Method for preparing glycyrrhetinic acid monoglucuronide by liquorice fermentation

A technology of glycyrrhetinic acid aldehyde and licorice aldehyde, which is applied in the field of microbial engineering, can solve problems such as affecting the consumption of GL by microorganisms, difficulty in product separation, and high price, and achieves suitable for large-scale production, simple operating parameters, and low production costs Effect
CN111485012AActive Publication Date: 2020-08-04JIANGXI SCI & TECH NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGXI SCI & TECH NORMAL UNIV
Publication Date
2020-08-04

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Abstract

The invention discloses a method for preparing glycyrrhetinic acid monoglucuronide (GAMG) by solid-state fermentation of liquorice. The method comprises the following steps of: with Glycyrrhiza uralensis as a main component of a solid culture medium. inoculating Chaetomium globosumTHS3 to carry out solid-state culture, wherein after fermentation is finished, the conversion rate of glycyrrhizic acid (GL) in liquorice can reach 90% or above, so that a mixture containing the GAMG and GL is formed and can be used for preparing a mixed sweetening agent containing GAMG or a GAMG monomer sweetening agent, wherein higher sweetness and solubility are achieved. According to the method, cheap and medicinally and edibly homologous liquorice is directly used as a raw material for solid-state fermentation; the high-yield and high-purity GAMG can be obtained through extraction, separation and purification and concentration and drying of a fermentation product, a target product can be prepared withoutfirstly extracting and separating to obtain GL or preparing beta-D-glucuronidase in advance, the process steps are few, the production cost is low, no pollution is caused, and the method is suitablefor large-scale production.
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Description

technical field

[0001] The invention relates to the field of microbial engineering, in particular to a method for preparing glycyrrhetinic acid monoglucuronide through solid-state fermentation technology. Background technique

[0002] Since excessive consumption of sugar can easily lead to dental caries, high blood pressure, diabetes and other diseases, it is an urgent need to find high-sweetness, low-calorie and safe natural sweeteners. Licorice is a plant of the genus Glycyrrhiza in the family Leguminosae, and is an important traditional Chinese herbal medicine with the same origin of medicine and food in my country. There are three original plants of licorice medicinal materials recognized by the "Chinese Pharmacopoeia", namely the roots and rhizomes of Ural licorice, bloated licorice and glabra. Currently, licorice extract is widely used around the world as a natural sweetener in food and beverages, as well as in pharmaceuticals and dietary supplements. Glycyrrhizic ac...

Claims

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