Application of surface-modified titanium and titanium alloy for dental pulp coronal sealing

A technology of surface modification and titanium alloy, which is applied in the application field of surface modification titanium and titanium alloy, and dental pulp coronal sealing, can solve the problems of prone to cracks or fine channels, increase of pH value, and dentin integration performance to be improved, etc. , to avoid cytotoxicity and promote adhesion

Inactive Publication Date: 2020-04-10
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of current pulp capping materials still has defects: the pH value of MTA and calcium hydroxide rises during the coagulation process, which is strongly alkaline and has cytotoxicity, which will cause cell necrosis and inflammatory reactions in the contacted dental pulp tissue; pulp capping materials The dentin bridge induced by dental pulp stem cells is bone-like dentin, which lacks the structure of physiological dentin tubules, and its physical and mechanical properties are difficult to match with normal dentin. Performance could be improved
At present, there is no report on the use of surface-modified titanium alloys for the coronal sealing of dental pulp

Method used

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  • Application of surface-modified titanium and titanium alloy for dental pulp coronal sealing
  • Application of surface-modified titanium and titanium alloy for dental pulp coronal sealing
  • Application of surface-modified titanium and titanium alloy for dental pulp coronal sealing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of micro-arc oxidation composite graphene oxide coating on titanium sheet.

[0048] Embodiment 1 steps are as follows:

[0049]1. Polish titanium sheets with a size of 20*20*2mm with 320, 800, and 1200 mesh sandpaper in sequence, and place them in ethanol solution and propanol solution for ultrasonic cleaning for 1 hour each.

[0050] 2. Configure an electrolyte solution containing 0.1mol / L calcium acetate monohydrate and 0.03mol / L sodium dihydrogen phosphate, immerse the titanium alloy in the solution, and select the appropriate electrical parameters, namely 400v, 50Hz, 10min.

[0051] 3. Wash the micro-arc oxidized titanium sheet with deionized water, dry it with nitrogen gas, and soak it in 10mol / L NaOH solution at 60°C for 24h. The function of NaOH is to hydroxylate the metal surface so as to chemically react with the next solution to increase hydrophilicity.

[0052] 4. Clean the titanium sheet until the pH is 7. After drying with nitrogen gas, soak ...

Embodiment 2

[0055] Effects of micro-arc oxidation composite graphene oxide on the biological activity of human dental pulp stem cells (hDPSCs) in vitro

[0056] Step 1. Isolation and culture of human dental pulp stem cells

[0057] (1) Collect the clinically extracted teeth due to impaction and orthodontics, and rinse them with sterile PBS solution for 3 times; cut the neck of the teeth with a dental split drill to expose the pulp cavity;

[0058] (2) Pick out the pulp tissue with a sterile pulp extraction needle and place it in a petri dish;

[0059] (3) Use sterile ophthalmic scissors to cut the pulp tissue into pieces about 1*1 mm in size; dip Vaseline on the four corners of the cover slip and cover the cut pulp tissue to prevent the tissue pieces from floating;

[0060] (4) Finally, add MEM culture solution containing 20% ​​fetal bovine serum and 1% double antibody to the culture dish at 37°C and 5% CO 2 Cultivate in the incubator for 7 days and observe. When the cells climb out fro...

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PUM

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Abstract

The invention discloses an application of surface-modified titanium and titanium alloy for dental pulp coronal sealing. The surface modification is used to improve the induction performance of titanium and titanium alloy on adhesion and differentiation of dental pulp cells; and the surface-modified titanium and titanium alloy are used for covering dental pulp tissue after vital pulpotomy or dentalpulp regeneration, so that dental pulp forms a dentin integrated material, wherein the surface-modified titanium and titanium alloy can be selected from micro-arc oxidation composite graphene oxide coating-modified titanium and titanium alloy. The surface-modified titanium or titanium alloy is used as a dental pulp coronal sealing material to promote the adhesion, proliferation, and dentinogenesis differentiation of the dental pulp stem cells to form the physiological dentin structure on the top of the exposed dental pulp.

Description

technical field [0001] The invention relates to the technical field of dental preparations, in particular to the application of surface-modified titanium and titanium alloys for pulp coronal sealing. Background technique [0002] At present, pulpotomy or root canal therapy is mostly used to treat tooth defects caused by dental caries and tooth trauma. Pulpectomy is to remove part of the contaminated pulp tissue and cover the exposed pulp with pulp capping material to prevent or eliminate contamination and control inflammation. The diagnosis and treatment process is cumbersome, requires many visits, and is expensive and technically sensitive. Commonly used pulp capping materials include MTA and calcium hydroxide. The use of current pulp capping materials still has defects: the pH value of MTA and calcium hydroxide rises during the coagulation process, which is strongly alkaline and has cytotoxicity, which will cause cell necrosis and inflammatory reactions in the contacted ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61C5/50A61C19/06C25D11/26C23C26/00
CPCA61C19/06A61C5/50C23C26/00C25D11/026C25D11/26
Inventor 蒋欣泉张文杰孙宁佳殷实
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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