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Recombinant fibronectin-human-like collagen anti-aging composition and preparation method thereof

A human-like collagen and composition technology, applied in the field of protein, can solve the problems of susceptibility to bacterial infection, high cost, weak tensile strength, etc., and achieve good anti-aging effects and high safety effects

Inactive Publication Date: 2020-07-14
无锡美尚洁生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Fibronectin is widely used and has a huge market in the fields of medicine, cosmetics, and scientific research. However, the yield of natural, high-purity fibronectin extracted from human or animal blood and tissues is extremely limited and the cost is expensive.
Limits the application and production of FN in many aspects
[0005] Traditional collagen is mainly extracted from animal connective tissue, but there are risks such as animal-derived diseases, and the prepared collagen products have weak tensile strength, pure collagen degrades faster in the body, and there may be potential antigens At the same time, due to differences in the source of collagen, processing technology and raw material ratio, the nutritional content and feeding value of the product are also different, and the leather is not only exposed to many chemical substances during processing, but also susceptible to bacteria. infection, thus greatly limiting its potential application and development

Method used

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  • Recombinant fibronectin-human-like collagen anti-aging composition and preparation method thereof
  • Recombinant fibronectin-human-like collagen anti-aging composition and preparation method thereof

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preparation example Construction

[0028] A preparation method of recombinant fibronectin-human collagen anti-aging composition, the steps of the preparation method are:

[0029] a) Emulsifier 1, Emulsifier 2, Cetearyl Alcohol, Shea Butter, Jojoba Seed Oil, Hydrogenated Polyisobutene, Isononyl Isononanoate, Acticire, Phytosterol / Octyldodecanol Lauroyl Add glutamate, tocopheryl acetate, glyceramide ethanol methacrylate / stearyl alcohol methacrylate copolymer, polydimethylsiloxane, and DC-345 to the oil at 80-86°C according to the ratio Stir well in the phase pot and keep warm for 10 minutes;

[0030] b) Water, 1,3-propanediol, glycerin, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, lactobacillus / rice fermentation product, allantoin, β-glucan, trehalose, Sodium polyglutamate and sodium hyaluronate are added to the emulsification pot according to the ratio and stirred evenly. After the temperature of the emulsification pot is raised to 85-95°C, keep stirring for 30 minutes;

[0031] c) Pump the...

Embodiment 1

[0035] 3 parts of emulsifier 1, 0.5 parts of emulsifier 2, 2 parts of cetearyl alcohol, 1 part of shea butter, 2 parts of jojoba seed oil, 2 parts of hydrogenated polyisobutylene, 3 parts of isononyl isononanoate, Acticire 2 parts, Phytosterol / Octyldodecyl Lauroyl Glutamate 0.5 part, Tocopheryl Acetate 0.5 part, Glyceramide Ethanol Methacrylate / Stearyl Alcohol Methacrylate Copolymer 0.5 part, Polymer Add 1.5 parts of dimethylsiloxane and 2 parts of DC-345 into the oil phase pot at 85°C, stir evenly, and keep warm for 10 minutes;

[0036] b) 100 parts of water, 3 parts of 1,3-propanediol, 3 parts of glycerin, 0.8 parts of hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, 0.5 parts of lactobacillus / rice fermentation product, allantoin Add 0.15 parts, 0.05 parts of β-glucan, 2 parts of trehalose, 0.1 parts of sodium polyglutamate, and 0.05 parts of sodium hyaluronate into the emulsification pot and stir evenly. After the temperature of the emulsification pot is rai...

Embodiment 2

[0041] 3 parts of emulsifier 1, 0.5 parts of emulsifier 2, 2 parts of cetearyl alcohol, 1 part of shea butter, 2 parts of jojoba seed oil, 2 parts of hydrogenated polyisobutylene, 3 parts of isononyl isononanoate, Acticire 2 parts, Phytosterol / Octyldodecyl Lauroyl Glutamate 0.5 part, Tocopheryl Acetate 0.5 part, Glyceramide Ethanol Methacrylate / Stearyl Alcohol Methacrylate Copolymer 0.5 part, Polymer Add 1.5 parts of dimethylsiloxane and 2 parts of DC-345 into the oil phase pot at 85°C, stir evenly, and keep warm for 10 minutes;

[0042] b) 100 parts of water, 3 parts of 1,3-propanediol, 3 parts of glycerin, 0.8 parts of hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, 0.5 parts of lactobacillus / rice fermentation product, allantoin Add 0.15 parts, 0.05 parts of β-glucan, 2 parts of trehalose, 0.1 parts of sodium polyglutamate, and 0.05 parts of sodium hyaluronate into the emulsification pot and stir evenly. After the temperature of the emulsification pot is rai...

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Abstract

The present invention relates to the technical field of proteins, in particular to a recombinant fibronectin-human-like collagen anti-aging composition and a preparation method thereof. The composition comprises the following components in parts by weight: 1-5 parts of an emulsifier I, 0.1-1 part of an emulsifier II, 1-3 parts of cetostearyl alcohol, 0.5-2 parts of shea butter, 1-5 parts of simmondsia chinensis seed oil, 1-5 parts of hydrogenated polyisobutene, 1-5 parts of isononyl isononanoate, 1-5 parts of Acticire, 0.1-1 part of phytosterol / octyldodecanol lauroyl glutamate, 0.1-1 part of tocopherol acetate and 0.1-0.5 parts of a recombinant fibronectin-human-like collagen concentrated solution. Fine wrinkles are smoothed by taking a recombinant fibronectin-human-like collagen raw material with the high safety and the good anti-aging effect as a main functional agent, and supplementing various small molecular peptides. Sodium polyglutamate and glucan as the moisturizing components fully moisturize the skin based on the aging resistance to make the skin glossy, exquisite and elastic.

Description

technical field [0001] The invention relates to the technical field of proteins, in particular to a recombinant fibronectin-like human collagen anti-aging composition and a preparation method thereof. Background technique [0002] Fibronectin (FN for short) is a multifunctional protein present in human tissues and cells. It is a high-molecular, highly active glycoprotein and a protein dimer: composed of two similar subunits. , formed by cross-linking disulfide bonds at the C-terminus, the whole molecule is V-shaped, with a molecular weight of 440-450KDa. The molecular weight of each subunit is 220-250kDa. Fibronectin is found in human blood and cell surface. It has been clinically proven that fibronectin stimulates skin cells to produce collagen, thereby restoring skin elasticity. Fully regenerate skin cells in all layers: not only anti-aging, but also comprehensively repair red bloodshot and allergic skin. Comprehensively repair the cells of each layer of the skin: phago...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/88A61K8/73A61K8/65A61Q19/08A61Q19/00
CPCA61K8/64A61K8/88A61K8/73A61K8/65A61Q19/08A61Q19/00A61K2800/5922A61K2800/10A61K2800/85
Inventor 梁宗言
Owner 无锡美尚洁生物科技有限公司
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