Carboxymethyl chitosan/sodium alginate nano hydrogel as well as preparation method and application

Abstract

The invention provides carboxymethyl chitosan / sodium alginate nano hydrogel. Carboxymethyl chitosan and sodium alginate form a network interpenetration structural body by ion crosslinking, the networkspace of the network interpenetration structural body can entrap substances. The invention further discloses a preparation method of the nano hydrogel. The preparation method comprises the steps as follows: mixing carboxymethyl chitosan and sodium alginate, and performing ultrasonic treatment to obtain a mixed solution; dropping the mixed solution in ethyl acetate, and performing mechanical stirring and vacuum rotary evaporation to remove an organic phase to obtain an aqueous phase solution; adding a calcium chloride solution to the aqueous phase solution for a crosslinking reaction at room temperature; dialyzing the crosslinked aqueous phase solution, and carrying out freeze-drying to obtain the final product, namely, the carboxymethyl chitosan / sodium alginate nano hydrogel. The constructed nano hydrogel based on carboxymethyl chitosan and sodium alginate shows good protein entrapment capacity, has good biocompatibility and pH sensitivity, and has broad application prospects in oralmedication.

Description

technical field

[0001] The invention belongs to the technical field of biomaterials, in particular to a carboxymethyl chitosan / sodium alginate nano hydrogel. Background technique

[0002] Type 1 diabetes is generally thought to be related to the destruction of insulin-producing pancreatic beta cells, and the immediate need for exogenous insulin is also a hallmark of type 1 diabetes, which requires lifelong treatment. Insulin is still the main drug in the treatment of type 1 diabetes. Due to its nature as a protein drug, invasive parenteral treatment (ie, injection treatment) is still a widely used delivery method. Its effectiveness is limited by the patient's needle phobia, pain, skin swelling, allergic reactions, common infections, and the stress of living on long-term insulin therapy. Also, many patients still suffer from hypoglycemic episodes despite simpler and more effective blood glucose monitoring measures. The incidence of the above adverse reactions varies, and it...

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