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A multi-block polymer, its synthesis method and fluorescent probe for tumor detection

A synthesis method and technology of fluorescent probes, which can be applied in fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems such as biological fluorescent probes that have not yet appeared, and achieve good supramolecular assembly characteristics and biocompatibility. Effect

Active Publication Date: 2021-09-24
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Aggregation-induced luminescence is a promising bioluminescence probe technology, but there is no aggregation-induced luminescence bioluminescence probe that can effectively detect cancer cells or tissues in response to carbon dioxide stimulation

Method used

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  • A multi-block polymer, its synthesis method and fluorescent probe for tumor detection
  • A multi-block polymer, its synthesis method and fluorescent probe for tumor detection
  • A multi-block polymer, its synthesis method and fluorescent probe for tumor detection

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Embodiment 1

[0051] Multi-block polymer, such as figure 1 As shown, its synthesis method includes the following steps:

[0052] (1) Synthesis of 1- (4-hydroxyphenyl) -1,2,2-triphenylideylene (Tpe-OH): 250ml flask with zinc (12.8 g) and tetrahydrofuran (200 mL) is placed in ice In the water bath, the system temperature is stable in the range of 0 to 10 ° C, and 10.4 ml of TiCl is slowly added with a constant pressure drip ball. 4 Subsequently, the ice water bath was removed, and the resulting mixture was refluxed by 2.5 h; after cooling to room temperature, 4 ml of pyridine was slowly added to the flask; 2.0 g of diphenyl ketone and 2.0 g of 4-hydroxybenzophenone were dissolved in 20 ml. In tetrahydrofuran, a mixed solution is obtained, and then the mixed solution is slowly added to the flask; the resulting mixture is refluxed, and after cooling to room temperature, add K 2 CO 3 The solution was terminated, and the solvent was removed; the residue was added to water, extracted twice with dichlo...

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Abstract

The invention discloses a multi-block polymer, its synthesis method and a fluorescent probe for tumor detection. The multi-block polymer is a carbon dioxide stimulus-responsive multi-block polymer with good supramolecular assembly characteristics and biocompatibility properties, it can form a polymer assembly after absorbing carbon dioxide, and there is an aggregation-induced luminescence phenomenon, which emits bright blue light under the irradiation of high-energy light (such as ultraviolet light); and nitrogen gas can make the multi-block polymer composition The size of the supramolecular assembly returns to before absorbing carbon dioxide, and the blue light disappears. Therefore, the multi-block polymer of the present invention can be applied to make fluorescent probes for tumor detection, so as to be used for fluorescent diagnosis of cancer cells or tissues.

Description

Technical field [0001] The present invention relates to the field of biotechnology, and more particularly to a multi-block polymer and a synthetic method thereof and a fluorescent probe for tumor detection. Background technique [0002] Optical probe imaging has high selectivity, high resolution, non-invasive, real-time, is an important and rapidly developing research area, which encourages the continuous cooperation between chemists, biologists and clinicians to further improve optics. Probes, diagnosis, treatment, and interventional surgery for cancer. Carbon dioxide is an important gas molecular metabolite produced by a tricarboxylic acid cycle (energy metabolic pathway) during cell aerobic respiration, and cellular carbon dioxide is directly reflected in the activity of intracellular tricarboxylic acid circulation. . Tumor cells have higher metabolic rates than normal cells, both higher carbon dioxide generation rates. Therefore, the carbon dioxide content in the surrounding ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F293/00C08F8/32C08F8/30C09K11/06G01N21/64
CPCC08F8/32C08F2438/03C09K11/06C09K2211/1425C09K2211/1466G01N21/6486C08F8/30C08F293/005
Inventor 王耀周国富
Owner SOUTH CHINA NORMAL UNIVERSITY