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Simulated biofilm and preparation method and application thereof

A biofilm and biosurface technology, applied in the field of simulated biofilm and its preparation, can solve the problems of decreased solubility and elongation, and achieve the effects of low cost, excellent tension and tensile strength, and excellent appearance

Inactive Publication Date: 2019-12-10
陈祥海 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, as the degree of polymerization increases, the viscosity of the aqueous solution increases, and the strength and solvent resistance after film formation increase, but the solubility in water decreases, and the elongation after film formation decreases.

Method used

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  • Simulated biofilm and preparation method and application thereof
  • Simulated biofilm and preparation method and application thereof
  • Simulated biofilm and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1 A kind of simulation biofilm, formula comprises the raw material of following percentage:

[0049] Film former 5-90%

[0050] Biosurfactant 1-25%

[0051] Plasticizer 0.1-5%

[0052] Compatibility release agent 0.5-7%

[0053] Water-based preservative 0.1-3%

[0054] Foaming agent 0.5-6%

[0055] Anti-sticking agent 0-5%

[0056] Auxiliary surfactant combination 0-15%

[0057] Active ingredient 0-30%.

[0058] A simulated biological film, the film-forming agent is one or more polymers capable of forming a continuous film; polymers include but are not limited to polyvinyl alcohol PVA, polyethylene oxide, hydroxyethyl cellulose and both one or more combinations. The polyvinyl alcohol adopts partially hydrogenated polyvinyl alcohol, and its film-forming effect is better, and the polyvinyl alcohol with a dynamic viscosity between 3-60 mPa·s (mPa·s) is more suitable for the use of the product of the present invention. The polyvinyl alcohol film-forming ...

Embodiment 2

[0071] Embodiment 2 A kind of simulated biofilm, formula comprises the raw material of following weight portion:

[0072] 72 parts of film forming agent

[0073] Biosurfactant 18 parts

[0074] 4 parts plasticizer

[0075] 1 part anti-sticking agent

[0076] A simulated biological film, the film-forming agent is a combination of polyvinyl alcohol and water-soluble starch with a mass ratio of 11:4.

[0077] A simulated biofilm, the biosurfactant is a combination of sophorolipid and rhamnolipid with a mass ratio of 13:1.

[0078] A simulated biological film, the plasticizer is a combination of ethylene glycol, polyethylene glycol and glycerol, and the mass ratio is 3:1:4.

[0079] A simulated biological film, the anti-sticking agent is a release agent, and the release agent is simethicone.

[0080] A simulated biological film, adding tackifiers, fillers, adhesives, lubricants, other surfactants, preservatives, coloring agents, wetting agents, spices, flavoring agents, penet...

Embodiment 3

[0081] Embodiment 3 A kind of preparation method of simulated biofilm, drying step is completed in two steps:

[0082] (1) The solution is heated from 40°C to 60°C, and the heating time does not exceed 7 minutes;

[0083] (2) In the second step, the solution completed in the first step is heated to 80-90° C., and the heating time is no more than 30 minutes;

[0084] (3) Curing step: the temperature is 20-60° C., the relative humidity is 60-90%, and the water-soluble, fat-soluble or water-fat-soluble glue solution is dried and solidified through a multi-zone drying tunnel.

[0085] A method for preparing a simulated biological film, the water-soluble, fat-soluble or water-fat-compatible glue solution is poured or cast on a substrate, and then enters a drying room to dry and solidify the water-soluble glue solution; the substrate is : Non-woven fiber products or cotton.

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Abstract

The invention discloses a simulated biofilm and a preparation method and application thereof. The simulated biofilm is prepared from the following raw materials in percentage: 5-90% of a film formingagent, 1-25% of a biosurfactant, 0.1-5% of a plasticizer, 0-5% of an anti-adhesion agent, 0-15% of auxiliary surfactant combination and 0-30% of active ingredients. The simulated biofilm has the advantages that water solubility and fat solubility are both achieved; products with different purposes can be prepared by adding different ingredients and adjusting the proportion of the ingredients, theaffinity with human tissues and clothing fabrics is good, irritation is small, a larger contact area can be better formed, the function efficiency of the containing active ingredients is improved, drug delivery is increased, the cleaning effectiveness of a detergent is improved, the use amount of the active ingredients such as drugs is decreased, and thus the cost is lowered.

Description

technical field [0001] The patent of the present invention relates to the technical field of water-soluble films, in particular to a simulated biological film and its preparation method and application. Background technique [0002] Biofilm (Biofilm) is a film-like structure formed by polysaccharide protein complexes such as polysaccharide protein, polysaccharide matrix, fibrin, and lipoprotein secreted by microorganisms when they gather at solid-liquid or gas-liquid interfaces. Its molecular shape includes a hydrophilic polar head and a hydrophobic fatty acyl chain tail. This amphiphilic property maintains the stability of the membrane structure. Biofilms are attached matrices of bacteria irreversibly attached to surfaces of inert or living entities. When the biofilm is exposed to adverse environments such as sub-inhibitory concentrations of antibacterial drugs or metal ions, it can induce the expression of genes encoding extracellular polymeric substances (EPS) component...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L29/04C08L3/02C08L71/02C08K5/053C08J5/18
CPCC08J5/18C08J2329/04C08J2403/02C08J2471/02C08K5/053
Inventor 陈祥海于海成赵少华陈汉超马球
Owner 陈祥海
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