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Specific detoxification drug for treating paraquat acute poisoning

A paraquat and drug technology, applied in the medical field, can solve the problems of paraquat detoxification, ignoring the inhibitory effect of excessive sodium azide, instability and the like

Pending Publication Date: 2019-12-20
ENVIRONMENT & PLANT PROTECTION INST CHINESE ACADEMY OF TROPICAL AGRI SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, on the one hand, due to the complexity and instability of the ingredients in the preparation, it cannot meet the requirements of drug safety, effectiveness and quality controllability; After quinone, inject paraquat solution into the solution, observe the reaction phenomenon, no solid is formed, and the concentration of paraquat and AHQDS has not decreased after 24h and 48h, indicating that hydroquinone alone is not enough to detoxify paraquat
However, in the "CN201610341330.6" invention, the inventor did not consider the inhibitory effect of excess sodium azide on the reaction between hydroquinone and paraquat

Method used

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  • Specific detoxification drug for treating paraquat acute poisoning
  • Specific detoxification drug for treating paraquat acute poisoning
  • Specific detoxification drug for treating paraquat acute poisoning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] (1) Experimental design 8 treatments: 152 male SD rats (body weight 300±g) were randomly divided into 8 groups, 19 rats in each group.

[0105] Group A: blank control group;

[0106] Group B: Negative control group, treated with antidote drugs only by intragastric administration;

[0107] Group C: poisoned but not detoxified group, treated with paraquat alone;

[0108] Group D: antidote treatment group, 2 hours after intragastric administration of paraquat to the rats, intragastric administration of antidote drugs;

[0109] QD group: antidote treatment group, after 2 hours of intragastric administration of paraquat, the antidote drug treatment was given by intragastric administration for 7 days;

[0110] BID group: antidote treatment group, rats were given paraquat for 2 hours, and treated with antidote drugs, followed by 6 days, 2 times a day;

[0111] TID group: antidote treatment group, rats were given paraquat for 2 hours, then given antidote drug treatment, foll...

Embodiment 2

[0154] (1) Test method: 9 male SD rats (body weight 300±g) were randomly divided into 3 groups, 3 rats in each group.

[0155] Group A: poisoned but not detoxified group, treated with paraquat alone;

[0156] Group B: the antidote treatment group, 6 hours after gavage of paraquat to the rats, the rats were treated with antidote by gavage;

[0157] Group C: routine treatment group, after 6 hours of paraquat gavage, the rats were given "white + black" (refer to the clinical routine treatment plan) treatment.

[0158] Paraquat gavage concentration is 200mg / kg body weight; detoxification drug concentration is 40mmol / L, dosage 6mL; kg body weight, gavage 6mL. If no vomiting occurs, no discharge occurs in the corners of the mouth and nasal cavity of the animal, and no convulsions and death occur immediately, it is considered as successful gavage. Observe the behavioral characteristics and count the survival rate of the rats.

[0159] (2) Test results

[0160] From Table 3 (surv...

Embodiment 3

[0166] (1) Test method: 9 male SD rats (body weight 300±g) were randomly divided into 3 groups, 3 rats in each group.

[0167] Group A: poisoned but not detoxified group, treated with paraquat alone;

[0168] Group B: antidote treatment group, 2 hours after intragastric administration of paraquat, antidote drug treatment;

[0169] Group C: routine treatment group, after 2 hours of paraquat gavage, the rats were given "white + black" (refer to clinical routine treatment plan) treatment.

[0170] Paraquat gavage concentration is 400mg / kg body weight; detoxification drug concentration is 40mmol / L, dosage 6mL; kg body weight, gavage 6mL. If no vomiting occurs, no discharge occurs in the corners of the mouth and nasal cavity of the animal, and no convulsions and death occur immediately, it is considered as successful gavage. Observe the behavioral characteristics and count the survival rate of the rats.

[0171] (2) Test results

[0172] From Table 4 (the survival situation of...

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Abstract

The present invention discloses a specific detoxification drug for treating paraquat acute poisoning. The drug comprises the following main ingredients of a hydroquinone compound or a pharmaceuticallyacceptable salt thereof, preferably 9,10-anthrahydroquinone-2,6-disulfonic acid or 9,10-anthrahydroquinone-2,6-disulfonate (referred to as AHQDS). An application method is as follows: according to dose of paraquat poisoning, different doses of the detoxification drug are mixed, and treatment is conducted by gavage. The drug agent can rapidly reduce concentration of paraquat in blood, urine and lung tissues of rats, significantly reduces toxic reaction of the paraquat in rats, protects lung damages caused by the paraquat, greatly improves a survival rate of the rats suffering from the paraquatacute poisoning, and provides the new drug for clinical treatment of the paraquat poisoning.

Description

technical field [0001] The invention belongs to the field of medical technology, in particular to a specific antidote for treating acute paraquat poisoning. Background technique [0002] Paraquat, as a rapid and non-selective quaternary ammonium herbicide, is widely used in agricultural cultivation because of its strong herbicidal effect and low price. It has made great contributions, and its economic benefits are immeasurable. It is precisely because of its wide application that a variety of self-administration or misuse has caused a large number of poisoning cases, seriously threatening the lives and health of the people in our country. Therefore, from July 1, 2014, the domestic production of paraquat water agent was stopped. In 2016 From July 1, the domestic sales and use of paraquat water solution will be stopped, but the production and sales of paraquat emulsion will still be allowed, and the export market will not be restricted. There are still 10,000 paraquat poison...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K31/095A61K31/192A61K31/136A61K31/055A61P39/02A61D7/00
CPCA61K31/05A61K31/095A61K31/192A61K31/136A61K31/055A61P39/02A61D7/00Y02A50/30
Inventor 武春媛吴东明刘笑然钱进李勤奋
Owner ENVIRONMENT & PLANT PROTECTION INST CHINESE ACADEMY OF TROPICAL AGRI SCI