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Ultrasonic synthesis method and application of different single-metal and double-metal two-dimensional MOFs nano-enzymes

An ultrasonic synthesis, bimetallic technology, applied in the fields of nanomaterials, catalysis and analytical chemistry, can solve the problems of low specific surface area, high pressure risk, long reaction period, etc., and achieve complex process, mild conditions and uniform morphology. Effect

Inactive Publication Date: 2020-06-26
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the synthesis method of MOFs nanozymes is mostly hydrothermal method, and although the synthesis steps of hydrothermal method are simple, there are some disadvantages to a certain extent, such as high pressure risk, long reaction cycle, and even the need to use toxic solvents, and the synthesis The material volume is large, the specific surface area is not high, and the thermal stability and chemical stability are poor, which is not conducive to practical application.
However, there is no report on the synthesis of two-dimensional structure MOFs nanozyme materials with various enzyme-like catalytic activities by ultrasonic method. In addition, there is no research report on two-dimensional MOFs nanozyme materials with enzyme-like catalytic activities in organic solvents.

Method used

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  • Ultrasonic synthesis method and application of different single-metal and double-metal two-dimensional MOFs nano-enzymes
  • Ultrasonic synthesis method and application of different single-metal and double-metal two-dimensional MOFs nano-enzymes
  • Ultrasonic synthesis method and application of different single-metal and double-metal two-dimensional MOFs nano-enzymes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Synthesis of different monometallic and bimetallic two-dimensional MOFs nanozyme materials:

[0043] (1) Ultrasonically dissolve 0.75 mmol of terephthalic acid in a solvent composed of DMF, secondary water and ethanol at a volume ratio of 16:1:1 to obtain a colorless and clear solution, and then add 0.375 mmol of any two different metal salts in the above clarified solution;

[0044] (2) Quickly inject 0.8 mL of triethylamine into the solution of metal salt in (1), and stir at room temperature for 5 min to obtain a colloidal suspension mixed solution;

[0045] (3) Pack the colloidal suspension mixed solution into a polytetrafluoroethylene tube, seal the nozzle, and conduct ultrasonic reaction at 25°C and ultrasonic power 80KHz for 3h, then centrifuge at 5000r / min with ethanol for 3min, every Washed three times, and finally dried under vacuum at 60°C to obtain different bimetallic two-dimensional MOFs nanozyme materials.

[0046] Control experiment: only any metal salt...

Embodiment 2

[0050] Morphological analysis of different monometallic and bimetallic two-dimensional MOFs nanozyme materials:

[0051] The suspensions of different monometallic and bimetallic two-dimensional MOFs nanozyme materials were dropped on copper grids, dried at room temperature, and analyzed by transmission electron microscopy.

[0052] like figure 2 As shown, the morphology of the obtained bimetallic NiCo-MOF nanozyme material is a regular two-dimensional sheet structure, indicating that the MOFs synthesized by ultrasonic method have a two-dimensional structure. Meanwhile, the as-synthesized monometallic Co-MOF and Ni-MOF nanomaterials are two-dimensional sheet structures, but their morphology is not as regular as that of bimetallic NiCo-MOF nanozyme materials. In summary, the morphologies of different monometallic and bimetallic MOFs prepared by ultrasonic synthesis are two-dimensional structures.

Embodiment 3

[0054] The imitation enzyme activity of different monometallic and bimetallic two-dimensional MOFs nanoenzyme materials:

[0055] A: Mimic peroxidase activity of different monometallic and bimetallic two-dimensional MOFs nanoenzyme materials:

[0056] Experimental system a: The catalytic reaction system contains 1mmol / L H 2 o 2 , 2 μg / mL of different monometallic or bimetallic two-dimensional MOFs nanoenzyme materials obtained in Example 1 above, 0.5mmol / L organic chromogenic agent TMB and 0.1mol / L acetate buffer solution with pH 4. After reacting at room temperature of 25°C for 30min, centrifuge at 8000r / min for 3min, take the supernatant, and record its spectrum in the wavelength range of 300-800nm ​​with an ultraviolet-visible spectrophotometer.

[0057] Control experiment b: when there is no monometallic or bimetallic two-dimensional MOFs nanoenzyme material in the catalytic reaction system, and the remaining conditions are the same as the above experimental system, afte...

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Abstract

The invention discloses an ultrasonic synthesis method of different single-metal and double-metal two-dimensional MOFs nano-enzymes and application of the nano-enzymes. The invention relates to the technical field of nanometer materials, catalysis and analytical chemistry. The ultrasonic synthesis method is simple, low in cost and mild in condition, the synthesized different single-metal and double-metal two-dimensional MOFs nano-enzyme materials are high in yield, uniform in morphology, good in performance and free of surfactants, and the defects that a traditional hydrothermal method is complex in process, large in energy consumption, difficult in MOFs volume and morphology control and the like are overcome. The different single-metal and double-metal two-dimensional MOFs nano-enzymes synthesized by the method disclosed by the invention have various biomimetic catalysis characteristics, such as peroxidase-like activity, chloroperoxidase-like activity, glucose oxidase-like activity, laccase-like activity and NADH enzyme-like activity, show unique oxidative activity of peroxidase and chloroperoxidase in an organic solvent, and can be used for indole oxidation.

Description

technical field [0001] The invention relates to the technical fields of nanomaterials, catalysis and analytical chemistry, in particular to an ultrasonic synthesis method of different monometallic and bimetallic two-dimensional MOFs nanozymes and its application. Background technique [0002] As we all know, metal organic frameworks (Metal Organic Frameworks, MOFs) are a three-dimensional porous periodic network formed by transition metal ions or metal clusters and organic ligands containing oxygen, nitrogen and other atoms through molecular self-assembly. Topologically structured crystalline materials. MOFs have the characteristics of adjustable structural components, ordered pores, high specific surface area, abundant metal active sites, good thermal stability, and adjustable pore size. In recent years, they have been widely used in storage, separation, drug delivery and catalysis. field, it has received more and more attention from researchers. [0003] With the rapid d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J31/22B01J37/34
CPCB01J31/003B01J31/1691B01J31/223B01J37/343B01J2531/16B01J2531/72B01J2531/842B01J2531/845B01J2531/847
Inventor 韩磊陈道缘
Owner QINGDAO AGRI UNIV
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