High-mechanical-strength hydrophilic adsorbent for whole blood perfusion and preparation method of high-mechanical-strength hydrophilic adsorbent
A technology of mechanical strength and hydrophilicity, applied in chemical instruments and methods, inorganic chemistry, suction devices, etc., can solve the problems of insufficient mechanical strength of adsorbent, blood compatibility to be improved, affecting production efficiency and cost, etc. Achieve the effects of improving blood compatibility, improving hydrophilicity and blood compatibility, and improving mechanical strength
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Embodiment 1
[0027] (1) Suspension polymerization is composed of 60g vinylpyridine, 20g styrene, 20g divinylbenzene, 100g acrylonitrile, 100g toluene, and 2g benzoyl peroxide to form an oil phase; mix 400g water and 3g hydroxypropyl methylcellulose Mix the ingredients, stir evenly to obtain the water phase; add the oil phase to the water phase, stir and suspend the reaction at 80°C for 8 hours, remove the porogen in the resin obtained by polymerization, and obtain polymeric microspheres;
[0028] (2) acid-base treatment
[0029] Mix water and hydrochloric acid, stir well, be mixed with hydrochloric acid concentration and be the acid solution of 5wt%; Water and sodium hydroxide are mixed, stir well, be mixed with the lye that the sodium hydroxide concentration is 5wt%; Step (1) obtained The polymeric microspheres were placed in an acid solution and treated with acid at 80°C for 8 hours; after that, the polymeric microspheres were placed in an alkali solution and treated with alkali at 80°C ...
Embodiment 2
[0039] (1) Suspension polymerization consists of 50g styrene, 5g vinylpyridine, 5g methacryloyloxyethyltrimethylammonium chloride, 20g methylstyrene, 20g divinylbenzene, 50g acrylonitrile, 150g toluene, 2g diethyl ammonium chloride AZBN was stirred evenly to form an oil phase; 350g of water and 2g of hydroxyethyl cellulose were mixed, and stirred evenly to obtain a water phase; the oil phase was added to the water phase, stirred and suspended for 10 hours at 70°C, and the The porogen in the polymerized resin is removed to obtain polymeric microspheres;
[0040] (2) acid-base treatment
[0041] Mix water and hydrochloric acid, stir well, be mixed with the acid solution that hydrochloric acid concentration is 2wt%; Mix water and sodium hydroxide, stir well, be mixed with the lye that the sodium hydroxide concentration is 1wt%; Step (1) obtained The polymeric microspheres were placed in the acid solution, and the acid treatment was carried out at 30°C for 24 hours; after that, t...
Embodiment 3
[0051] (1) suspension polymerization is by 20g styrene, 80g ethyl styrene, 20g divinylbenzene, 80g acrylonitrile, 100g toluene, 100g methylcyclohexane, 0.5g benzoyl peroxide stir and form oil phase; Mix water and 10 g of gelatin, stir evenly to obtain a water phase; add the oil phase to the water phase, stir and suspend at 78°C for 5 hours, remove the porogen in the polymerized resin, and obtain polymeric microspheres;
[0052] (2) acid-base treatment
[0053] Mix water and phosphoric acid, stir evenly, be mixed with phosphoric acid concentration and be the acid solution of 10wt%; Water and potassium hydroxide are mixed, stir well, be mixed with the alkali liquor that potassium hydroxide concentration is 2wt%; Step (1) obtained The polymeric microspheres were placed in an acid solution and treated with acid at 40°C for 10 hours; after that, the polymeric microspheres were placed in an alkaline solution and treated with alkali at 50°C for 12 hours; purified to obtain high mecha...
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Abstract
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