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Grosvenor momordica fruit extract with obesity and fatty liver inhibiting effects and preparation method thereof

A technology of Luo Han Guo extract and Luo Han Guo, applied in the field of biomedicine, can solve problems such as lack of reports, achieve the effects of promoting energy and fat metabolism, safe use, and preventing obesity and fatty liver

Inactive Publication Date: 2019-12-13
GUILIN NATURAL INGREDIENTS CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mogroside V is one of its active ingredients, but there is a lack of relevant reports on its application in obesity and fatty liver

Method used

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  • Grosvenor momordica fruit extract with obesity and fatty liver inhibiting effects and preparation method thereof
  • Grosvenor momordica fruit extract with obesity and fatty liver inhibiting effects and preparation method thereof
  • Grosvenor momordica fruit extract with obesity and fatty liver inhibiting effects and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1, the preparation of Luo Han Guo extract (named Go-Luo, hereinafter replaced with LH)

[0069] 1.1 Preparation steps:

[0070] Take 5000g of fresh Luo Han Guo, rinse it with clean water, put it into a fruit crusher, and add 1.5 times of hot water at 90°C for beating. Then add 50g of compound pectinase (pectinase: cellulase: compound plant hydrolase = 7:2:1, mass ratio), enzymatically hydrolyze at 50°C for 1-2 hours, and add 60g when it is naturally placed at about 40°C Active yeast, and incubated at 40 degrees for 3 hours. The medicinal solution after enzymatic hydrolysis is centrifuged by a centrifuge to remove solid insoluble matter, and then activated carbon (amount of 1% of the mass of the filtrate) is added to the filtrate, and stirred and incubated at 80 degrees for 30 minutes. The medicinal liquid was passed through the plate and frame filter equipment while it was hot, and when the medicinal liquid was cooled to room temperature, it passed through th...

Embodiment 2

[0073] Embodiment 2, Go-Luo (LH) anti-obesity and fatty liver activity test

[0074] 1. Experimental materials

[0075] 1.1 Experimental animals and food:

[0076] NIH male mice (about 20g) were purchased from Guangdong Medical Experimental Animal Center (SPF grade, license number: Yuejian Zhengzi, SCXK (Guangdong) 2013-0002); SPF grade food was purchased from Guangdong Medical Experimental Animal Center; High-fat food (H10141) was purchased from Beijing Huafukang Biotechnology Co., Ltd.

[0077] 1.2 Experimental Drugs

[0078] The Go-Luo (LH) extract was prepared according to the implementation case 1, provided by Guilin Laiyin Biotechnology Co., Ltd.; Orlistat (Orlistat, hereinafter replaced by OL) tablets were purchased from Zhejiang Hisun Pharmaceutical Co., Ltd., The production batch number is 21607031.

[0079] 1.3 Experimental reagents:

[0080]

[0081] Absolute ethanol was purchased from Xilong Science Co., Ltd.; sodium citrate and anhydrous methanol were purc...

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Abstract

The invention discloses a grosvenor momordica fruit extract as well as a preparation method and an application thereof. The preparation method of the grosvenor momordica fruit extract comprises the following steps: 1) cleaning fresh grosvenor momordica fruit, adding water, and pulping to obtain pulp; (2) adding compound pectinase into the pulp to carry out enzymolysis 1; then adding active saccharomycetes to carry out enzymolysis 2; after the enzymolysis 2 is finished, centrifugally collecting a supernate; adding activated carbon into the supernate for adsorption treatment, filtering the material, and collecting a filtrate so as to obtain the grosvenor momordica fruit extract. The extract can be used as a fat metabolism promoter for inhibiting obesity and fatty liver formation. The mechanism of action of the components may involve activation of AMPK, promotion of ECH1 expression, promotion of energy and fat metabolism, and reduction of abdominal fat weight and weight of obese mice, thecomponents can reduce liver injury, so that the enzyme activity of ALT and AST in blood is reduced, and the purpose of protecting the liver is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a monk fruit extract capable of inhibiting obesity and fatty liver and a preparation method thereof. Background technique [0002] Obesity is caused by chronic imbalances in energy intake and metabolism, including overnutrition and lifestyle changes. With the improvement of people's living standards, obesity has become widespread around the world. The obesity rate in developed countries such as the United States has risen sharply after 1980 but has now stabilized, but the obesity rate in developing countries is increasing rapidly. Worldwide, the number of obese people has doubled since 1980, reaching more than 500 million people. Apart from the physical, metabolic and psychological problems caused by obesity itself, the complications caused by obesity itself have become the "invisible killer" of human beings. Complications such as hypertension, diabetes, global ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61P3/04A61P1/16
CPCA61K36/42A61K2236/19A61P1/16A61P3/04
Inventor 谢伟东宋云飞张晓冰丁艺佩廖玲孙鹏博张雅鸥
Owner GUILIN NATURAL INGREDIENTS CORP
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