Capsule type Eletriptan nose inhalation powder aerosols and preparation method and application thereof

Abstract

The invention discloses capsule type Eletriptan nose inhalation powder aerosols. The capsule type Eletriptan nose inhalation powder aerosols consist of Eletriptan micro powder and carrier micro powder. The capsule type Eletriptan nose inhalation powder aerosols are characterized in that the particle sizes of raw material micro powder of the Eletriptan are d10=5-30[mu]m, d50=10-100[mu]m and d90=30-150[mu]m, and the particle size of the carrier micro powder is d90=20-320[mu]m. The invention also provides a preparation method of the capsule type Eletriptan nose inhalation powder aerosols. The preparation method comprises the working procedures of performing Eletriptan micronizing, performing lactose particle preparation, performing mixing and performing subpackaging, wherein during mixing, the micronized Eletriptan and lactose particles are taken, mixing is performed in an equal progressively-increased manner, the mixing speed is 2-15 revolutions per minute, and the mixing time is 5-45 minutes. The capsule type Eletriptan nose inhalation powder aerosols disclosed by the invention comprise 2 kinds of inhalation manners of nose inhalation and oral inhalation, and the Eletriptan can alsoexist in the form of normal saline. The capsule type Eletriptan nose inhalation powder aerosols can reach pain locations in a nose and brain targeting administration manner and can take effect quickly, first-pass effects of the liver are avoided, the biological availability can be improved, the first-pass effects of the liver can be avoided through direct inhalation of the capsule type Eletriptannose inhalation powder aerosols, and consumption and side effects of the medicine are reduced.

Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, and relates to an inhalation powder, in particular to a capsule type eletriptan nasal inhalation powder and its preparation method and application. Background technique

[0002] Migraine (Migraine) is a common chronic neurovascular disease, manifested by recurrent headaches, autonomic dysfunction, and various combinations of other neurological symptoms. Attacks are often accompanied by numerous autonomic nervous system symptoms, such as nausea, vomiting, pale complexion, rapid heart rate, rapid breathing, and gastrointestinal dysfunction. Premonitory manifestations such as numbness, speech difficulties, numbness of one limb or hemiparesis, which lasted for several minutes or half an hour. Most of the onsets are in children and adolescence, and the peak incidence is reached in young and middle-aged adults. It is more common in women, and the ratio of male to female patients is...

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