Preparation and application of metal-organic framework nano-pesticides encapsulated by coordination polymers

A technology of metal-organic frameworks and coordination polymers, applied in applications, botany equipment and methods, animal repellents, etc.

Active Publication Date: 2021-09-10
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these nanomaterials are currently concentrated in the field of medicine, and due to the stability of nanomaterials and the complexity of the biological environment, it is difficult to directly apply these nanomaterials to the field of medicine.

Method used

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  • Preparation and application of metal-organic framework nano-pesticides encapsulated by coordination polymers
  • Preparation and application of metal-organic framework nano-pesticides encapsulated by coordination polymers
  • Preparation and application of metal-organic framework nano-pesticides encapsulated by coordination polymers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0041] Example 1-1 A preparation method of a metal-organic framework nano-pesticide encapsulated by a coordination polymer

[0042] Include the following steps:

[0043] (1) 2-aminoterephthalic acid or terephthalic acid (1.24mmol) and FeCl 3 ·6H 2 O (2.48mmol) was dissolved in 25mL of DMF, then glacial acetic acid (18.6mmol) was added, after mixing evenly, it was transferred to a stainless steel reaction kettle and reacted in an oven at 110°C for 24h. After cooling to room temperature, wash with ethanol and DMF three times in sequence, and then reactivate with ethanol for 24 h under reflux, collect the nanoparticles by centrifugation, and dry them in a vacuum oven at 60°C to obtain MIL-101(Fe III ) nanoparticles.

[0044] (2) Take a certain amount of MIL-101 (Fe III ) nanoparticles were dispersed in an ethanol solution containing a certain concentration of tebuconazole (Teb), stirred at room temperature for 24 h, then washed with water and ethanol in turn and centrifuged u...

Embodiment 1-2

[0047] Example 1-2 A preparation method of a metal-organic framework nano-pesticide encapsulated by a coordination polymer

[0048] Include the following steps:

[0049] (1) At room temperature, trimesic acid (0.1mmol) was dissolved in a mixed solvent (200mL ethanol and 100mL DMF) of ethanol and DMF to obtain solution A; Cu(CH 3 COO) 2 ·H 2 O (0.15mmol) was dissolved in a mixed solvent of water and DMF (200mL ethanol and 100mL DMF) to obtain solution B; under high-speed stirring, solution A was quickly added to solution B, and after stirring for 1h, centrifuged to obtain HKUST- 1(Cu II ) nanoparticles.

[0050] (2) Take a certain amount of HKUST-1 (Cu II ) nanoparticles were dispersed in an ethanol solution containing a certain concentration of tebuconazole (Teb), stirred at room temperature for 24 h, then washed with water and ethanol in turn and centrifuged until no tebuconazole signal in the supernatant was detected by HPLC , freeze-dried to obtain Teb@HKUST-1 (Cu II...

experiment example 1

[0054] Experimental example 1 adsorption kinetics measurement:

[0055] Load time to MIL-101(Fe III ) The impact of nanoparticle drug loading: get a certain amount of MIL-101 (Fe III ) nanoparticles were dispersed in an ethanol solution containing tebuconazole, stirred at room temperature, 0.2 mL was sampled at different time points, then washed with ethanol and secondary deionized water and centrifuged until the supernatant could not be detected by HPLC Tebuconazole signal in , and then use a certain volume of 0.5M HCl to decompose Teb@Fe III -After the MIL-101 nanoparticles, the volume was fixed to a certain volume with ethanol, and determined by HPLC.

[0056] Effect of different tebuconazole concentrations on Fe III -Influence of MIL-101 nanoparticle drug loading: a certain amount of MIL-101(Fe III ) nanoparticles were dispersed in ethanol solutions containing different concentrations of tebuconazole, stirred at room temperature for 24h, then washed with ethanol and se...

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Abstract

The invention discloses a preparation method of a metal organic framework nano-pesticide encapsulated by a coordination polymer, using MOF(Fe III ) or MOF (Cu II ) as a pesticide carrier, load pesticide molecules in the solution, and then use tannic acid (tannic acid, TA) or tannic acid-Fe in aqueous solution III (TA‑Fe III ) or tannic acid-Cu II (TA‑Cu II ) Coordination polymers encapsulate pesticide-loaded metal-organic framework nanoparticles. The nanopesticide controlled-release preparation described in the present invention prevents the early release of pesticide molecules in a solvent, increases the lasting efficacy of the pesticide, is environmentally friendly, and achieves the purposes of preventing and controlling pests and increasing agricultural production and quality. The nano-pesticide controlled-release preparation provided by the present invention has a high drug loading rate and good biocompatibility, and the materials used are environmentally friendly, cheap in cost, and simple in the preparation process, and can realize the controlled release performance of pesticides with multiple biological interfaces and environmental responses. Easy to degrade and not easy to accumulate in plants.

Description

technical field [0001] The invention belongs to the field of preparation of nano-pesticide preparations; in particular, it relates to the preparation and application of metal-organic framework nano-pesticides encapsulated by coordination polymers. Background technique [0002] Metal-organic framework (MOF for short) is an organic-inorganic hybrid material with an ordered pore structure formed by the coordination assembly of organic ligands and inorganic metal ions or metal oxygen clusters. In recent years, it has developed very rapidly, and a large number of new metal-organic framework coordination polymers have been synthesized and reported every year, and there are various types. Compared with molecular sieves of pure inorganic materials and porous carbon materials, porous MOF materials have the following important characteristics: 1) MOF is a solid compound with a high degree of crystallinity, which is very conducive to the use of single crystal or polycrystalline diffrac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/10A01N43/653
CPCA01N25/10A01N43/653
Inventor 杜学忠董江涛
Owner NANJING UNIV
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