Antibacterial and anticoagulant coating, functional material with antibacterial and anticoagulant coating and preparation method of functional material

A functional material and coating technology, applied to medical materials with antibacterial and anticoagulant coatings and their preparation, in the field of antibacterial and anticoagulant coatings, which can solve the problem of non-reactive activity or limited activation methods, and the combination of coatings and substrates Low strength and high risk of coating peeling off, to avoid coating dissociation and peeling, long-lasting anticoagulant and antibacterial effects, and easy operation
CN110665071AActive Publication Date: 2020-01-10CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2020-01-10

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Abstract

The invention provides an antibacterial and anticoagulant coating. The antibacterial and anticoagulant coating comprises an organosilicon quaternary ammonium salt heparin compound; the organosilicon quaternary ammonium salt heparin compound is obtained after heparin sodium and organosilicon quaternary ammonium salt react; and the organosilicon quaternary ammonium salt includes a structure shown asa formula (I) (please see the specifications for the formula (I)). Siloxane groups of the organosilicon quaternary ammonium salt in the coating can be in chemical bond connection with heparin sodiummolecules and the surface of a hydroxylated matrix material correspondingly, heparin and the organosilicon quaternary ammonium salt in the coating are mutually crosslinked to form a three-dimensionalnetwork structure, the stability of the coating is improved, meanwhile, the coating and a coated base body are subjected to cross-linking point type chemical bond cross-linking, the stability of the coating and the coated base body is greatly improved, thus dissociation and falling of the coating in the intervening, using and indwelling processes of a medical catheter are avoided, and the anticoagulant and antibacterial effects are more durable. In addition, the coating can be formed only by adopting a heating curing mode, the process is simpler, operation is easy, and feasibility is high.
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Description

Technical field

[0001] The invention belongs to the field of antibacterial and anticoagulant medical devices, and relates to an antibacterial and anticoagulant coating, a functional material with an antibacterial and anticoagulant coating and a preparation method thereof. In particular, it relates to an antibacterial and anticoagulant coating, an antibacterial and anticoagulant coating, and a preparation method thereof. Medical materials for coagulation type coating and preparation methods thereof. Background technique

[0002] Cardiovascular disease, cancer, and diabetes are the three major threats to human health today. High-end interventional medical devices are the main instruments and means for diagnosing and treating various diseases. Global sales are expected to reach 42.5 billion US dollars in 2020, and China will exceed 30 billion yuan. For example, common medical catheters are the core product of interventional medical devices. However, during the intervention, us...

Claims

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