Microneedle patch for losing weight and preparation method thereof

Abstract

The invention relates to a microneedle patch for losing weight and a preparation method thereof. The microneedle patch comprises a micro-needle body and a microneedle substrate, wherein the microneedle body sequentially consists of the following three parts from outside to inside: a microneedle body outer layer made of a soluble polymer material, an emulsifier coating arranged on the inner surfaceof the micro-needle body outer layer, and a microneedle body inner layer formed by an active ingredient mixture; wherein the active ingredient mixture is a mixture formed by dispersing active ingredient lipidosome or active ingredient microspheres in an active ingredient aqueous solution; wherein the soluble polymer material is at least one of hyaluronic acid or sodium salt thereof, povidone, hydroxy propyl cellulose, dextrin and glucan; and the emulsifier coating is prepared from at least one of span, Tween and lecithin. The microneedle patch has high drug loading capacity and good mechanical properties, and has the efficacy of losing weight.

Description

[0001] field of invention [0002] The invention belongs to the field of microneedles, and in particular relates to a microneedle patch for weight loss and a preparation method thereof. Background technique [0003] Obesity is mainly caused by the accumulation of fat in the human body due to excessive intake of calories (fat, sugar) and too little exercise. Obesity will not only affect people's appearance but also bring many diseases. The problem of weight loss has always been concerned by people, and the products for weight loss have great market prospects. In daily beauty treatment, the goal of many dieters is not simply to reduce weight, but more importantly, to reduce body fat ratio. In order to better shape the body, in addition to exercising and controlling diet, dieters also reduce the overall body fat by taking weight-loss drugs. However, the weight loss products for oral administration on the market will have a first-pass effect after use, and the effect of active i...

AI Technical Summary

Problems solved by technology

However, the weight loss products for oral administration on the market will have a first-pass effect after use, and the effect of active ingredients has been discounted after passing through the digestive system, and many dieters are pursuing localized and precise fat loss, while weight loss products for oral administration basically cannot To achieve precise local fat reduction, its effect is to reduce body fat all over the body. Although the body fat has been reduced, there may be situations where the parts you want to shape remain unchanged.

Therefore, it is difficult for the above methods to achieve the desired partial fat reduction on designated parts such as the abdomen, arms and calves, and to make the body fat in other parts of the body normal.

[0004] There are still some weight loss products for external use on the market, but the weight loss products for external use have the following defects: the skin barrier reduces the action efficiency of active ingredients. And cause skin allergies, and some weight loss topical products add ingredients that make people sweat and make people have the illusion of fat loss

However, the high addition of active ingredients generally directly affects the mechanical properties of the soluble microneedles, resulting in low strength and poor toughness of the microneedles, making it impossible for the microneedles to pierce the skin and thus fail to exert the desired effect. Therefore, most of the existing soluble microneedles There is a problem of low drug loading

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