Alcohol, 0.1g disodium edetate, 0.012g nicotinamide, 0.5g aminomethyl propanol, 0.5g 1,2-hexanediol, 0.5g hydroxyapatite, 1g acetyl hexapeptide-8 solution (containing 1000ppm acetyl hexapeptide-8), the balance is water (that is, the consumption of water is 85.348g);

[0042] The preparation method is as follows:

[0043] 1) Weigh 0.02g of Carbomer U2020, dissolve it in 3g of 1,3-butanediol and 4g of glycerin, and stir until there are no lumps.

[0044] 2) Weigh 0.02g of sodium hyaluronate, 3g of methyl glucose-10, 2g of polyvinyl alcohol and 0.1g of disodium ethylenediaminetetraacetate and dissolve them in 85.348g of water, add the resultant from step 1) and mix well , heated to 80°C and then evenly stirred and mixed for 20 minutes (to ensure no agglomeration);

[0045] 3) Cool the result ...

Embodiment 2

[0047] 1) Weigh 0.02g of Carbomer U2020, dissolve it in 3g of 1,3-butanediol and 4g of glycerin, and stir until there are no lumps.

[0048] 2) Weigh 0.02g of sodium hyaluronate, 3g of methyl glucose-10, 2g of polyvinyl alcohol and 0.1g of disodium ethylenediaminetetraacetate and dissolve them in 83.348g of water, add the resultant from step 1) and mix well , heated to 80°C and then evenly stirred and mixed for 20 minutes (to ensure no agglomeration);

[0049] 3) Cool the product obtained in step 2) to 70°C, and add 0.012g of nicotinamide. While continuing to cool to 60° C., 0.5 g of aminomethylpropanol, 0.5 g of 1,2-hexanediol and 0.5 g of hydroxyapatite were added. When continuing to cool below 45°C, add 3g of acetyl hexapeptide-8 solution (containing 1000ppm acetyl hexapeptide-8), stir well to obtain the essence preparation.

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Abstract

The invention discloses a method for preparing an acetyl hexapeptide-8 containing penetration enhancing anti-wrinkle essence preparation. The preparation consists of ingredients of Carbopol U2020, 1,3-butanediol, glycerinum, sodium hyaluronate, methyl gluceth-10, polyvinyl alcohol, ethylene diamine tetraacetic acid, nicotinamide, aminomethyl propanol, 1,2-hexanediol, hydroxyapatite, a chemical penetration enhancer, an acetyl hexapeptide-8 solution or acetyl hexapeptide which is prepared from the acetyl hexapeptide-8 solution and is coated by lipidosome, and water. The anti-wrinkle essence preparation prepared by using the method is capable of further promoting skin penetration of acetyl hexapeptide-8.

Description

technical field [0001] The invention belongs to the field of cosmetic essence, and in particular relates to a preparation method of an anti-wrinkle essence preparation which uses acetyl hexapeptide-8 as the main active ingredient, adopts penetration enhancer pentanediol, EPDM147 and liposome coating to enhance penetration. Background technique [0002] As an active ingredient with high activity, natural availability, selective mode of action and low incidence of side effects, cosmetic peptides can effectively fight skin aging, and their use in cosmetics has been growing steadily. [0003] Acetyl hexapeptide-8, as a well-known ingredient in anti-aging products, is mainly used in cosmetics to lighten expression lines. It is also a neurotransmitter inhibitory peptide, which reduces muscle contraction by inhibiting the release of the neurotransmitter acetylcholine, thereby reducing the generation of dynamic lines and expression lines. It has a mechanism of action similar to tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/24A61K8/34A61K8/40A61K8/44A61K8/64A61K8/67A61K8/73A61K8/81A61K8/86A61K8/63A61K8/55A61Q19/08
CPCA61K8/64A61K8/345A61K8/735A61K8/86A61K8/8129A61K8/44A61K8/675A61K8/40A61K8/24A61K8/63A61K8/553A61K8/14A61Q19/08
Inventor 叶琳琳王舒月
Owner 杭州梵琳科技有限公司
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