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Composite nanoparticles as well as preparation method and application thereof

A composite nanoparticle and nanoparticle technology, applied in the field of tumor radiation therapy sensitizing drugs, can solve the problem that the requirements of photothermal therapy cannot be well met, the preparation and functionalization conditions are harsh, and the morphology of nano gold is prone to change, etc. It can improve the hypoxic microenvironment of tumors, facilitate large-scale industrial production, and achieve the effect of large-scale industrial production.

Inactive Publication Date: 2020-03-06
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Nanogold is used in photothermal therapy due to the adjustable surface plasmon effect on the surface, but the shape of nanogold is easy to change after heating, which affects the stability of photothermal performance, and the price of nanogold is very expensive
Graphene is used in photothermal therapy due to its stable photothermal performance, but due to its low light absorption coefficient, and its preparation and functionalization conditions are relatively harsh.
Organic dyes (indocyanine green, etc.) have good prospects for photothermal applications due to their biodegradable properties, but they are prone to photodegradation after long-term near-infrared light irradiation.
[0006] It can be seen that none of the existing photothermal conversion materials can well meet the requirements of photothermal therapy. Inexpensive, biocompatible composite nanoparticles

Method used

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  • Composite nanoparticles as well as preparation method and application thereof
  • Composite nanoparticles as well as preparation method and application thereof
  • Composite nanoparticles as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A kind of composite nano particle, its preparation method comprises the following steps:

[0043] 1) Disperse 40 μL of tantalum ethanol in 800 μL of absolute ethanol to prepare a tantalum-containing mother solution, and then add the tantalum-containing mother solution dropwise into the ethanol solution (1 mL of absolute ethanol + 10 mL of deionized water) for 2 minutes. Stir at room temperature for 10 minutes, then centrifuge, and wash the centrifuged solid product with deionized water to obtain hollow mesoporous tantalum oxide nanoparticles (HMT);

[0044] 2) Disperse 10 mg of hollow mesoporous tantalum oxide nanoparticles in 10 mL of deionized water, and then add 50 mg of CuCl 2 2H 2 O, stirred at room temperature for 6h, then added 100mg of polyvinylpyrrolidone with a number average molecular weight of 1000g / mol, stirred at room temperature for 1h, then added 50mg of Na 2 S·9H 2 O, heated to 80°C and stirred for 10 minutes, then stopped heating, continued to stir ...

Embodiment 2

[0058] A kind of composite nano particle, its preparation method comprises the following steps:

[0059] 1) Disperse 40 μL of tantalum ethanol in 800 μL of absolute ethanol to prepare a tantalum-containing mother solution, and then add the tantalum-containing mother solution dropwise into the ethanol solution (2 mL of absolute ethanol + 9 mL of deionized water) for 2 minutes. Stir at room temperature for 10 min, then centrifuge, and wash the centrifuged solid product with deionized water to obtain hollow mesoporous tantalum oxide nanoparticles (HMT).

[0060] 2) Disperse 10 mg of hollow mesoporous tantalum oxide nanoparticles in 10 mL of deionized water, and then add 20 mg of CuCl 2 2H 2 O, stirred at room temperature for 6h, then added 100mg of polyvinylpyrrolidone with a number average molecular weight of 40000g / mol, stirred at room temperature for 1h, then added 20mg of Na 2 S·9H 2 O, heated to 80°C and stirred for 10 minutes, then stopped heating, continued to stir for ...

Embodiment 3

[0068] A kind of composite nano particle, its preparation method comprises the following steps:

[0069] 1) Disperse 40 μL of tantalum ethanol in 800 μL of absolute ethanol to prepare a tantalum-containing mother solution, and then add the tantalum-containing mother solution dropwise into the ethanol solution (1 mL of absolute ethanol + 10 mL of deionized water) for 2 minutes. Stir at room temperature for 10 min, then centrifuge, and wash the centrifuged solid product with deionized water to obtain hollow mesoporous tantalum oxide nanoparticles (HMT).

[0070] 2) Disperse 10 mg of hollow mesoporous tantalum oxide nanoparticles in 10 mL of deionized water, and then add 50 mg of CuCl 2 2H 2 O, stirred at room temperature for 6h, then added 100mg of polyvinylpyrrolidone with a number average molecular weight of 40000g / mol, stirred at room temperature for 1h, then added 50mg of Na 2 S·9H 2 O, heated to 60°C and stirred for 10 minutes, then stopped heating, continued to stir for...

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Abstract

The invention discloses composite nanoparticles as well as a preparation method and an application thereof. The composite nanoparticles are composed of hollow mesoporous tantalum oxide nanoparticles,copper sulfide nanocrystals and oxygen-carrying liquid fluorocarbon, the copper sulfide nanocrystals grow on the surfaces of the hollow mesoporous tantalum oxide nanoparticles in situ, and cavities and pore channels of the hollow mesoporous tantalum oxide nanoparticles are filled with the oxygen-carrying liquid fluorocarbon. The preparation method of the composite nanoparticles comprises the following steps: 1) preparing hollow mesoporous tantalum oxide nanoparticles; 2) performing in-situ growth of copper sulfide; 3) performing silanization, 4) performing polyethylene glycol modification; and5) performing liquid fluorocarbon filling and oxygenation. The composite nanoparticles have the advantages of being good in dispersity and biocompatibility, good in tumor radiotherapy sensitization effect, high in photo-thermal conversion efficiency, stable in photo-thermal performance and the like, the synthesis is easy, and the price is low.

Description

technical field [0001] The invention relates to a composite nanoparticle for tumor radiotherapy sensitization, and belongs to the technical field of tumor radiotherapy sensitization drugs. Background technique [0002] At present, the methods commonly used clinically to treat tumors mainly include surgery, chemotherapy, photothermal therapy, photodynamic therapy, immunotherapy, traditional Chinese medicine therapy, and radiation therapy. [0003] Radiation therapy plays a dominant role in the comprehensive treatment of solid malignant tumors. It can kill tumor cells by directly damaging DNA or indirectly generating oxygen free radicals, effectively inhibiting the development of various malignant tumors. However, hypoxia in the solid tumor microenvironment often results in resistance to radiotherapy, reducing radiotherapy-induced tumor cell damage and tumor recurrence. In addition, radiation therapy lacks specificity. While killing tumor cells, it also causes non-selective d...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/02A61K41/00A61P35/00
CPCA61K9/143A61K41/0038A61K41/0052A61P35/00A61K2300/00
Inventor 赵冰夏李颖嘉彭超梁瑜陈思雯钱昕
Owner SOUTHERN MEDICAL UNIVERSITY
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