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Tilmicosin nano-gel breast perfusion agent for livestock and preparation method thereof

A tilmicosin and nanogel technology, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problem of veterinary tilmicosin nanogels that have not yet been seen. Breast infusion preparation methods and other issues, to achieve good transmembrane and intracellular accumulation capacity, quality and safety, and solve the effect of insufficient intake

Inactive Publication Date: 2020-01-17
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there are no reports about the tilmicosin nanogel breast perfusion agent for animals and its preparation method

Method used

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  • Tilmicosin nano-gel breast perfusion agent for livestock and preparation method thereof
  • Tilmicosin nano-gel breast perfusion agent for livestock and preparation method thereof
  • Tilmicosin nano-gel breast perfusion agent for livestock and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1 Prescription 1 of tilmicosin breast perfusion agent for animals

[0074] Veterinary tilmicosin nanogel breast perfusion formulation 1 is shown in Table 1, and the uniformity of the tilmicosin nanogel breast perfusion formulation prepared by prescription 1 is shown in Table 6.

[0075] Table 1 Tilmicosin Nanogel Breast Infusion Prescription 1

[0076]

[0077] Prepare as follows:

[0078] 1) Add 5 g of tilmicosin to 5 mL of castor oil and 5 mL of isopropyl palmitate, heat and stir to dissolve tilmicosin in castor oil and isopropyl palmitate;

[0079] 2) Dissolve 1g of sodium alginate in 90mL of 3.3% Benze 30 aqueous solution and preheat to 100°C, add it to the solution obtained in step 1), and use a 6mm probe to ultrasonically emulsify for 6min to make a nanosuspension of 200-600nm ;

[0080] 3) 1g CaCO 3 and 0.05g sorbic acid are added to step 2) in the nanosuspension of gained, after stirring 5min to disperse, leave standstill 12h, treat that it aut...

Embodiment 2

[0081] Embodiment 2 The prescription 2 of tilmicosin breast perfusion agent for animals

[0082] Veterinary tilmicosin nanogel breast perfusion formulation 2 is shown in Table 2, and the uniformity of the tilmicosin nanogel breast perfusion formulation prepared by prescription 2 is shown in Table 6.

[0083] Table 2 Tilmicosin nanogel breast perfusion formulation 2

[0084]

[0085] Prepare as follows:

[0086] 1) Add 2.05 g of tilmicosin to 10 g of cottonseed oil, heat and stir to dissolve tilmicosin in the cottonseed oil;

[0087] 2) Add 10g of gelatin to 73mL of 2.5% Benzaze 30 and 1.25% polyoxyethylene 400 monolaurate aqueous solution to dissolve and preheat to 100°C, add to the solution obtained in step 1), and emulsify with a 6mm probe for 6 minutes Prepare a nanosuspension of 200-600nm by method;

[0088] 3) Add 1 mL of glutaraldehyde and 0.05 g of methyl p-hydroxybenzoate to the nanosuspension obtained in step 2), stir for 5 minutes to disperse, and let it stand ...

Embodiment 3

[0089] Embodiment 3 Prescription 3 of tilmicosin breast perfusion agent for animals

[0090] Veterinary tilmicosin nanogel breast perfusion formulation 3 is shown in Table 3, and the uniformity of the tilmicosin nanogel breast perfusion formulation prepared by prescription 3 is shown in Table 6.

[0091] Table 3 Tilmicosin nanogel breast infusion formulation 3

[0092]

[0093] Prepare as follows:

[0094] 1) Add 5 g of tilmicosin to 8 g of isopropyl palmitate and 2 g of lanolin, heat and stir to dissolve tilmicosin in isopropyl palmitate and lanolin;

[0095] 2) Dissolve 1g of carbomer and 1g of chitosan in 78mL of 3.75% polyoxyethylene 400 monostearate and 1.25% of Benze 30 aqueous solution and preheat to 100°C, add to the solution obtained in step 1) , using a 6mm probe ultrasonic 6min emulsification method to make a 200-600nm nano-suspension;

[0096] 3) Add 1 g of sodium tripolyphosphate and 0.05 g of sorbic acid into the nanosuspension obtained in step 2), stir for...

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Abstract

The invention belongs to the technical field of veterinary drug preparation, and particularly relates to a tilmicosin nano-gel breast perfusion agent for livestock and a preparation method thereof. The key point is that the invention combines a preparation process of a nano-preparation and a preparation process of a gel drug form and product formulas thereof. The breast perfusion agent comprises the following components in weight / volume (W / V): 0.5-10.0% of tilmicosin, 2.0-20.0% of oil phase, 1.0-5.0% of surface active agents, 0.1-4.0% of gel materials, 0.5-5.0% of crosslinking agents and 0.001-0.05% of preservative, with the balance being water for the preparation. The invention overcomes the defect of front-end release of a pure nano-drug, and can effectively avoid the phenomenon of sudden release of tilmicosin nano-particles. The invention also has the advantages that an emerging gel is good in mucous membrane adhesion and capable of promoting wound healing and maintaining local internal environment, thus obviously improving the treatment effect of the tilmicosin on staphylococcus aureus mastitis. The invention is beneficial to reducing the application amount of the tilmicosin and the breeding cost.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparation, and in particular relates to a tilmicosin nanogel breast perfusion agent for animals and a preparation method thereof. Background technique [0002] Tilmicosin is a semi-synthesized antibiotic for livestock and poultry, which is a hydrolyzate of tylosin. Oral administration and subcutaneous injection absorb quickly, the apparent distribution volume is large, and its tissue penetration is strong, and the drug concentration in lung tissue is more than ten times that of serum. It can quickly and completely enter the mammary gland from the blood, the drug concentration in the milk is high, 10-30 times that of serum, and the maintenance time is long, up to 1-2 days, which is conducive to the exertion of the time-dependent antibiotic tilmicosin. This special pharmacokinetic characteristic is especially suitable for the treatment of infectious diseases such as livestock pneumonia an...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/44A61K47/36A61K31/706A61P31/04A61P15/14
CPCA61K9/0041A61K9/06A61K31/706A61K47/36A61K47/44A61P15/14A61P31/04
Inventor 谢书宇袁宗辉周凯翔陈冬梅潘源虎瞿玮黄玲利陶燕飞程古月郝海红王旭刘振利谢长清
Owner HUAZHONG AGRI UNIV
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