Carbon nanoparticles for scavenging free radicals as well as preparation method and application thereof

A carbon nanoparticle and free radical technology, applied in the field of free radical scavenging, radiation protection, and nanomaterials, can solve the problems of inability to target the gastrointestinal tract, short drug effect time, large toxic and side effects, etc. Compatibility, long duration of drug effect, fast degradation effect

Active Publication Date: 2020-04-17
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above analysis, the present invention aims to provide a carbon nanoparticle for scavenging free radicals and its preparation method and application to solve the problem that the existing drugs used for radiotherapy protection mainly degrade quickly in vivo, have short drug effect time, and cannot Very good targeting of the gastrointestinal tract, and the problem of large toxic and side effects

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  • Carbon nanoparticles for scavenging free radicals as well as preparation method and application thereof
  • Carbon nanoparticles for scavenging free radicals as well as preparation method and application thereof
  • Carbon nanoparticles for scavenging free radicals as well as preparation method and application thereof

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[0044] A specific embodiment of the present invention discloses a method for preparing carbon nanoparticles used as a free radical scavenger, comprising the following steps:

[0045] Step 1: Add 20-50 milliliters of concentrated nitric acid (mass fraction is 67%) in 40-60 milligrams of carbon raw materials;

[0046] Step 2: reflux at 85-95°C for 5-24 hours;

[0047] Step 3: Cool the mixture down to room temperature, centrifuge at 2000 rpm for 10 minutes, discard the precipitate and keep the supernatant, and remove unreacted carbon raw materials;

[0048] Step 4: The supernatant was centrifuged at 12000 rpm for 10 minutes to obtain a precipitate, which was washed with deionized water until neutral to obtain carbon nanoparticles.

[0049] Further, the carbon raw material includes one or more of carbon black, bamboo charcoal and activated carbon.

[0050] Compared with the prior art, the carbon nanoparticles prepared by the above method have a graphene-like structure, and the c...

Embodiment 1

[0070] (1) Add 20 milliliters of nitric acid (67%) to 40 milligrams of carbon black (from acetylene), and reflux at 85° C. for 24 hours;

[0071] (2) The mixture was cooled down to room temperature, and centrifuged at 2000rpm for 10 minutes;

[0072] (3) Centrifuge the supernatant at 12,000 rpm for 10 minutes, and wash the obtained precipitate with deionized water to pH=6.5;

[0073] (4) Disperse the precipitate in ultrapure water to obtain an aqueous solution of the carbon nanoparticle material, and the concentration of the aqueous solution of the carbon nanoparticle is 1.5 mg / mL;

[0074] (5) Polyethylene glycol succinate is dissolved in ultrapure water to obtain an aqueous solution of polyethylene glycol succinate, and the concentration of the aqueous polyethylene glycol succinate is 1.5 mg / mL;

[0075] (6) Mix 20 milliliters of carbon nanoparticle material aqueous solution with 20 milliliters of polyethylene glycol succinate aqueous solution, centrifuge the mixed solution...

Embodiment 2

[0077] (1) Add 50 milliliters of nitric acid (67%) to 60 milligrams of activated carbon (from acetylene), and reflux at 95° C. for 5 hours;

[0078] (2) The mixture was cooled down to room temperature, and centrifuged at 2000rpm for 10 minutes;

[0079] (3) Centrifuge the supernatant at 12,000 rpm for 10 minutes, and wash the obtained precipitate with deionized water to pH=7.5;

[0080] (4) Disperse the precipitate in ultrapure water to obtain an aqueous solution of the carbon nanoparticle material, and the concentration of the aqueous solution of the carbon nanoparticle is 1.5 mg / mL;

[0081] (5) Dissolving the polylactic acid-glycolic acid copolymer in ultrapure water to obtain a polylactic acid-glycolic acid copolymer aqueous solution, the concentration of the polylactic acid-glycolic acid copolymer aqueous solution is 1.5 mg / mL;

[0082] (6) Mix 20 milliliters of carbon nanoparticle material aqueous solution with 20 milliliters of polylactic acid-glycolic acid copolymer a...

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Abstract

The invention relates to carbon nanoparticles for scavenging free radicals as well as a preparation method and application of the carbon nanoparticles, belongs to the technical field of nano materials, free radical scavenging and radiation protection, and can solve the problems that an existing drug for radiotherapy protection is fast in degradation in vivo, short in drug effect time, incapable ofwell targeting gastrointestinal tracts and large in toxic and side effects. The carbon nanoparticle for scavenging free radicals has a graphene-like structure and contains hydrophilic groups such ascarboxyl and hydroxyl; the hydration particle size of the carbon nanoparticles is 15-25 nm. The preparation method of the carbon nanoparticles comprises the following steps: adding an oxidant into a carbon raw material for oxidation; refluxing for 5 to 24 hours at 85 to 95 DEG C; cooling to room temperature, centrifuging, discarding a precipitate, and reserving a supernatant; and centrifuging thesupernatant, and washing an obtained precipitate product to obtain the carbon nanoparticles. According to the invention, safe and efficient radiotherapy protection on gastrointestinal tracts is realized.

Description

technical field [0001] The invention relates to the technical fields of nanomaterials, free radical scavenging and radiation protection, in particular to a carbon nanoparticle for scavenging free radicals, its preparation method and application. Background technique [0002] Radiation therapy for tumors is one of the most effective methods currently used clinically. Because of its simple treatment methods and less pain for patients, it is widely used clinically. However, in the process of radiotherapy, damage to normal tissues at the tumor site is inevitable. The main culprit of this type of damage is that high-energy rays will radiate water in cells and in the microenvironment to generate a large amount of reactive oxygen species (ROS). ROS free radicals play an important role in the oxidative damage of the body. They can not only destroy Cell membranes, protein structures, they can also interact with macromolecules (such as DNA, RNA) in cells, causing the transfer and dam...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61K47/58A61K47/59A61K47/60A61K47/61A61P39/06
CPCA61K33/44A61K47/58A61K47/593A61K47/60A61K47/61A61P39/06
Inventor 谷战军汪诚艳赵宇亮
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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