Preparing method of antibacterial three-dimensional porous bone implantation material

A bone implant material and three-dimensional porous technology, applied in electrolytic coatings, pharmaceutical formulations, surface reaction electrolytic coatings, etc., can solve the problems of poor antibacterial performance, improve arc starting ability, antibacterial and antibacterial performance and biological activity , Improve the effect of distribution uniformity and stability

Pending Publication Date: 2020-06-02
BEIJING AKEC MEDICAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The main purpose of the present invention is to provide a method for preparing an antibacterial three-dimensional porous bone i...

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  • Preparing method of antibacterial three-dimensional porous bone implantation material
  • Preparing method of antibacterial three-dimensional porous bone implantation material
  • Preparing method of antibacterial three-dimensional porous bone implantation material

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preparation example Construction

[0025]In a typical implementation of the present application, a method for preparing an antibacterial three-dimensional porous bone implant material is provided, the preparation method comprising: performing surface activation treatment on the three-dimensional porous bone implant material to obtain a pretreated material; The treated material is subjected to micro-arc oxidation treatment to form an in-situ growth film layer with antibacterial ions on the surface of the pretreated material, wherein the electrolyte used in the micro-arc oxidation treatment includes antibacterial ions and functional substances, and the antibacterial ions are selected from zinc ions, copper ions, and Any one or more of ions and silver ions; and hydrothermal treatment is performed on the film layer grown in situ to obtain an antibacterial three-dimensional porous bone implant material.

[0026] This application performs surface activation treatment on the three-dimensional porous bone implant materi...

Embodiment 1

[0042] The artificial vertebral body of Ti-6Al-4V is antibacterially treated. The height of the artificial vertebral body is 50mm, the diameter of the inscribed circle of the structural hole of the artificial vertebral body is 5mm, the diameter of the circumscribed circle of the artificial The included angle is 5°, the porosity is 60%, and the average pore diameter is 800 μm.

[0043] Pickling the artificial vertebral body, the volume ratio of the pickling solution is hydrofluoric acid with a concentration of 40%: nitric acid with a concentration of 68%: deionized water = 6:12:82, use the pickling solution to acidify the titanium material After washing for 15 minutes, use deionized water to ultrasonically clean for 10 minutes, then spray, rinse and dry to obtain the pretreated material;

[0044] The pretreated material is used as the anode, and the stainless steel is used as the cathode. The porous material is placed in the electrolyte for micro-arc oxidation, and an in-situ g...

Embodiment 2

[0049] The difference from Example 1 is:

[0050] The concentration of zinc acetate in the electrolyte is 35g / L, and the micro-arc oxidation treatment process conditions are: oxidation voltage 600V, output pulse frequency of power supply 1000Hz, peak current setting 500A, oxidation time 20min. The electrolyte temperature is controlled at about 10°C during the oxidation process.

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Abstract

The invention provides a preparing method of an antibacterial three-dimensional porous bone implantation material. The preparing method includes the steps of performing surface activating treatment onthe three-dimensional porous bone implantation material to obtain a preprocessed material; performing micro-arc oxidation treatment on the preprocessed material to obtain an in-situ growing film layer formed on the surface of the preprocessed material and provided with antibacterial ions, wherein electrolyte adopted for micro-arc oxidation treatment includes antibacterial ions and functional substances, and the antibacterial ions are any one of or more of zinc ions, copper ions and silver ions; and performing hydrothermal treatment on the in-situ growing film layer to obtain the antibacterialthree-dimensional porous bone implantation material. The antibacterial three-dimensional porous bone implantation material obtained through the preparing method has an antibacterial effect. The macroaperture and micro aperture of the antibacterial three-dimensional porous bone implantation material coexist, micro pores in a micro-arc oxidation film layer on a porous wall can provide anchoring points for bone ingrowth, meanwhile the specific surface area of the implantation material is effectively increased, and the implantation material has an antibacterial function and biological functionsof bone ingrowth and bone induction.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a method for preparing an antibacterial three-dimensional porous bone implant material. Background technique [0002] With the improvement of medical technology and the development of economic level, various implants such as titanium and titanium alloys used for orthopedic replacement, orthopedics, and fixation are more and more used in surgery. In recent years, porous bone implant materials , such as 3D printing titanium alloy and porous tantalum metal, have also been commercially applied clinically as bone implant materials, achieving the purpose of solving patients' pain and restoring function. Putting implant material in the human body is an invasive procedure, and postoperative complications are also prone to occur, especially the related infection caused by the implant becomes the most serious and even catastrophic complication of its use, especially in open fractures , It i...

Claims

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Application Information

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IPC IPC(8): C25D11/26C25D11/02A61L27/06A61L27/30A61L27/56A61L27/58
CPCA61L27/06A61L27/306A61L27/56A61L27/58A61L2400/18A61L2420/02A61L2430/02A61L2430/38C25D11/024C25D11/026C25D11/26
Inventor 魏崇斌
Owner BEIJING AKEC MEDICAL
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