Supercharge Your Innovation With Domain-Expert AI Agents!

Microneedle tattoo patches and use thereof

A microneedle and tattoo technology, applied in the direction of microneedle, needle, application, etc., can solve the problem of no tattoo, etc., and achieve the effect of easy application and mass production

Inactive Publication Date: 2020-05-01
MASSACHUSETTS INST OF TECH
View PDF16 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no device that can be used to create tattoos that are invisible under ordinary light

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Microneedle tattoo patches and use thereof
  • Microneedle tattoo patches and use thereof
  • Microneedle tattoo patches and use thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0153] Example 1. Photostability of fluorescent dyes: lanthanide-based inorganic dyes, copper-based quantum dots, and silver-based quantum dots.

[0154] method

[0155] Dye Preparation and Encapsulation in Microparticles

[0156] A lanthanide-based inorganic dye material IRDC3 is obtained. Copper-based quantum dots (copper QDs) were synthesized comprising a core-shell structure in which the core comprises copper indium selenide and the shell comprises a zinc sulfide coating / thin film / capping layer doped with aluminum, denoted as CuInSe2 / ZnS:Al. The quantum yield of the copper-based quantum dots is between 40% and 50%. Copper-based quantum dots were 7,000-fold less toxic in vitro than CdTe QDs and were safely used in mice at a dose of 258 μg / kg (target 3.36 μg / person) (Ding K et al., Biomaterials 2014 ;35:1608-17).

[0157] Synthesis of silver-based quantum dots (silver QDs) comprising a core-shell structure in which the core contains silver indium selenide and the shell...

example 2

[0186] Example 2. Evaluation of the lanthanide-based inorganic dyes IRDC2, IRDC3, IRDC4, IRDC5 and IRDC6.

[0187] Efficiently image in the near-infrared (NIR) range using a custom-made system with a complementary metal-oxide-semiconductor (CMOS) camera. The system consists of a laser source, a beam expander, and a mirror in sequence at a similar level so that the focused laser light is reflected at the mirror to create a spot on the table where the sample is located. The system is compatible with imaging NIR dyes emitting in the 800-1100nm range. Use this system to select the dye with the highest signal-to-noise ratio.

[0188] The lanthanide-based NIR dye IRDC2 has an excitation wavelength below 700 nm and has emission peaks at 880 nm and 1070 nm. The quantum yield of IRDC2 is about 85%. Image 6 It is shown that when IRDC2 is imaged through pigmented human skin at an excitation wavelength of 635nm, different emission wavelengths result in different signal-to-noise (S / N) ...

example 3

[0194] Example 3. Evaluation of the effect of size and sharpness on pain associated with applying and dissolving microneedles in the skin.

[0195] Application of imaging agents to polymer particles incorporated into polymer microneedles increases reproducibility, sensitivity, and ease of manufacture.

[0196] Other advantages of this include low cost, ease of handling (dropped into a bleach bucket), and the ability to deliver larger materials, increasing the contrast to surface adsorption rates.

[0197] Studies were conducted to optimize the microneedle diameter, length, shape and incorporation of particles.

[0198] Materials and methods

[0199] Microneedles composed of 78% polyvinyl alcohol (PVA) and 22% polyvinylpyrrolidone (PVP) were produced using micromolding technology.

[0200] Dye loading is easy by blending and casting into microneedle molds. Tapered (or pencil-shaped) microneedles are mechanically stable.

[0201] Microneedles loaded with 20% IRDC3 were pre...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
lengthaaaaaaaaaa
lengthaaaaaaaaaa
Login to View More

Abstract

Microneedle patches have been developed that can be used to deliver therapeutic, prophylactic, diagnostic agents and / or dyes to the skin. The microneedles encapsulate the agent(s) to be delivered. These are formed of a biodegradable polymer that dissolves upon insertion into skin or tissue, so that the microneedles break off from the substrate forming the patch, remaining in the skin / tissue at thesite of insertion. The patches are used to create a tattoo or to deliver therapeutic, prophylactic or diagnostic agent in combination with a tattoo. In one embodiment, the microneedle patch containsboth vaccine and dye pigments to administer vaccine and record such administration in one application of the microneedle patch.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S.S.N. 62 / 533,081, filed July 16, 2017, which is hereby incorporated by reference in its entirety. [0003] Statement Regarding Federally Funded Research [0004] none. technical field [0005] The present invention generally relates to single-use microneedle tattoo patches that can be used in creating records while delivering medicine, making tattoos invisible to the eye, and in agriculture. Background technique [0006] Tattoos are generally divided into two groups - permanent and temporary. People have tattooed designs and symbols on their skin for thousands of years, usually using sharp objects to damage the skin's surface and then applying dyes, pigments and charcoal to the wounds. These dyes, pigments and charcoal remain in the skin while the wound heals. [0007] In agriculture, permanent tattoos and branding (burn scars) have been used to show ownership. In the U.S....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K39/00A61B90/94A01K11/00A61B5/00
CPCA01K11/005A61B5/6867A61B90/94A61B17/205A61M2037/0053A61M37/0015A61B5/0071A61B90/90A61K9/0021A61M2037/0023A61M2037/0046A61M2037/0061A61B2090/3987A61B2090/395A61M37/0076A61B2090/397A61B50/30A61K49/0069A61K8/0216A61Q1/02A61K49/18A61M2202/30A61B2090/3941A61B2090/3933A61B2090/3979
Inventor A·杰克兰克K·J·麦克休R·S·兰格H·S·N·贾亚沃登S·塞维特京丽红
Owner MASSACHUSETTS INST OF TECH
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com