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Functional integrated absorbable guided tissue regeneration membrane and preparation method thereof

A technology for guiding tissue regeneration and regenerating membranes, applied in tissue regeneration, prostheses, non-woven fabrics, etc., can solve the problems of lack of osteogenic activity and antibacterial properties, poor mechanical properties of degradable membranes, uncontrollable degradation cycle, etc. Good mechanical properties and biocompatibility, improving biocompatibility, preventing overgrowth

Inactive Publication Date: 2020-08-07
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a function-integrated absorbable guided tissue regeneration film and its preparation method, so as to overcome the poor mechanical properties, uncontrollable degradation cycle, low biological activity and lack of cost of the GTR degradable film in the prior art. Deficiencies in bone activity and antimicrobial properties

Method used

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  • Functional integrated absorbable guided tissue regeneration membrane and preparation method thereof
  • Functional integrated absorbable guided tissue regeneration membrane and preparation method thereof
  • Functional integrated absorbable guided tissue regeneration membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Weigh 0.8g of PLA (molecular weight 100,000, Jinan Daigang) and 0.2g of gelatin (25000-50000, Sigma) into 10ml of hexafluoroisopropanol solution, stir overnight on a magnetic stirrer, and configure A polymer solution A with a content of 10% was obtained.

[0043] Weigh 0.05g of nano-magnesium oxide particles (50nm, Aladdin) into polymer solution A, stir on a magnetic stirrer for 4h, ultrasonically vibrate for 60min, and then perform electrospinning to form a non-woven fabric with a size of 30x 30cm The cloth is the receiving device, the voltage is set to 15kV, the spinning rate is 3ml / h, the spinning is 2h, the receiving distance is 15cm, and an electrospun fiber membrane with a thickness of about 300μm is obtained.

[0044] Place the electrospun fiber membrane in a -80°C refrigerator for 30 minutes, and then dry it in a freeze dryer overnight to ensure that there is no residual solvent in the fiber membrane. The fiber membrane is recorded as nMgO-0.5 (indicating that ...

Embodiment 2

[0046] According to Example 1, the mass of nano-magnesium oxide particles was changed to 0.1 g, and the rest were the same as in Example 1 to obtain an electrospun fiber membrane with a thickness of about 300 μm, and the freeze-drying was also the same as in Example 1. The fiber membrane is recorded as nMgO-1 (meaning that the total mass ratio of the quality of nano magnesium oxide in the fiber membrane to the polylactic acid-gelatin is 10%).

Embodiment 3

[0048] According to Example 1, the mass of nano-magnesia particles was changed to 0.15 g, and the rest were the same as in Example 1 to obtain an electrospun fiber membrane with a thickness of about 300 μm, and the freeze-drying was also the same as in Example 1. The fiber membrane is recorded as nMgO-1.5 (representing that the total mass ratio of the quality of nano magnesium oxide in the fiber membrane to the polylactic acid-gelatin is 15%).

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Abstract

The invention relates to a functional integrated absorbable guided tissue regeneration membrane and a preparation method thereof. The regenerated membrane comprises a degradable artificially synthesized high-molecular material, a natural degradable high-molecular polymer and inorganic nanoparticles. The method comprises the following steps: dissolving the degradable artificially synthesized high-molecular material and the natural degradable high-molecular polymer in an organic solvent, stirring, adding inorganic nanoparticles, stirring, carrying out ultrasonic treatment, and carrying out electrostatic spinning. The regeneration membrane has good mechanical properties, biocompatibility, antibacterial property and osteogenic activity, and also has an obvious periodontal repair effect. The method has the advantages of wide material sources and low preparation cost, and has potential clinical application prospects.

Description

technical field [0001] The invention belongs to the field of guided tissue regeneration membrane and its preparation, in particular to a degradable periodontal guided tissue regeneration membrane with integrated antibacterial and osteogenic functions and a preparation method thereof. Background technique [0002] Periodontitis is one of the most common oral diseases in humans, affecting approximately 50-90% of the world's population, depending on its precise definition. Periodontitis is a chronic inflammatory disease caused by bacteria. If it is not treated properly, the inflammation will further intensify and spread deep into the periodontal tissue, resulting in the loss of connective tissue and alveolar bone around the teeth and irreversible recovery. Cause the loss of teeth, bring great inconvenience to people's daily life. The traditional clinical treatment of periodontal disease mainly focuses on controlling or preventing the progress of periodontitis, and cannot effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/46A61L27/58A61L27/54D01F1/10D01F8/02D01F8/14D04H1/413D04H1/4382D04H1/728
CPCA61L27/446A61L27/46A61L27/54A61L27/58A61L2300/102A61L2300/404A61L2400/12A61L2430/02D01F1/10D01F8/02D01F8/14D04H1/413D04H1/4382D04H1/728C08L67/04C08L89/00
Inventor 莫秀梅刘学哲
Owner DONGHUA UNIV
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