A method for determining the content of 6 components in Mango Zhike Tablets by one test and multiple evaluations by hplc method

A mango and content technology, which is applied in the field of HPLC method for the determination of the content of 6 components in Mango Zhike Tablets by one measurement and multiple evaluation, can solve the problems of high detection cost, complex components and high price, and achieves accurate and reliable method, good repeatability and repeatability. Good results
CN110780007BActive Publication Date: 2022-07-08PHARMA FACTORY OF GUANGXI TRADITIONAL CHINESE MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
PHARMA FACTORY OF GUANGXI TRADITIONAL CHINESE MEDICAL UNIV
Publication Date
2022-07-08

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Abstract

The invention discloses an HPLC method for determining the content of 6 components of Mango Zhike Tablets by one measurement and multiple evaluations. The invention adopts the HPLC method, and the chromatographic column is a Phenomenex Gemini C18 column (4.6 mm×250 mm, 5 μm); the mobile phase is acetonitrile ( B)-0.1% phosphoric acid aqueous solution (A); gradient elution; flow rate 1.0mL / min; detection wavelength: 258nm, column temperature 30°C; one-measurement-multiple-evaluation method takes gallic acid as the internal reference, and establishes protocatechuic acid, protocatechuic acid, The relative correction factor (RCF) of mangiferin, homomangiferin, hypericin and isoquercitrin is calculated by RCF, and its measured value is compared and analyzed with the measured result of external standard method. There is no significant difference between the measurement results of the test-multi-assessment method and the external standard method (P>0.05), and the relative correction factors have good repeatability. The high-performance liquid chromatography content determination and one-test-multi-assessment method established in the present invention can be used for Mango Zhike Tablets The content determination of the six components in the method is accurate and reliable, and the repeatability is good, which can be used for the quality control of mango cough tablets.
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Description

technical field

[0001] The invention relates to the technical field of component detection of compound preparations of Chinese patent medicines, in particular to a method for determining the content of 6 components of Mango Zhike Tablets by one measurement and multiple evaluations by HPLC. Background technique

[0002] Mango cough-relieving tablet is a compound preparation of traditional Chinese and Western medicine made of dried mango leaf extract, sodium houttuyniacin, and chlorpheniramine maleate. , asthma, phlegm embolism. Mango cough tablets have been widely used for a long time and have shown good clinical efficacy. The current quality standard is carried out with reference to the National Drug Standard (2014) National Standard No. 0154 issued by the State Food and Drug Administration. This standard has only simple physical and chemical identification methods, and obviously cannot effectively control the quality of the preparation. Although there have been some liter...

Claims

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