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Angioma gel containing amphiphilic polymers and preparation method of angioma gel

An amphiphilic polymer and hemangioma technology, which is applied in the field of hemangioma gel containing amphiphilic polymers and its preparation, can solve the problems of adverse reactions, high blood drug concentration, unfavorable use of infant patients, etc., and achieve Ease of use, lower blood pressure, and enhanced antiviral ability

Active Publication Date: 2020-02-07
AFFILIATED CHILDRENS HOSPITAL OF CAPITAL INST OF PEDIATRICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patents CN102871956B and CN106727278B respectively disclose propranolol gel and timolol maleate gel for treating hemangioma gel and their preparation methods, but these preparations all contain azone-like transdermal Osmotic agent, will cause blood concentration is too high, and cause systemic adverse reactions, not conducive to the use of infants and young children

Method used

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  • Angioma gel containing amphiphilic polymers and preparation method of angioma gel
  • Angioma gel containing amphiphilic polymers and preparation method of angioma gel
  • Angioma gel containing amphiphilic polymers and preparation method of angioma gel

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Effect test

Embodiment 1

[0028] The preparation of amphiphilic polymer NVP-maleic acid monodocosanol monoester copolymer is carried out according to the following steps:

[0029] (1) Mix maleic anhydride and docosanol at a molar ratio of 1:0.7, stir magnetically at 50°C, react for 4 hours, cool to room temperature, and use methanol and water to mix at a volume ratio of 1:5 100mL, rinse the reaction product, remove excess unreacted maleic anhydride, and dry to obtain behenyl maleate;

[0030] (2) Take 0.005g of the initiator dimethyl azobisisobutyrate, 1g of N-vinylpyrrolidone and 1g of maleic acid monodocosanol monoester obtained in step (1), add 100mL of n-heptane, and Protection, mechanical stirring at 50°C, white precipitate NVP-maleic acid monodocosanol monoester copolymer was obtained.

Embodiment 2

[0032] (1) Mix maleic anhydride and docosanol at a molar ratio of 1.3:1, stir magnetically at 80°C, react for 7 hours, cool to room temperature, and use methanol and water at a volume ratio of 5:9. 260mL, rinse the reaction product, remove excess unreacted maleic anhydride, and dry to obtain behenyl maleate;

[0033](2) Take 0.1g of the initiator dimethyl azobisisobutyrate, 8g of N-vinylpyrrolidone and 4g of behenyl maleate monoester obtained in step (1), add 400mL of n-heptane, and Protection, mechanical stirring at 90°C, white precipitate NVP-maleic acid monodocosanol monoester copolymer was obtained.

Embodiment 3

[0035] (1) Mix maleic anhydride and docosanol at a molar ratio of 1.2:0.9, stir magnetically at 50-80°C, react for 6 hours, cool to room temperature, and mix methanol and water at a volume ratio of 3:7 Mixed solution 150mL, wash reaction product, remove excess unreacted maleic anhydride, dry, obtain behenyl maleate;

[0036] (2) Take 0.06g of the initiator dimethyl azobisisobutyrate, 5g of N-vinylpyrrolidone and 2.5g of behenyl maleate obtained in step (1), add 250mL of n-heptane, and Nitrogen protection, mechanical stirring at 75°C, a white precipitate of NVP-maleic acid monodocosanol monoester copolymer was obtained.

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Abstract

The invention provides an angioma gel containing amphiphilic polymers and a preparation method of the angioma gel and belongs to the technical field of medicine preparations. The angioma gel containing amphiphilic polymers is prepared from propranolol or timolol maleate, NVP-maleic docosanol monoester copolymer, tween-80, lauryl sodium sulfate, propylene glycol, silicone oil, vaseline, acetone chloroform and pure water. The angioma gel has the characteristics of simple preparation, convenience in use, quick response, long acting time, remarkable treatment effect and the like, wherein the NVP-maleic docosanol monoester copolymer can increase the medicine acting time and improve the medicine biocompatibility, has the advantage of sustained release and can reduce use of a transdermal enhancer. The angioma gel is applicable to industrial large-scale production and is used for treating infantile hemangioma.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a hemangioma gel containing an amphiphilic polymer and a preparation method thereof. Background technique [0002] Hemangioma (Infantile Henangiomas, IH) is a congenital benign tumor composed of vascular tissue. It is the most common in infants and young children. The incidence rate is as high as 10% in children under 1 year old, and up to 30% in premature infants. It is proliferative phase, regression phase, and regression completion phase. Generally, the proliferative phase is within 1 year old, and then it will gradually transition to the regression phase. The tumor tissue that regresses is replaced by fat and fibrous tissue, and the skin on the surface of the tumor is loose or scarred. Although 85%-90% of IH can spontaneously regress at the age of 7-10, some severe hemangiomas will persist permanently, even affecting the breathing and vision of infants and...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/34A61K31/138A61K31/5377A61P35/00C08F226/10C08F222/16
CPCA61K9/06A61K47/34A61K31/138A61K31/5377A61P35/00C08F226/10C08F222/16
Inventor 狄奇牛振喜胡靖刘景陈志平
Owner AFFILIATED CHILDRENS HOSPITAL OF CAPITAL INST OF PEDIATRICS
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