Method for synthesizing N-isopropylbenzylamine
A technology of isopropylbenzylamine and isopropylamine, which is applied in the field of synthesis of N-isopropylbenzylamine, can solve the problems of many wastes, high cost, and high requirements for production equipment, and achieve good reaction selectivity, few by-products, The effect of high yield
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Embodiment 1
[0020] (1) Ammonolysis reaction: put 71g of isopropylamine, 0.6g of copper oxide, and 120g of methanol into a 250ml reaction bottle, add 60g of benzyl chloride while stirring, react at 30°C until the reaction of the raw material benzyl chloride is complete, and cool the reaction solution to 0°C , filtered to remove the catalyst and the organic salts produced, and recovered methanol under reduced pressure to obtain the crude product of N-isopropylbenzylamine. , GC>99%.
Embodiment 2
[0022] (1) Ammonolysis reaction: drop 85g of isopropylamine, 1.2g of cuprous chloride, and 100g of ethanol into a 250ml reaction bottle, add 60g of benzyl chloride during stirring, react at 40°C until the reaction of the raw material benzyl chloride is complete, and cool the reaction solution to 0°C, remove the catalyst and the organic salt produced by filtration, recover ethanol under reduced pressure, and obtain the crude product of N-isopropylbenzylamine. %), GC>99%.
example 3
[0024] (1) Ammonolysis reaction: put 75g of isopropylamine, 6.0g of cuprous iodide, and 90g of ethyl acetate into a 250ml reaction bottle, add 60g of benzyl chloride while stirring, and react at 60°C until the reaction of the raw material benzyl chloride is complete. Cool down to 1°C, remove the catalyst and the generated organic salt by filtration, recover ethyl acetate under reduced pressure to obtain crude N-isopropylbenzylamine, and obtain 58.7g of pure N-isopropylbenzylamine after the crude product is rectified under reduced pressure (Yield 83.2%), GC>99%.
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