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Preparation method of nano copper particles for treating inflammatory diseases

An inflammatory disease, nano-copper technology, applied in the field of medicine, can solve the problems of glomerular filtration membrane excretion, low catalytic efficiency, small specific surface area, etc., achieve super broad-spectrum antioxidant performance, mild conditions, The effect of simple synthesis process

Active Publication Date: 2020-07-17
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this Cu x The particle size of O nanomaterials is large, resulting in a small specific surface area and low catalytic efficiency. It needs to reach a microgram concentration to function, but high-concentration copper nanomaterials have certain toxicity to cells.
In addition, this Cu x O nanomaterials cannot pass through the glomerular filtration membrane and be excreted in urine, which has potential toxicity in vivo

Method used

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  • Preparation method of nano copper particles for treating inflammatory diseases
  • Preparation method of nano copper particles for treating inflammatory diseases
  • Preparation method of nano copper particles for treating inflammatory diseases

Examples

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Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Preparation of Nano Copper Particles for Treatment of Inflammatory Diseases

[0048] The preparation process is as follows:

[0049] 1) Weigh 0.0672g of anhydrous copper chloride, add it to 50mL of deionized water, stir it magnetically for 10 minutes to fully dissolve it, prepare a copper chloride solution with a molar concentration of 10mM, and place it in an oil bath at 80°C;

[0050] 2) Weigh 0.8806g of ascorbic acid, add it into 50mL of deionized water, and fully dissolve it to form an ascorbic acid solution with a molar concentration of 0.1M;

[0051] 3) Under magnetic stirring, slowly drop the ascorbic acid solution obtained in step 2) into the round-bottomed flask containing the copper chloride solution obtained in step 1 through the dropping funnel, the dripping speed is 3 seconds / drop, 80 ℃ constant temperature oil Under the condition of the bath, stir magnetically for 10 hours, and finally obtain a brown-yellow to brown-black suspension C;

[0052]...

Embodiment 2

[0052] 4) Centrifuge the suspension C obtained in step 3), the centrifugation speed is 8000 rpm, and the centrifugation time is 10 minutes, discard the precipitate, dialyze the supernatant with a dialysis bag with a molecular weight of 3500D for 48 hours, freeze Dry for 24 hours to obtain ultra-small diameter nano-copper particle powder with strong oxidation resistance. Example 2 Preparation of Nano Copper Particles for Treatment of Inflammatory Diseases

[0053] The preparation process is as follows:

[0054] 1) Weigh 0.0672g of anhydrous copper chloride, add it to 50mL of deionized water, stir it magnetically for 10 minutes to fully dissolve it, prepare a copper chloride solution with a molar concentration of 10mM, and place it in an oil bath at 80°C;

[0055] 2) Weigh 1.7612g of ascorbic acid, add it into 50mL of deionized water, and fully dissolve it to form an ascorbic acid solution with a molar concentration of 0.2M;

[0056] 3) Under magnetic stirring, slowly drop the...

Embodiment 3

[0057] 4) Centrifuge the suspension C obtained in step 3), the centrifugation speed is 8000 rpm, and the centrifugation time is 10 minutes, discard the precipitate, dialyze the supernatant with a dialysis bag with a molecular weight of 3500D for 48 hours, freeze Dry for 24 hours to obtain ultra-small diameter nano-copper particle powder with strong oxidation resistance. Example 3 Preparation of Nano Copper Particles for Treatment of Inflammatory Diseases

[0058] The preparation process is as follows:

[0059] 1) Weigh 0.0672g of anhydrous copper chloride, add it to 50mL of deionized water, stir it magnetically for 10 minutes to fully dissolve it, prepare a copper chloride solution with a molar concentration of 10mM, and place it in an oil bath at 80°C;

[0060] 2) Weigh 3.5224g of ascorbic acid, add it to 50mL of deionized water, and dissolve it fully to form an ascorbic acid solution with a molar concentration of 0.4M;

[0061] 3) Under magnetic stirring, slowly drop the a...

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Abstract

The invention discloses a preparation method of nano copper particles for treating inflammatory diseases. The method comprises the following step of: reacting a bivalent copper precursor such as copper chloride with ascorbic acid in deionized water to prepare the nano copper particles. The nano copper particles have strong oxidation resistance and ultra-small particle size, and can be used for treating inflammatory diseases such as acute kidney injury, acute liver injury or diabetic skin ulcer.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of ultra-small-diameter nano-copper particles for treating inflammatory diseases. Background technique [0002] Inflammation is the body's natural defense response to external stimuli such as infection, injury, and toxins. However, excessive, uncontrolled inflammation can lead to various diseases, such as cardiovascular disease, hepatitis, nephritis, delayed wound healing, etc. At present, the closely related relationship between inflammation and oxidative stress has been widely confirmed. The reactive oxygen species produced in the excessive inflammatory response can aggravate local tissue damage and lead to chronic inflammation. Therefore, the use of broad-spectrum antioxidants such as N-acetylcysteine ​​and acetyl-L-carnitine to scavenge reactive oxygen species is considered to be beneficial in the treatment of various inflammatory conditions such as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y40/00A61K33/34A61P29/00A61P13/12A61P1/16A61P3/10A61P17/02A61P39/06
CPCB22F9/24B82Y40/00A61K33/34A61P29/00A61P13/12A61P1/16A61P3/10A61P17/02A61P39/06B22F1/054B22F1/065
Inventor 邓君刘腾飞陈小元罗高兴毛峥伟
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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