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Polylactic acid/nano-hydroxyapatite composite material as well as preparation method and application thereof

A nano-hydroxyapatite and composite material technology, applied in the field of biomedicine, can solve the problems of decreased mechanical properties of products, easy thermal degradation of polylactic acid, low impact strength, etc., to improve mechanical properties, avoid low impact strength, Reduce the effect of thermal degradation

Active Publication Date: 2020-06-16
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the present invention aims to propose a preparation method of polylactic acid / nano-hydroxyapatite composite material, to solve the problem of nano-hydroxyapatite in the polylactic acid matrix in the preparation of existing polylactic acid / nano-hydroxyapatite composite material. It is easy to agglomerate, and polylactic acid is easy to thermally degrade, resulting in the decline of mechanical properties and low impact strength of the product.

Method used

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  • Polylactic acid/nano-hydroxyapatite composite material as well as preparation method and application thereof
  • Polylactic acid/nano-hydroxyapatite composite material as well as preparation method and application thereof
  • Polylactic acid/nano-hydroxyapatite composite material as well as preparation method and application thereof

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Embodiment 1

[0032] A preparation method of polylactic acid / nano hydroxyapatite composite material, specifically comprising the following steps:

[0033] 1) Precipitation method is used to prepare nano-hydroxyapatite at 37°C: prepare an aqueous solution of calcium chloride with a concentration of 0.0668mol / L and an aqueous solution of diammonium hydrogen phosphate with a concentration of 0.04mol / L, and follow the Ca / P molar ratio of 1.67 After mixing the calcium chloride aqueous solution and the diammonium hydrogen phosphate aqueous solution, the pH value of the mixed solution is controlled at 9-10 with a sodium hydroxide aqueous solution with a concentration of 1mol / L, and then heated in a constant temperature water bath at 37°C Stir for 3 hours, then stand still for 24 hours, filter with suction, wash with deionized water, and freeze-dry to obtain white powdery nano-hydroxyapatite with a particle size of 50nm-80nm for subsequent use;

[0034] 2) Polylactic acid / nano-hydroxyapatite compos...

Embodiment 2

[0041] A preparation method of polylactic acid / nano hydroxyapatite composite material, specifically comprising the following steps:

[0042] 1) Precipitation method is used to prepare nano-hydroxyapatite at 37°C: prepare an aqueous solution of calcium chloride with a concentration of 0.0668mol / L and an aqueous solution of diammonium hydrogen phosphate with a concentration of 0.04mol / L, and follow the Ca / P molar ratio of 1.67 After mixing the calcium chloride aqueous solution and the diammonium hydrogen phosphate aqueous solution, the pH value of the mixed solution is controlled at 9-10 with a sodium hydroxide aqueous solution with a concentration of 1mol / L, and then heated in a constant temperature water bath at 37°C Stir for 3 hours, then stand still for 24 hours, filter with suction, wash with deionized water, and freeze-dry to obtain white powdery nano-hydroxyapatite with a particle size of 50nm-80nm for subsequent use;

[0043] 2) Polylactic acid / nano-hydroxyapatite compos...

Embodiment 3

[0050] A preparation method of polylactic acid / nano hydroxyapatite composite material, specifically comprising the following steps:

[0051] 1) Precipitation method is used to prepare nano-hydroxyapatite at 37°C: prepare an aqueous solution of calcium chloride with a concentration of 0.0668mol / L and an aqueous solution of diammonium hydrogen phosphate with a concentration of 0.04mol / L, and follow the Ca / P molar ratio of 1.67 After mixing the calcium chloride aqueous solution and the diammonium hydrogen phosphate aqueous solution, the pH value of the mixed solution is controlled at 9-10 with a sodium hydroxide aqueous solution with a concentration of 1mol / L, and then heated in a constant temperature water bath at 37°C Stir for 3 hours, then stand still for 24 hours, filter with suction, wash with deionized water, and freeze-dry to obtain white powdery nano-hydroxyapatite with a particle size of 50nm-80nm for subsequent use;

[0052] 2) Polylactic acid / nano-hydroxyapatite compos...

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Abstract

The invention provides a polylactic acid / nano-hydroxyapatite composite material as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly,preparing polylactic acid / nano-hydroxyapatite composite microspheres as a powder raw material by adopting an emulsion solvent evaporation method, then putting the powder raw material into a mold, heating, pressurizing and molding the powder raw material to obtain the polylactic acid / nano-hydroxyapatite composite material. By adopting the preparation method disclosed by the invention, uniform dispersion of the nano-hydroxyapatite in a polylactic acid matrix is facilitated, so that the mechanical property and the impact strength of the product are improved, the microstructure of the molded product is easy to control, and a microsphere bonded porous structure and a microsphere fused compact structure can be obtained by adjusting the temperature and the pressure or adding a pore-forming agent.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a polylactic acid / nano hydroxyapatite composite material and a preparation method and application thereof. Background technique [0002] Polylactic acid (polylactic acid) is a polymer material with good biocompatibility and biodegradability. It has the characteristics of non-toxicity and good thermoformability, and its degradation products can participate in human metabolism. In the field of tissue engineering Medium can meet the requirements as a cell growth carrier material, and is widely used in the field of clinical tissue repair. However, polylactic acid has poor hydrophilicity, and the acidic degradation products can easily cause aseptic inflammation, which is not conducive to cell adhesion and growth. Hydroxyapatite is the main inorganic component of human bones. It has good biocompatibility and bioactivity, good cell affinity, and can form a firm osseointegration wit...

Claims

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Application Information

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IPC IPC(8): C08J9/26C08J3/12C08L67/04C08L29/04C08K3/32A61L27/46A61L27/50A61L27/56B29C43/02
CPCA61L27/46A61L27/50A61L27/56A61L2400/12B29C43/02C08J3/12C08J9/26C08J2201/0422C08J2201/0446C08J2329/04C08J2367/04C08J2429/04C08J2467/04C08K2003/325C08K2201/003C08K2201/011C08L67/04
Inventor 韩颖超谢燕萍胡洪钞
Owner WUHAN UNIV OF TECH
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