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Medicated leaven fermentation pretreatment process and medicated leaven

A six-divine song and pre-treatment technology, applied in the direction of plant raw materials, digestive system, plant/algae/fungus/moss components, etc., can solve the problems of large damage to active substances, ineffective effect, and slightly improved degree of improvement, and achieve The degree of fermentation is thorough, the effect of strengthening the spleen and stomach, and the effect of good enzyme activity

Active Publication Date: 2020-07-10
浙江桐君堂中药饮片有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition to being widely used in clinical prescriptions, Liushenqu is also the most widely used fermented traditional Chinese medicine in traditional Chinese medicine preparations; according to preliminary statistics, there are 41 prescriptions in the current "Chinese Pharmacopoeia" Contains Liushenqu, and there are as many as 326 pieces of Liushenqu in the standard prescription preparation issued by the Ministry; Chinese medicine formula granules, also known as Jianjian granules, are made of single Chinese medicine decoction pieces under the guidance of traditional Chinese medicine theory. It is prepared through four steps of water extraction, concentration, drying, and granulation. After the clinical prescription of traditional Chinese medicine is compatible, it is used by the patients themselves; There are huge differences, and there is no unified quality standard. Some commercially available Liushenqu have poor effects, and cannot achieve the functions of eliminating food, guiding stagnation, strengthening spleen and stomach
[0004] Chinese Patent Publication No. CN103006840A disclosed a preparation method of Liushenqu on April 3, 2013, which regulates each parameter of Liushenqu preparation, has stable product quality, reduces labor intensity, improves hygienic conditions, and is suitable for large-scale Production has significantly improved the quality of Liushenqu; but it also has the problem that it only regulates the traditional Liushenqu preparation process and does not further improve the traditional technology, and the prepared Liushenqu contains starch, crude protein, starch Parameters such as enzyme activity are only slightly better than the commercially available Liushenqu produced by traditional techniques
[0005] Chinese Patent Publication No. CN106389904A disclosed a Liushenqu and its preparation method on February 15, 2017. It uses Aspergillus sayi and Bacillus subtilis to replace the traditional Aspergillus oryzae used in the preparation of Liushenqu. In the preparation method, fermentation The process is easy to control and detect, the product quality is high, and the stability is better; but like the previous patent, the parameters such as starch, crude protein, and amylase activity in the prepared Liushenqu are compared with commercially available traditional processes. The effect of the Six Divine Comedy is not obvious
[0006] Chinese Patent Publication No. CN108653419A disclosed on October 16, 2018 a preparation method of the traditional Chinese medicine Liushenqu and its processing equipment. The method of decoction was used in the extraction process. High-temperature decoction would cause great damage to the active substances in the three raw materials. Although the treatment process was standardized, the effect of the finally prepared Liu Shenqu was better than that of the commercially available traditional process. Divine Comedy has been slightly improved, but the degree of improvement is only slightly improved

Method used

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  • Medicated leaven fermentation pretreatment process and medicated leaven

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A pre-treatment process for fermentation of Liushenqu includes the following steps:

[0035] a) Preparation: Prepare the raw materials in the following parts by weight: 100 parts of wheat flour, 90 parts of bran, 80 parts of red bean flour, 80 parts of bitter almond powder, 95 parts of fresh artemisia annua, 85 parts of fresh spicy polygonum, 95 parts of fresh Xanthium ;

[0036] b) Preparation of three fresh juices: chopped fresh Artemisia annua, Polygonum and fresh Xanthium, add 50wt% water of the total weight of Artemisia annua, Polygonum and fresh Xanthium, and add fresh A. annua 10wt% of pectinase, and adjusted the pH to 3.0, stirred at 27°C at 4 rpm for 4 hours, then adjusted the pH to 7.0, and then pressed to obtain three fresh juice

[0037] c) Enzymatic hydrolysis: adding 3wt% cellulase of the Sanxian juice to the prepared Sanxian juice, and agitating for 2 hours at 27°C and 4rpm to prepare the enzymatic hydrolyzing Sanxian juice;

[0038] d) Preparation: mix wheat fl...

Embodiment 2

[0043] A pre-treatment process for fermentation of Liu Shenqu, including the following steps:

[0044] a) Preparation: Prepare the raw materials according to the following parts by weight, 100 parts of wheat flour, 95 parts of bran, 85 parts of red bean flour, 85 parts of bitter almond powder, 100 parts of fresh artemisia annua, 90 parts of spicy polygonum, and 100 parts of fresh cocklebur ;

[0045] b) Preparation of three fresh juices: chopped fresh Artemisia annua, Polygonum and fresh Xanthium, add 55wt% water of the total weight of Artemisia annua, Polygonum and fresh Xanthium, and add fresh A. annua 12wt% pectinase, and adjust the pH to 3.2, stir for 4.5 hours at 29°C at 5 rpm, then adjust the pH to 7.2, and then squeeze to obtain three fresh juice;

[0046] c) Enzymatic hydrolysis: adding 4wt% cellulase of the Sanxian juice to the prepared Sanxian juice, and stirring for 2.5 hours at 29°C and 5rpm to prepare the enzymatically hydrolyzed Sanxian juice;

[0047] d) Preparation: m...

Embodiment 3

[0052] A pre-treatment process for fermentation of Liu Shenqu, including the following steps:

[0053] a) Preparation: Prepare the raw materials in the following parts by weight, 100 parts of wheat flour, 105 parts of bran, 95 parts of red bean flour, 95 parts of bitter almond flour, 100 parts of fresh artemisia annua, 110 parts of fresh and spicy polygonum, 100 parts of fresh Xanthium ;

[0054] b) Preparation of three fresh juices: chopped fresh Artemisia annua, Polygonum and fresh Xanthium, add 55wt% water of the total weight of Artemisia annua, Polygonum and fresh Xanthium, and add fresh A. annua 13wt% of pectinase, and adjust the pH to 3.3, stir for 5.5 hours at 30°C at 5 rpm, then adjust the pH to 7.3, and then press to obtain three fresh juices;

[0055] c) Enzymatic hydrolysis: add 6wt% cellulase of the Sanxian juice to the prepared Sanxian juice, and stir for 2.5 hours at 30°C and 5rpm to prepare the enzymatically hydrolyzed Sanxian juice;

[0056] d) Preparation: mix wheat ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines. The invention discloses a medicated leaven fermentation pretreatment process, wherein the process comprises the steps ofmaterial preparation, fresh juice preparation, enzymolysis, preparation, cutting, fermentation and the like. The invention also discloses medicated leaven prepared by the process. According to the fermentation pretreatment process provided by the invention, a series of pre-enzymolysis treatment is carried out between fermenting processes of medicated leaven, so that the nutritional components in the raw materials can be utilized by aspergillus oryzae more easily. The fermentation pretreatment process has the advantages of simple process, more thorough fermentation degree, short fermentation time and high fermentation efficiency. The prepared medicated leaven has rich digestive enzymes, and the digestive enzymes have high enzyme activity, so that the medicated leaven has good digestion andstagnation elimination, and spleen and stomach-strengthening effects.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a pre-treatment process for fermentation of Liushenqu and Liushenqu. Background technique [0002] Liushenqu, also known as Liuqu and Shenqu, was first recorded in "Theory of Medicine Properties", which says: "Sweet food, stagnation, nourish the spleen and stomach". It is bitter almond, chixiaodou, artemisia annua, cocklebur, spicy Polygonum and other medicinal materials are mixed with flour and wheat bran and fermented to form a koji. It is warm in nature, sweet and pungent, and mainly enters the spleen and stomach. It has the functions of digesting food and guiding stagnation, invigorating the spleen and stomach. It is used for the symptoms of external sentimental injury, fullness of the spleen, vomiting and relief. It is clinically used for the treatment of spleen and stomach weakness, diet stagnation, chest bloating, abdominal distension, and children's food a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K36/48A61K36/736A61K36/282A61K36/704A61K36/28A61P1/14
CPCA61K36/899A61K36/48A61K36/736A61K36/282A61K36/704A61K36/28A61P1/14A61K2236/19A61K2300/00
Inventor 申屠银洪倪善林汪玉军邱晓云郑炜
Owner 浙江桐君堂中药饮片有限公司
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