Medicinal application of epimedin C in treatment on diabetic liver injury

A technology for diabetes and liver damage, applied in the field of preparation of drugs for the treatment of diabetic liver damage, can solve the problem of not fully considering the taste and bioavailability of drugs, and it is difficult to reveal the material basis of epimedium in the treatment of diabetes and its complications To achieve the effect of improving the oxidative stress state of the liver, alleviating the disorder of lipid metabolism, and increasing the level of HDL-C

Active Publication Date: 2020-08-07
陕西新修本草健康产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] (1) In most existing technologies, Epimedium is combined with other medicinal materials to make Chinese patent medicines or traditional Chinese medicine compound preparations for the prevention and treatment of diabetes and its complications. No single use of Epimedium, Epimedium extract or Epimedium Report on the Treatment of Diabetes Mellitus and Its Complications by Flavonoids Monomers of Goatwort
[0009] (2) Most of the existing technologies use Epimedium or its extracts for the prevention and treatment of diseases such as diabetes and osteoporosis, and there are few reports on the use of Epimedium or its extracts in the treatment of diabetic liver injury complications
[0010] (3) In some prior art, the total flavonoids of Epimedium or Epimedium extract are combined with other traditional Chinese medicine extracts for the preven

Method used

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  • Medicinal application of epimedin C in treatment on diabetic liver injury
  • Medicinal application of epimedin C in treatment on diabetic liver injury
  • Medicinal application of epimedin C in treatment on diabetic liver injury

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0041] Example 1: Preparation of Chaohuoding C buccal tablets

[0042] A chaohuding C lozenge for the treatment of diabetic liver injury, and its prescription is made of the following mass percentage components: chaohuding C is 65%, arabinose is 9.8%, stevioside is 0.1%, microcrystalline fiber It is 15%, hypromellose is 9%, magnesium stearate is 1%, and absolute ethanol is 0.1%.

[0043] The preparation method of Chaohuoding C lozenge is:

[0044] Step 1, raw material weighing and pretreatment: according to the established mass percentage, respectively weigh Chaohuidine C, arabinose, stevioside, microcrystalline cellulose, hypromellose and magnesium stearate, and pass through a 60-mesh sieve.

[0045] Step 2. Preparation of soft material: take Chaohuidine C, add arabinose and steviol glycosides, use absolute ethanol as a wetting agent, stir well, add microcrystalline cellulose and hypromellose, stir evenly to make soft material.

[0046] Step 3. Granulation: Put the prepared soft mate...

Example Embodiment

[0048] Example 2

[0049] Example 2: Preparation of Chaohuoding C Coated Tablets

[0050] A Coated Tablet of Chaohuoding C for the treatment of diabetic liver injury, and its prescription is made of the following components by mass percentage: Chaohuding C is 49.8%, microcrystalline cellulose is 15%, and magnesium stearate is 1% , Hypromellose is 5%, steviol glycoside is 0.2%, glycerin is 1%, talc is 1%, and distilled water is 27%.

[0051] The preparation method of Chaohuoding C coated tablets is:

[0052] Step 1, raw material weighing and pretreatment: according to the established mass percentage, respectively weigh Chaohuidine C, microcrystalline cellulose, magnesium stearate and hypromellose, and pass through a 60 mesh sieve.

[0053] Step 2. Preparation of the tablet core: take Chaohuidine C, add microcrystalline cellulose and hypromellose, mix well, use distilled water as a binder to make a soft material, and then put the wet particles into 60℃ air-dried Dry in a box for about 1...

Example Embodiment

[0056] Example 3: Preparation of Chaohuoding C Hard Capsules

[0057] A Chaohuiding C capsule for treating diabetic liver injury is formulated with the following components in mass percentage: Chaohuiding C is 70%, and dietary fiber is 30%. In addition, several hard gelatin capsule shells for medicinal use are required.

[0058] The preparation method of Chaohuoding C hard capsule is:

[0059] Step 1, raw material weighing and pretreatment: Weigh Chaohuodin C and dietary fiber according to the established mass percentage, and pass through a 60-mesh sieve.

[0060] Step 2. Preparation of filling materials: Mix the chohuodin C and dietary fiber evenly.

[0061] Step 3, filling the capsule: the free inflow method is used to make the filling material enter the capsule shell, and then the capsule cap is fitted to obtain the Chaohuiding C hard capsule.

[0062] The following test examples further illustrate the therapeutic effect of Chaohuidine C on diabetic liver injury according to the pres...

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Abstract

The invention discloses a medicinal application of epimedin C in treatment on diabetic liver injury, and belongs to the technical field of biological medicines. The invention discloses that epimedin Ccan improve the cholesterol level of high-density lipoprotein in the liver of a diabetic model animal for the first time, the cholesterol level of low-density lipoprotein in the liver is reduced, theproblem of lipid metabolism disorder is relieved, a liver index is reduced, the activity of superoxide dismutase and glutathione peroxidase in the liver is enhanced, the content of malondialdehyde isreduced, the oxidative stress state of the liver is improved, normal forms and structures of hepatocytes and tissues are maintained, the activity levels of glutamic-pyruvic transaminase and glutamicoxalacetic transaminase in the liver are reduced, and liver function repair is promoted, so that the epimedin C can be used for preparing medicines for treating diabetic liver injury. The epimedin C is used for preparing the medicine for treating diabetic liver injury in the form of a medicinal preparation, and comprises buccal tablets, coated tablets and hard capsules. The invention provides a basis for treatment on diabetic liver injury, and also provides an idea for deep development and utilization of epimedium resources.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to the new effect of Epimedin C in treating complications of diabetic liver damage (abbreviated as diabetic liver damage), and its application in the preparation of drugs for treating diabetic liver damage. Background technique [0002] In recent years, the incidence of diabetes has increased year by year, and it has become the third major disease that seriously endangers human life and health after cardiovascular and cerebrovascular diseases and tumors. Diabetic complications are an important cause of disability and death in patients. As an important organ of sugar and lipid metabolism, the liver has a very close relationship with diabetes. Diabetes may cause damage to the liver in many ways, leading to complications of liver damage. Due to the atypical clinical symptoms of diabetic liver injury and other reasons, it has not been paid much attention by the medical community in ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P1/16A61P3/10A61K9/20A61K47/26A61K9/36A61K9/48A61K47/36
CPCA61K9/0056A61K9/2018A61K9/2826A61K9/4866A61K31/352A61P1/16A61P3/10
Inventor 张华峰周雪雪杨晓华薛梦莹
Owner 陕西新修本草健康产业有限公司
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