Composite leakage-proof reinforcing sheet and preparation method thereof

A reinforcing sheet and composite technology, applied in the field of medical materials, can solve the problems of seldom used in the field of medical and surgical implantation, and achieve the effects of accelerating tissue healing, shortening the process flow, and improving responsiveness and compatibility.

Inactive Publication Date: 2020-04-21
天津百和至远医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its nonwoven products have mature, large-scale and extensive applications in the fields of agriculture, industry, and hygiene, especially as barrier filter adsorption materials, but they are rarely used in the field of medical surgical implants

Method used

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  • Composite leakage-proof reinforcing sheet and preparation method thereof
  • Composite leakage-proof reinforcing sheet and preparation method thereof
  • Composite leakage-proof reinforcing sheet and preparation method thereof

Examples

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Comparison scheme
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preparation example Construction

[0027] The preparation process flow chart of composite leak-proof reinforcing sheet of the present invention is as figure 1 As shown, it specifically includes the following steps:

[0028] 1. Preparation of Chitosan Layer

[0029] A. the preparation of chitosan film: chitosan solution is made in the dissolving acetic acid solution of appropriate amount of chitosan, and acetic acid concentration is 1wt%~5wt%, is preferably 2wt%~4wt%, most preferably is 3wt%; Chitosan The concentration is 1wt%-3wt%, preferably 1.5wt%-2.5wt%, most preferably 2wt%. When the concentration of chitosan is greater than 3wt%, the chitosan is too viscous and the film-forming is uneven; when the concentration of chitosan is less than 1wt%, it is difficult to form and peel off the film and the film-forming strength is too low. Filter the chitosan solution with a No. 2 sand core funnel at a pressure of 0.8-1 MPa. After vacuum defoaming, cast it on a polytetrafluoroethylene plate to form a film, dry it in...

Embodiment 1

[0041] The preparation process of the composite leakage-proof reinforcing sheet of the present embodiment is as follows:

[0042] (1) Get 2g chitosan and dissolve in acetic acid solution to make chitosan aqueous solution, the concentration of acetic acid in the chitosan aqueous solution is 3wt%; The concentration of chitosan is 2wt%. The above-mentioned chitosan solution was filtered with a No. 2 sand core funnel, and the pressure was 1 MPa. After vacuum defoaming, it was cast on a polytetrafluoroethylene plate to form a film, dried in an oven at 50°C, and then peeled off. Then put it into 1mol / L NaOH solution and soak for 24h to neutralize excess acetic acid, take it out, rinse it repeatedly with deionized water until it is neutral, and then dry it naturally for later use. The quality of the chitosan film obtained is 90g / m 2 , the thickness is 0.47mm.

[0043] (2) 3g PLGA chips (PL: PG=75: 25) are thoroughly dried and sent to the screw extruder for heating and melting spinni...

Embodiment 2

[0045] The preparation process of the composite leakage-proof reinforcing sheet of the present embodiment is as follows:

[0046] (1) Get 2g chitosan and dissolve in the acetic acid solution to make chitosan aqueous solution, the concentration of acetic acid in the chitosan aqueous solution is 1wt%, and the concentration of chitosan is 1wt%. The solution is placed in a mold and freeze-dried for 12 hours, then placed in a 1mol / L NaOH solution and soaked for 24 hours to neutralize excess acetic acid, after taking it out, rinse it repeatedly with deionized water until it is neutral and then dry it naturally for later use. The resulting chitosan Sponge quality is 21g / m 2 , with a thickness of 1.0mm.

[0047] (2) 3g PLGA chips (PL: PG=75: 25) are thoroughly dried and sent to the screw extruder for heating and melting spinning. The spinning conditions are as follows: the aspect ratio of the screw extruder is 40, the screw extruder The internal temperature is 270°C, the box tempera...

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Abstract

The invention relates to a composite leakage-proof reinforcing sheet and a preparation method thereof, and belongs to the technical field of medical materials. The composite leakage-proof reinforcingsheet comprises a middle layer, the middle layer is a chitosan film, a chitosan sponge body or a chitosan non-woven fabric, polylactic acid-glycolic acid polymer non-woven fabric layers are formed onthe upper surface and the lower surface of the middle layer through a melt-blowing method, and the middle layer expands to form gel after absorbing body fluid to block gaps so as to avoid liquid diffusion and leakage. According to the reinforcing sheet, the action period of chitosan is prolonged, diffusion and permeation of water molecules in a product can be continuously accelerated, a wet environment is provided for growth of cells in a spatial network of a material, and the problem that the degradation and absorption time is too long due to non-hydrophilicity of PLGA is also solved.

Description

technical field [0001] The invention relates to the technical field of medical materials, more specifically, the invention relates to a composite leak-proof reinforcing sheet and a preparation method thereof. Background technique [0002] In the prior art, there are still many problems in the medical use of anti-leakage and tissue strengthening materials. The use of grafts of animal origin may be at risk of contamination by non-traditional infectious agents, and this risk is further exacerbated by species differences. The fluorine-containing resin material developed later was once the first choice, but there were granulation and skin fistula caused by infection because it could not be degraded. Natural materials such as chitosan or gelatin-based products suffer from insufficient suture reinforcement strength, migration and adhesion. At the same time, this type of material generally lacks the three-dimensional space required for tissue growth, so it is easy to generate pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B32B9/00B32B9/04B32B27/36B32B37/00D04H1/559D04H1/56D04H1/4382D04H1/4374D04H1/4258D04H1/435
CPCB32B5/022B32B9/00B32B9/047B32B37/00B32B2250/20B32B2262/0276B32B2307/716B32B2307/726B32B2307/728B32B2535/00D04H1/4258D04H1/435D04H1/4374D04H1/4382D04H1/559D04H1/56
Inventor 张世超尹俊娇
Owner 天津百和至远医疗技术有限公司
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