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Antibacterial and anticoagulant coating, functional material with antibacterial and anticoagulant coating and preparation method of functional material

A functional material and coating technology, applied to medical materials with antibacterial and anticoagulant coatings and their preparation, in the field of antibacterial and anticoagulant coatings, which can solve the problem of non-reactive activity or limited activation methods, and the combination of coatings and substrates Low strength and high risk of coating peeling off, to avoid coating dissociation and peeling, long-lasting anticoagulant and antibacterial effects, and easy operation

Active Publication Date: 2020-01-10
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned patents have effectively improved the internal stability of the coating by constructing a cross-linked network, the coating and the substrate still have problems of low bonding strength, high environmental impact, and a high risk of partial or overall coating shedding.
In the prior art, there is also a method of improving the quaternary ammonium salt. Although the adhesion of the coating is improved, the improved quaternary ammonium salt molecules have potential biological toxicity, high cost, no commercial products, no reactivity or activation Insufficient methods are limited, and it is difficult to handle interventional medical devices with complex structures and non-transparent materials

Method used

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  • Antibacterial and anticoagulant coating, functional material with antibacterial and anticoagulant coating and preparation method of functional material
  • Antibacterial and anticoagulant coating, functional material with antibacterial and anticoagulant coating and preparation method of functional material
  • Antibacterial and anticoagulant coating, functional material with antibacterial and anticoagulant coating and preparation method of functional material

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preparation example Construction

[0102] The present invention also provides a preparation method with an antibacterial and anticoagulant type coating, comprising the following steps:

[0103] 1) after mixing sodium heparin with the organosilicon quaternary ammonium salt solution having the structure of formula (I), obtain organosilicon quaternary ammonium salt / heparin complex solution;

[0104]

[0105] where R 1 and R 2 each independently selected from -CH 3 , -CH 2 CH 3 ;

[0106] R 3 is selected from the alkyl group of C6~C18;

[0107] 2) After thermal curing the organosilicon quaternary ammonium salt / heparin complex solution obtained in the above steps, a coating with antibacterial and anticoagulant type is obtained.

[0108] The present invention compares the structures, materials, specific parameters, specific process parameters, and corresponding optimization principles of the compounds in the above preparation methods with the structures, materials, and specific parameters of the compounds i...

Embodiment 1

[0141] Preparation of antibacterial and anticoagulant medical polyurethane materials

[0142] A) Add 1.0 g of sodium heparin (molecular weight 7500-20000 g / mol) to 5 mL of dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride ethanol solution (0.4 g / mL) , mixed into dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride ethanol / heparin complex solution.

[0143] B) Put the medical polyurethane material into the plasma reaction chamber, pass oxygen at a flow rate of 150cc / min, maintain the working pressure of the reaction chamber at 20Pa, and treat the sample plasma for 15min under 500W power to obtain the surface hydroxylated medical polyurethane material .

[0144] C) The surface hydroxylated polyurethane material obtained in the step B) is obtained in the step A) dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride ethanol / heparin composite It was soaked in the organic silicon quaternary ammonium salt / heparin composite intermediate coating for 5 min...

Embodiment 2

[0147] A) 1.2g of sodium heparin (molecular weight 7500~20000g / mol) was added to 5mL of dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride methanol solution (0.4g / mL) , mixed into dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride ethanol / heparin complex solution.

[0148] B) Put the medical polyurethane material into the plasma reaction chamber, pass oxygen at a flow rate of 200cc / min, maintain the working pressure of the reaction chamber at 30Pa, and treat the sample plasma for 40min under 300W power to obtain the surface hydroxylated medical polyurethane material .

[0149]C) The surface hydroxylated polyurethane material obtained in the step B) is obtained in the step A) dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride ethanol / heparin composite immersed in the compound solution for 3 min to obtain a polyurethane material with a physically loaded organosilicon quaternary ammonium salt / heparin composite intermediate coating.

[0150] D) P...

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Abstract

The invention provides an antibacterial and anticoagulant coating. The antibacterial and anticoagulant coating comprises an organosilicon quaternary ammonium salt heparin compound; the organosilicon quaternary ammonium salt heparin compound is obtained after heparin sodium and organosilicon quaternary ammonium salt react; and the organosilicon quaternary ammonium salt includes a structure shown asa formula (I) (please see the specifications for the formula (I)). Siloxane groups of the organosilicon quaternary ammonium salt in the coating can be in chemical bond connection with heparin sodiummolecules and the surface of a hydroxylated matrix material correspondingly, heparin and the organosilicon quaternary ammonium salt in the coating are mutually crosslinked to form a three-dimensionalnetwork structure, the stability of the coating is improved, meanwhile, the coating and a coated base body are subjected to cross-linking point type chemical bond cross-linking, the stability of the coating and the coated base body is greatly improved, thus dissociation and falling of the coating in the intervening, using and indwelling processes of a medical catheter are avoided, and the anticoagulant and antibacterial effects are more durable. In addition, the coating can be formed only by adopting a heating curing mode, the process is simpler, operation is easy, and feasibility is high.

Description

Technical field [0001] The invention belongs to the field of antibacterial and anticoagulant medical devices, and relates to an antibacterial and anticoagulant coating, a functional material with an antibacterial and anticoagulant coating and a preparation method thereof. In particular, it relates to an antibacterial and anticoagulant coating, an antibacterial and anticoagulant coating, and a preparation method thereof. Medical materials for coagulation type coating and preparation methods thereof. Background technique [0002] Cardiovascular disease, cancer, and diabetes are the three major threats to human health today. High-end interventional medical devices are the main instruments and means for diagnosing and treating various diseases. Global sales are expected to reach 42.5 billion US dollars in 2020, and China will exceed 30 billion yuan. For example, common medical catheters are the core product of interventional medical devices. However, during the intervention, us...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L33/08
CPCA61L29/085A61L29/14A61L33/08A61L2400/18A61L2420/02C08L5/10C08L83/00
Inventor 闫顺杰栾世方孙振龙殷敬华杨华伟班雨周容涛万雪吴刚
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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