Preparation method and application of tissue repair promoting hydrogel with antitumor and antibacterial functions

Abstract

The invention belongs to the field of biomedical materials, and concretely relates to a preparation method and application of a tissue repair promoting hydrogel with antitumor and antibacterial functions. The preparation method of the hydrogel for promoting tissue repair mainly comprises the following steps: firstly, modifying chitosan with arginine, then physically compounding the modified chitosan with polydopamine and nano-hydroxyapatite to form an arginine modified chitosan-polydopamine / nano-hydroxyapatite solution, and finally, crosslinking the solution with a hydrophilic molecule (OHC-PEG-CHO) with aldehyde groups at two ends to form the hydrogel. The tissue repair promoting hydrogel constructed by the invention has a three-dimensional network structure, can inhibit the growth of tumor cells and bacteria, but does not obviously inhibit the growth of normal cells. When the hydrogel is used for defect filling or skin wound repair after skin or soft tissue tumor excision, the effects of efficiently inhibiting bacteria, promoting tissue repair, preventing scar tissue formation and inhibiting local tumor recurrence can be achieved, and the hydrogel has a good clinical applicationprospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to the preparation and application of a tissue repair-promoting hydrogel with both anti-tumor and antibacterial functions. Background technique [0002] Hydrogel (Hydrogel) is a hydrophilic polymer with water as the medium. It can swell significantly but cannot dissolve in water. It has a three-dimensional structure in space. The hydrophilic groups on the polymer chain form hydrogen bonds with water molecules. The connection makes it have a strong function of "locking" water, which can hold more than 90% of water, so the hydrogel has both solid and fluid properties, and can change from fluid to colloid under appropriate conditions. [0003] Chitosan is the deacetylated product of chitin, the only natural alkaline polysaccharide found so far, has no toxic side effects, has good biocompatibility and biodegradability, and is widely used in medicine, food, environmental p...

AI Technical Summary

Problems solved by technology

Because catechol has cell adhesion, it can change the tissue adhesion of chitosan, and can adsorb blood cells on the surface of the material to achieve better hemostatic effect; and improve the performance of chitosan and improve tissue affinity , and this material can be made into a new class of hemostatic sponge by freeze-drying, new dressings by spinning, or powder dressings by reverse flocculation, but this material cannot perform deep tissue repair, and there is no Inhibition of tumor recurrence

[0006] In summary, the existing chitosan hydrogels usually face problems such as poor cytocompatibility, difficulty in effective deep tissue repair, inability to effectively inhibit tumor recurrence, and limited practical applications.

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