A kind of ginseng stem and leaf total saponins vaginal expansion suppository and its preparation method and application
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A technique of vaginal expansive suppository and ginseng stems and leaves, applied in the field of ginseng stems and leaves total saponins vaginal expansive suppository and its preparation, can solve problems such as unfavorable vaginal flora environment, vaginal environment damage, harmful bacteria killing, etc., and achieve good therapeutic effect , Promote full contact and prevent outflow
Active Publication Date: 2021-12-24
HARBIN OT PHARMA +1
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[0006] However, in the prior art, although vaginal medication containing antibiotics such as clotrimazole and metronidazole can have a good antibacterial effect on various fungi, and has curative effect on the treatment of vaginitis, it will affect the vaginal The environment causes harm, it has a killing effect on harmful bacteria, and it also has a killing effect on beneficial bacteria, which is not conducive to maintaining the normal flora environment in the vagina
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Embodiment 1
[0072] This embodiment provides a human stem leaf total saponin vaginal expansion plug, composition as follows:
[0073]
[0074] The preparation method is as follows:
[0075] (1) Crushing the human stem leaf, fried three times, first water fried 2H, the second and third average water fried 1h, combined with three filtrate, filtrate, concentrated into a relative density of 1.10 at 80 ° C Mixing the cleaners and ethanol, eluent 12H, recovered ethanol eluent, concentrates the relative density of 1.35 at 80 ° C, frozen dry, pulverized, gave a hometiosphis leaf total saponin; Spray the upper and lower surfaces of the cotton chip, curl the cotton chip, compress, to obtain a drug-containing expansion inner core;
[0076] (2) Mix the matrix component to melt in a water bath heating pot to obtain a matrix melt;
[0077] (3) Mix safflower and raspberries, conventionally fried, concentrated, freeze dry, pulverized to obtain Chinese medicine composition;
[0078] (4) The matrix melt obtai...
Embodiment 2
[0081] This embodiment provides a human stem leaf total saponin vaginal expansion plug, composition as follows:
[0082]
[0083] The preparation method was the same as in Example 1, and 60 of the vaginal expansion plugs were obtained, and each mass was about 3.5 g.
Embodiment 3
[0085]This embodiment provides a human stem leaf total saponin vaginal expansion plug, composition as follows:
[0086]
[0087] The preparation method was the same as in Example 1, and 130 pieces of vaginal expansion plugs were obtained, and each mass was about 3.6 g.
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Abstract
The present invention provides a ginseng total saponins vaginal expansive suppository and its preparation method and application. The ginseng total saponins vaginal expansive suppository has an inner and outer two-layer structure, the outer layer includes a drug active ingredient and a matrix, and the drug active ingredient Antibiotics, safflower and raspberry; the inner layer consists of a swollen core and total saponins of ginseng stems and leaves covering the swelled core. After the total saponins of ginseng stems and leaves vaginal expansion suppository reaches the lesion site, the active pharmaceutical ingredients of the outer layer are released first, broad-spectrum antibacterial and sterilized, and sedative and anti-inflammatory to the lesion site; The colonization and growth of beneficial bacteria in the vagina are used to rebuild the vaginal micro-ecological balance; the four drug ingredients are released in sequence according to a specific release sequence, and cooperate with each other to kill pathogenic bacteria and rebuild a healthy vaginal micro-ecological environment from the root. The treatment of fungal vaginitis and bacterial vaginosis has high effective rate and low recurrence rate, and realizes the radical cure of vaginitis.
Description
Technical field [0001] The present invention belongs to the field of vaginal suppositories, and involves a human stem leaf of total saponin vaginal expansion plug and its preparation method thereof. Background technique [0002] In recent years, gynecological diseases have high incidence, most women will have varying degrees of vaginal diseases, and women of childbearing ages are a common gynecological disease, mainly showing genital itching and white belt showing white, morbidity Second only to the dripper vaginitis, and the disease will be repeated. The improvement in the vaginal environment of women's women's own health and the future generations of fertility is important. [0003] Antibiotic spectroscopy antibiotics such as gramazole, metronidazole is used to treat vaginitis caused by Candida, which has better antibacterial effect on a variety of fungi. [0004] CN103830198A discloses a gramoxazole vaginal sheet and a preparation method thereof, which is prepared by bilateral...
Claims
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