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Membrane for guiding regeneration of oral bone tissue and preparation method thereof

A technology for bone tissue regeneration and oral cavity, which is applied in tissue regeneration, non-woven fabrics, textiles and paper making, etc. It can solve the problems of induced inflammation, loss of magnesium and polymer scaffolds, and surrounding tissue irritation, so as to accelerate the speed of bone healing, Improves recovery rate and suppresses inflammatory response

Active Publication Date: 2022-03-29
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But its disadvantage is that the raw materials of GBR membranes prepared by electrospinning technology are often high molecular polymer materials, which will produce acidic products during the degradation process, which will cause irritation to the surrounding tissues and even induce inflammation.
[0006] Metal and polymer belong to two different materials, and there must be an interface after the two are combined, which leads to the easy detachment of magnesium and polymer scaffolds

Method used

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  • Membrane for guiding regeneration of oral bone tissue and preparation method thereof
  • Membrane for guiding regeneration of oral bone tissue and preparation method thereof
  • Membrane for guiding regeneration of oral bone tissue and preparation method thereof

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preparation example Construction

[0033] A method for preparing a film for guiding oral cavity bone tissue regeneration according to the present invention comprises the following steps:

[0034] Step 1 Carve the pure magnesium or magnesium alloy foil into porous pure magnesium or magnesium alloy mesh 002, pretreat the porous pure magnesium or magnesium alloy mesh 002, then immerse in the degradable polymer solution, air-dry naturally and then hot press Processing, porous pure magnesium or magnesium alloy mesh can be made by a variety of different generalizations, for example: laser engraving technology can be used, the process parameters adopted for laser engraving are wavelength λ=1064nm, laser power P=20W, and the hole shape can be Regular hexagon, regular triangle, rhombus, square, circle and other geometric shapes, and the actual area of ​​the porous pure magnesium or magnesium alloy mesh is 20-40% of the area of ​​the pure magnesium or magnesium alloy foil, pure magnesium or magnesium alloy The thickness ...

Embodiment 1

[0043] (1) Using a magnesium plate with a purity of 99.9% as a material, it is hot-rolled to a thickness of 150 μm, and laser engraving technology is used to engrave regular hexagonal holes that account for 20% of the actual area and are evenly distributed on the foil.

[0044] (2) pickling with 5% glacial acetic acid for 30s, and annealing at 150°C for 20min after natural drying.

[0045] (3) Micro-arc oxidation treatment: at 12.5g / L Na 2 SiO 3 , 4.5g / L Na 3 PO 4 , in the electrode solution of 2.5g / L NaOH, the surface treatment was performed at a frequency of 450Hz and a current of 3.8A under direct current mode, the working voltage was increased to 260V, and the micro-arc oxidation treatment was performed for 15min; finally, the magnesium mesh was washed three times with deionized water and placed in Let dry naturally.

[0046] (4) Soak the magnesium mesh in a polycaprolactone (PCL) solution with a concentration of 0.1 g / mL and HFIP as a solvent for 60 min, take it out a...

Embodiment 2

[0051] (1) Using Mg-Zn alloy sheet with a magnesium content of more than 98% as raw material, it is hot-rolled at 200°C to a thickness of 200 μm, and laser engraving technology is used to engrave evenly distributed diamond-shaped holes on the foil that account for 30% of the actual area .

[0052] (2) pickling with 5% glacial acetic acid for 30s, and annealing at 180°C for 20min after natural drying.

[0053] (3) Micro-arc oxidation treatment: at 13.0g / L Na 2 SiO 3 , 5.0g / L Na 3 PO 4 , in the electrode solution of 2.5g / L NaOH, the surface treatment was performed at a frequency of 500Hz and a current of 3.8A under direct current mode, the working voltage was increased to 260V, and the micro-arc oxidation treatment was performed for 20min; finally, the magnesium mesh was washed three times with deionized water and placed in Let dry naturally.

[0054] (4) Soak the magnesium mesh in a polylactic-co-glycolic acid (PLGA) solution with a concentration of 0.12 g / mL and a solvent...

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Abstract

A film for guiding the regeneration of oral bone tissue and a preparation method thereof have good osteoinductivity and can control the degradation time of the film. Its composition includes a porous pure magnesium or magnesium alloy net, and a polymer spinning membrane composite spinning membrane is respectively arranged on the upper and lower sides. Preparation method: Carve pure magnesium or magnesium alloy foil into porous pure magnesium or magnesium alloy mesh, immerse in degradable polymer solution after pretreatment, and heat press after natural air drying; degradable medical grade polymer material and organic The solvent is configured as an electrospinning solution, and the polymer spinning film is formed by electrospinning, and the bottom surface of the porous pure magnesium or magnesium alloy mesh is pasted on the polymer spinning film before the solvent in the polymer spinning film is completely volatilized. On the membrane, the mass percentage of degradable medical-grade polymer materials in the electrospinning solution is 15‑18wt.%; the electrospinning solution is blended with magnesium particles to form a blended electrospinning solution, and the porous pure magnesium or magnesium alloy On the surface of the mesh, a composite spinning film is formed by electrospinning with a blended electrospinning liquid.

Description

technical field [0001] The invention belongs to the field of biomedical appliances, and in particular relates to a technique for guiding the regeneration of oral cavity bone tissue. Background technique [0002] With the development of materials and medical technology, oral implants are more and more widely used, but in practical applications, patients often encounter problems such as insufficient bone mass (height and thickness) and poor implant retention. According to the characteristics of bone and soft tissue growth, guided bone regeneration (GBR) or / and guided tissue regeneration (GTR) techniques are often used for bone augmentation. However, during the repair process, the growth rate of fibroblasts is much greater than that of bone cells. Therefore, it is necessary to implant a barrier film on the alveolar bone to prevent fibroblasts from growing into the bone defect and leave space for the growth of bone cells. Thus, the repair of the surgical field is realized. [...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/56A61L27/50A61L27/58A61L27/54A61L27/30A61L27/34D04H1/728
CPCA61L27/047A61L27/56A61L27/50A61L27/58A61L27/54A61L27/306A61L27/34D04H1/728A61L2430/02A61L2300/102A61L2300/404A61L2300/41A61L2300/412A61L2300/602C08L67/04C08L89/00
Inventor 白晶王先丽程兆俊张磊王会一薛烽
Owner SOUTHEAST UNIV
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