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Thermosensitive gel preparation of phloretin, and preparation method and application thereof

A gel preparation and temperature-sensitive technology, which is applied in the field of preparation of temperature-sensitive gel preparations, can solve the problems of short action time, poor anti-inflammatory effect of phloretin, and inability to be absorbed by the skin, so as to prevent rapid loss, Simple preparation method, good skin anti-inflammatory effect

Inactive Publication Date: 2019-12-20
WUYI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the drug is administered to the skin, the insoluble drug phloretin in the coating solution will be released and precipitated rapidly, and the action time on the skin surface is short, and the skin cannot absorb it, which eventually leads to poor skin anti-inflammatory effect of phloretin

Method used

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  • Thermosensitive gel preparation of phloretin, and preparation method and application thereof
  • Thermosensitive gel preparation of phloretin, and preparation method and application thereof
  • Thermosensitive gel preparation of phloretin, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A temperature-sensitive gel preparation of phloretin, which is composed of the following components by weight ratio:

[0029]

[0030] The preparation method of the temperature-sensitive gel preparation of phloretin includes the following steps:

[0031] 1) Mix phloretin, polyoxyethylene sorbitan fatty acid ester 80, soybean oil and ethanol in parts to obtain a preliminary solution;

[0032] 2) Add the temperature-sensitive gelling agent xylose agar to the preliminary solution, and adjust the pH of the mixture to 7 after stirring to obtain a gel solution;

[0033] 3) Treat the gel solution with a cell pulverizer at 35 Hz for 35 s, and then homogenize with a high-pressure homogenizer at 1000 Pa for 8 times, each time the homogenization time is 20 s, and the finished product is obtained with an average particle size of 50 nm.

Embodiment 2

[0035] A temperature-sensitive gel preparation of phloretin, which is composed of the following components by weight ratio:

[0036]

[0037] The preparation method of the temperature-sensitive gel preparation of phloretin includes the following steps:

[0038] 1) Mix phloretin, polyethylene glycol 1000, corn oil and chloroform in portions to obtain a preliminary solution;

[0039] 2) Add the temperature-sensitive gelling agent methyl cellulose to the preliminary solution, and adjust the pH value of the mixture to 5 after stirring to obtain a gel solution;

[0040] 3) Treat the gel solution with a cell pulverizer at 35 Hz for 20 s, and then homogenize with a high-pressure homogenizer at 2000 Pa for 5 times, each time the homogenization time is 30 s, and the finished product is obtained with an average particle size of 200 nm.

Embodiment 3

[0042] A temperature-sensitive gel preparation of phloretin, which is composed of the following components by weight ratio:

[0043]

[0044]

[0045] The preparation method of the temperature-sensitive gel preparation of phloretin includes the following steps:

[0046] 1) Mix phloretin, polyvinylpyrrolidone, grape seed oil and acetone in parts to obtain a preliminary solution;

[0047] 2) Add the temperature-sensitive gelling agent polyoxyethylene polyoxypropylene to the preliminary solution, and adjust the pH of the mixture to 8 after stirring to obtain a gel solution;

[0048] 3) Treat the gel solution with a cell pulverizer at 35 Hz for 20 s, and then homogenize it with a high-pressure homogenizer at 1500 Pa for 5 times, each time the homogenization time is 25 s, and the finished product is obtained with an average particle size of 150 nm.

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Abstract

The invention relates to a thermosensitive gel preparation of phloretin as well as a preparation method and application thereof. The thermosensitive gel preparation of the phloretin is prepared from the following raw materials in parts by weight: 10-20 parts of phloretin, 10-30 parts of an oil phase, 10-30 parts of an surfactant, 5-15 parts of a thermosensitive gel, and 5-10 parts of a solvent; and the average particle size of the thermosensitive gel preparation of the phloretin is 50-200nm. The thermosensitive gel preparation of the phloretin disclosed by the invention has appropriate averagegranular particle size, so that suitable gel transition temperature is ensured; and thus, the thermosensitive gel preparation of the phloretin is better matched with skin temperature on the body surface. The thermosensitive gel preparation of the phloretin is flowing liquid at room temperature; however, gel which is not liable to freely flow can be formed when the thermosensitive gel preparationof the phloretin is applied to the skin surface so as to prevent the phloretin from rapid loss on the skin surface, thereby ensuring relatively long acting time of the phloretin on the skin surface soas to improve transdermal absorption of the phloretin. Thus, very good skin anti-inflammatory effects can be achieved.

Description

Technical field [0001] The invention belongs to the field of gel preparations, and specifically relates to a temperature-sensitive gel preparation of phloretin. The invention also relates to a preparation method and application of the temperature-sensitive gel preparation of phloretin. Background technique [0002] Phloretin (Phloretin, Ph), the chemical name is trihydroxyphenol acetone 2,4,6-trihydroxy-3-(4-hydroxyphenyl)propiophenone. Phloretin is a natural flavonoid compound, which is mainly distributed in the peel and root bark of juicy fruits such as apples and pears, as well as a variety of vegetable juices. Because it has the effects of whitening and removing acne, anti-oxidation, and anti-tumor, anti-inflammatory immunity, anti-cardiovascular disease and many other curative effects. As a functional ingredient in preparations or compositions, phloretin has a broad application prospect in the fields of health care products, cosmetics and biomedicine. The structure of phlo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/10A61K47/44A61K47/36A61K47/38A61K31/12A61P17/00A61P29/00A61K8/04A61K8/35A61K8/73A61K8/86A61K8/92A61Q19/00
CPCA61K8/042A61K8/35A61K8/731A61K8/86A61K8/922A61K9/06A61K31/12A61K47/10A61K47/36A61K47/38A61K47/44A61K2800/82A61Q19/00A61P17/00A61P29/00
Inventor 张焜王依翎
Owner WUYI UNIV
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