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Infant diaper dermatitis ointment and preparation method thereof

A technology for baby diapers and ointments, which is applied in the fields of pharmaceutical formulations, skin diseases, ointment delivery, etc. It can solve the problems of slow drug onset and poor permeability, and achieve good effects of reducing external damage, increasing permeability, and absorbing Effect

Active Publication Date: 2020-08-18
JOTM DAILY CHEM HANGZHOU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned prior art has simple ingredients, and the treatment is mainly achieved through the combination of the components of the comfrey extract and sesame oil. The overall formula has poor permeability and slow drug onset

Method used

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  • Infant diaper dermatitis ointment and preparation method thereof
  • Infant diaper dermatitis ointment and preparation method thereof
  • Infant diaper dermatitis ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-9

[0081] Embodiment 1-9: a kind of baby diaper dermatitis ointment, the component that comprises and corresponding percentage by weight are as shown in Table 1 (total amount is 100kg), and is prepared by the following steps:

[0082] Z1: Weigh the raw materials of Group A and put them into the emulsification pot, heat to 70°C, stir for 5 minutes at a stirring speed of 300r / min until transparent, and obtain mixture A;

[0083] Z2: Weigh the raw materials of Group B and put them into a stirring tank, heat to 70°C, dissolve and mix until transparent at a stirring speed of 200r / min to obtain a mixture B;

[0084] Z3: put the mixture B into the emulsification pot and mix it with the mixture A, homogenize at the speed of 2500r / min for 4min, and then mix at the speed of 600r / min, the total time of homogenization and stirring is 4min, and the mixture C is obtained;

[0085] Z4: Cool mixture C to 50°C, mix for 3 minutes at a stirring speed of 400r / min, and mix well;

[0086] Z5: Weigh t...

Embodiment 10

[0101] Embodiment 10: a kind of baby diaper dermatitis ointment, the difference with embodiment 9 is that the second restoration agent consists of 10% caprylic / capric triglycerides, 15% phytosterols, 9% glyceryl stearate , 30% Tocopheryl Acetate, 10% Hydrogenated Lecithin, 20% Bisabolol and 6% Licorice Root Extract.

Embodiment 11

[0102] Embodiment 11: a kind of baby diaper dermatitis ointment, the difference with embodiment 10 is that the second anti-inflammatory soothing agent is made of 60% hydroxyphenylpropionamide benzoic acid, 20% 1,2-pentanediol and the remainder composition of butanediol.

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PUM

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Abstract

The invention discloses infant diaper dermatitis ointment and a preparation method thereof. The ointment is prepared from the following components in percentage by weight: 35 to 48 percent of bis-diglycerol polyacyl adipate-2; 10-20% of mineral oil; 0.2-6% of a first relieving agent; 1-5% of white beeswax; 0.5%-3% of carrageenan oil; 0.1-1% of an emulsifier; 2.5-11% of a first repairing agent; 0.1-3% of a second repairing agent; 0.1 to 3 percent of phytosterol oleate; 2.01 to 9 percent of a second soothing agent; the balance water; 0.1-3% of a first anti-inflammatory soothing agent; 0.1 to 1 percent of a second anti-inflammatory relieving agent; 0.1-2% of a third anti-inflammatory soothing agent; 0.1-1% of a phellodendron amurense extract; 0.1 to 1 percent of beta-glucan; 1-5% of a skin protective agent; 1.5-2.5% of a skin enhancer; 0.2%-1.5% of a preservative; wherein the first soothing agent comprises melaleuca alternifolia leaf oil; the second soothing agent is prepared from dipotassium glycyrrhizinate accounting for 0.01 to 1 percent of the total weight of the ointment and gallnut extract accounting for 2 to 8 percent of the total weight of the ointment. The product provided bythe invention can be used for treating diaper dermatitis of infants, and has the advantages of quick response and good treatment effect.

Description

technical field [0001] The invention relates to the technical field of red buttock medicines, more specifically, it relates to a baby diaper dermatitis ointment and a preparation method thereof. Background technique [0002] Infant diaper dermatitis, commonly known as "red buttocks", is a skin inflammatory lesion that is a common skin disease in infants. It occurs in the area where the baby is wrapped in diapers, with localized flaky erythema or raw blisters. Infant diaper dermatitis is a common skin inflammation in newborn babies. It is mostly caused by children's blood-heated body, delicate skin, wet diaper soaked for too long, and hot and humid air steaming, causing skin burns. [0003] The Chinese invention with the publication number CN105616474A discloses a baby buttock cream and its preparation method, which includes comfrey extract, sesame oil, glycerin and hydroxypropyl distarch phosphate, and the weight percentage of the glycerol is 20% to 40%, The weight percenta...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K9/06A61K47/44A61P17/00A61K31/704A61K31/716A61K35/64
CPCA61K36/889A61K36/756A61K36/61A61K31/704A61K35/64A61K36/54A61K36/185A61K36/899A61K36/489A61K36/484A61K36/539A61K36/752A61K36/282A61K36/488A61K38/011A61K31/716A61K9/06A61K9/0014A61K47/44A61P17/00A61K2300/00Y02A50/30
Inventor 楼彪从云玲
Owner JOTM DAILY CHEM HANGZHOU CO LTD
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