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Surface anticoagulation modification method of hemodialyzer and application of hemodialyzer

A technology of hemodialysis and modification methods, which is applied in dialysis systems, suction devices, and drug devices, etc., can solve the problems of long time consumption and high energy consumption, and achieve the effects of good load, simple process flow, and good anticoagulation effect.

Active Publication Date: 2020-06-26
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In CN109675134A, the inventor of this case adopted a process technology combining adsorption and hydrothermal crosslinking. Although the modified dialyzer finally prepared has a very stable artificial heparin load on the surface, the entire process flow needs to be modified. The dialyzer performs multiple processes such as liquid filling, hydrothermal crosslinking, and flushing, especially the hydrothermal crosslinking process consumes a lot of energy and takes a long time

Method used

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  • Surface anticoagulation modification method of hemodialyzer and application of hemodialyzer
  • Surface anticoagulation modification method of hemodialyzer and application of hemodialyzer

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preparation example Construction

[0044] Wherein, as a more preferred embodiment of the present invention, the synthesis method of the amphiphilic anticoagulant copolymer comprises the following steps:

[0045] Step (1). Add a certain amount of unsaturated double bond sulfonic acid sodium salt monomer, acrylic acid monomer and long carbon chain olefin ester monomer in the first organic solvent of 100 milliliters, stir through nitrogen or argon atmosphere without stirring. Less than 30min to get rid of the oxygen in the reaction solution;

[0046] Step (2). Add a certain amount of initiator, keep stirring in a nitrogen or argon atmosphere, and raise the temperature to 50-100°C, and react for 8-24 hours;

[0047] Step (3). Transfer the solution to an environment of 20-50° C., dry to remove the first organic solvent, and obtain the amphiphilic anticoagulant copolymer.

[0048] In some preferred embodiments, the surface anticoagulation modification method specifically includes: dissolving the amphiphilic anticoag...

Embodiment 1

[0069] Step (1) 6 grams of sodium p-styrene sulfonate, 2 grams of acrylic acid and 8 grams of myristyl methacrylate added in 100 milliliters of ethanol were stirred for 30 minutes at a speed of 600 r / min to eliminate Oxygen in the reaction solution;

[0070] Step (2) Add 0.3 g of dimethyl azobisisocarboxylate, keep stirring in a nitrogen atmosphere, and raise the temperature to 80° C., and react for 16 hours;

[0071] Step (3) transfer the solution to an environment of 50° C., dry and remove ethanol to obtain an amphiphilic anticoagulant copolymer;

[0072] Step (4) configuration volume ratio is 100ml of N, N-dimethylacetamide aqueous solution 100ml, adds the polyoxyethylene-polyoxypropylene copolymer of 0.3 gram, and adds the amphiphilic anticoagulant copolymer of 3 gram synthesis , to obtain a modified solution.

[0073] Step (5) At normal temperature, the modified solution is transported into the dialyzer at a speed of 100 ml / square meter per minute, so that it flows thro...

Embodiment 2

[0079] Step (1) 5 grams of sodium methacrylate, 3 grams of methacrylic acid and 6 grams of octadecyl methacrylate added in 100 milliliters of n-hexane, through an argon atmosphere, at a speed of 400r / min Stir for 40min to get rid of the oxygen in the reaction solution;

[0080] Step (2) Add 0.2 g of azobisisobutyronitrile, keep stirring in an argon atmosphere, and raise the temperature to 50° C., and react for 24 hours;

[0081] Step (3) transfer the solution to an environment of 20°C, dry and remove n-hexane to obtain an amphiphilic anticoagulant copolymer;

[0082] Step (4) Prepare 100 ml of triethyl phosphate aqueous solution with a volume ratio of 15%, add 0.5 g of Span 80, and add 4 g of synthesized amphiphilic anticoagulant copolymer to obtain a modified solution.

[0083] Step (5) At room temperature, the modified solution is transported into the dialyzer at a speed of 200 ml / square meter per minute, so that it flows through the inner surface of the dialyzer membrane f...

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Abstract

The invention discloses a surface anticoagulation modification method of a hemodialyzer and an application of a hemodialyzer. The surface anticoagulation modification method includes the following steps: in a protective atmosphere, performing a reaction on a uniform mixing reaction system of a sodium sulfonate salt monomer containing an unsaturated double bond, an acrylic acid monomer, a long carbon chain olefin ester monomer, an initiator, and a first organic solvent at 50-100 DEG C for 8-24 h to obtain an amphiphilic anticoagulant copolymer; mixing the amphiphilic anticoagulation copolymer and a mixed solvent to form a modified solution, wherein the mixed solvent includes a second organic solvent, water and an interfacial melting agent; and allowing the membrane filament inner surface ofthe hemodialyzer to be in contact with the modified solution to obtain the hemodialyzer with high anticoagulant performance. The method can realize the rapid adsorption of heparin-like anticoagulantmolecules on the membrane filament surface of the hemodialyzer, a sufficient degree of adsorption force can be provided to ensure that the heparin-like molecules do not fall off in the dialysis process, and a good anticoagulant effect can be realized; and the method is simple in process, and convenient for industrial production and promotion.

Description

technical field [0001] The invention belongs to the field of blood purification, and in particular relates to a surface anticoagulant modification method of a hemodialyzer and its application in blood purification. Background technique [0002] Uremia is a disease in which the patient has renal insufficiency, and the accumulation of metabolites leads to endocrine dysfunction and a series of symptoms of poisoning. Nitrogen-containing metabolites and other toxic substances in patients cannot be excreted normally and accumulate in the body, causing lesions in the body's organs and systems, and causing a series of complications that endanger life safety. At present, compared with the difficulty in finding suitable kidney sources in kidney transplantation, hemodialysis has developed into the key to maintaining the lives of patients with kidney disease. A key component of hemodialysis is the hemodialysis membrane. At present, most mature hemodialysis membranes use polymer-based ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/16A61L31/14A61L31/00C08F220/18C08F212/14C08F220/06C08F228/02A61M1/16
CPCA61L31/10A61L31/16A61L31/14A61L31/00C08F220/18A61M1/1621A61L2300/216A61L2300/42A61M2202/0413C08L33/064A61M2202/0021
Inventor 刘富林海波柳杨韩秋
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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