A thermogenic hydrogel metformin sustained-release preparation and its preparation method and application
A technology for hydrogel metformin and sustained-release preparations, applied in the field of medical polymers, can solve the problems of low gastrointestinal membrane permeability, low bioavailability, etc., and achieves reduction of dosing frequency, improvement of compliance, and broad clinical application. Foreground effect
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Embodiment 1
[0025] Metformin drug sustained-release preparation P1 that rapidly disperses in water into an injectable thermogenic hydrogel, in which the polyester-polyether block copolymer is mPEG-PLGA diblock copolymer with a molecular weight of 550-1000 and a polymer mass of 2g, Metformin 1g.
[0026] Step (1): Put 2 g of polyester-polyether block copolymer in water, stir magnetically for 24 hours at 4° C., and prepare a polymer micelle solution with a polymer concentration of 20 wt %;
[0027] Step (2): Add 1g of metformin to the 20wt% polymer micelle solution formulated in step (1), dilute with water to a polymer concentration of 15wt%, place at 20°C and stir for 0.5h to form a metformin copolymer solution;
[0028] Step (3): The solution obtained in step (2) was frozen at -4°C for 24 hours, then placed in a freeze dryer and vacuum-dried for 48 hours to obtain a drug buffer that rapidly disperses in water into an injectable thermotropic hydrogel metformin. release preparations.
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Embodiment 2
[0031] Metformin drug sustained-release preparation P2 that rapidly disperses into an injectable thermogenic hydrogel metformin in water, wherein the polyester-polyether block copolymer is a PLGA-PEG-PLGA triblock copolymer with a molecular weight of 1850-1500-1850, The mass of polymer is 2g, metformin 2g.
[0032] Step (1): adding 2 g of metformin into physiological saline to form a metformin solution;
[0033] Step (2): Add 2g of polyester-polyether block copolymer to the 20wt% polymer metformin solution prepared in step (1), place it at 30° C. and stir for 24 hours to form a metformin copolymer solution;
[0034] Step (3): The solution obtained in step (2) was frozen at -80°C for 2 hours, then placed in a freeze dryer and vacuum-dried for 24 hours to obtain a drug buffer that rapidly disperses in water into an injectable thermotropic hydrogel metformin. release preparations.
[0035] The characteristics of the metformin hydrogel sustained-release preparation: it is a powd...
Embodiment 3
[0037] Metformin drug sustained-release preparation P3 that rapidly disperses in water into an injectable thermogenic hydrogel, wherein the polyester-polyether block copolymer is a PLGA-PEG-PLGA tri-block copolymer with a molecular weight of 1500-1000-1500 1 g of PLGA-PEG-PLGA, 1 g of PLGA-PEG-PLGA with a molecular weight of 1250-1500-1250, 0.1 g of metformin, and 0.2 g of calcium chloride.
[0038] Step (1): Place the block copolymers with two molecular weights in PBS together, stir magnetically at 4°C for 24 hours, and prepare a polymer micelle solution with a polymer concentration of 20 wt%.
[0039] Step (2): Dissolving 0.1g metformin and 0.2g calcium chloride in PBS to form metformin-calcium chloride aqueous solution;
[0040] Step (3): Add the metformin-calcium chloride solution in step (2) to the polymer solution in step (1), and add PBS to dilute to a polymer concentration of 5wt%, place it at 20°C and stir for 0.5h to form Metformin-calcium chloride copolymer solutio...
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