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A kind of dendritic tryptophan compound, its preparation method and its application as antibacterial agent

A compound, tryptophan technology, applied in the direction of antifungal agents, antibacterial agents, antiviral agents, etc., can solve the problems of poor antibacterial effect, achieve the effect of short reaction cycle, simple production process and low cost

Active Publication Date: 2022-07-01
WEIHAI CY DENDRIMER TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention aims at the problem that the existing antibacterial agent still has poor antibacterial effect when treating microorganisms with complex composition, and proposes a kind of antibacterial agent with simple preparation method, good compound antibacterial effect and broad-spectrum antibacterial property. Dendritic tryptophan compound, its preparation method and its application as antibacterial agent

Method used

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Experimental program
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Effect test

preparation example Construction

[0027] The present invention provides a method for preparing a dendritic tryptophan compound, comprising the following steps:

[0028] Add carboxyl-terminated polyamide-amine dendrimers and alkyl esterified tryptophan to hydrochloric acid and N,N-dimethylformamide solution, and react at 20℃-60℃ for 3-10 days. Compounds with amino acid groups;

[0029] Perform rotary evaporation drying, washing and drying on the above-mentioned compound containing a tryptophan group at the end, and the obtained residue is purified by high performance liquid chromatography to obtain a preliminary purified compound containing a tryptophan group at the end;

[0030] The preliminarily purified compound containing a tryptophan group at the end was dissolved in a THF solution, LiOH aqueous solution was added, stirred at 20° C.-60° C. for 3-10 days, and formic acid was added to adjust the pH to 2. The residue was purified by high performance liquid chromatography to obtain the purified dendritic tryp...

Embodiment 1

[0047] Dissolve 0.1 mol of first-generation PAMAM and 0.4 mol of succinic anhydride in 100 ml of dimethyl sulfoxide (DMSO) respectively, add the DMSO solution of PAMAM dropwise to the DMSO solution dissolved in succinic anhydride, and react at 40°C 2 days; the reaction was added dropwise to 10 times the volume of acetone for precipitation, washed with acetone for 3 times, dissolved in deionized water and dialyzed for 2 days and then freeze-dried to obtain carboxyl-terminated dendrimer 1 with a yield of 93%.

Embodiment 2

[0049] Dissolve 0.1 mol of the second-generation PAMAM and 1.6 mol of succinic anhydride in 100 ml of DMSO respectively, add the DMSO solution of PAMAM dropwise to the DMSO solution dissolved in succinic anhydride, and react at 40 °C for 3 days; Add to 10 times the volume of acetone for precipitation, wash with acetone for 3 times, dissolve in deionized water, dialyze for 2 days and freeze-dry to obtain carboxyl-terminated dendrimer 2 with a yield of 94%.

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Abstract

The invention discloses a dendritic tryptophan compound, its preparation method and its application as an antibacterial agent, and belongs to the technical field of dendritic polymer synthesis. Its technical scheme includes adding carboxyl-terminated polyamide-amine dendrimer and alkyl esterified tryptophan to hydrochloric acid and N,N-dimethylformamide solution, and reacting at 20°C-60°C for 3-10 days, A compound containing a tryptophan group at the end is obtained; the above-mentioned compound containing a tryptophan group at the end is subjected to rotary evaporation, washing and drying, and the obtained residue is purified by high performance liquid chromatography to obtain a preliminary purified tryptophan at the end. compounds with acid groups. The invention is applied to the field of antibacterial agents, solves the problem of poor antibacterial effect when the existing antibacterial agent treats microorganisms with complex composition, and has the characteristics of simple preparation method, good antibacterial effect and broad-spectrum antibacterial property.

Description

technical field [0001] The invention belongs to the technical field of dendritic polymer synthesis, and in particular relates to a dendritic tryptophan compound, its preparation method and its application as an antibacterial agent. Background technique [0002] Microorganisms include bacteria, fungi, viruses, and the like. Different types of microorganisms, different methods of removal, and different effects. Bacterial spores have strong heat resistance, so the sterilization effect is often based on killing the spores. The obvious bactericidal effect, low price, and easy use of chemical antibacterial agents make them widely used in the fields of preventing the spread of diseases and controlling infections. Chemical antibacterial agents are mainly divided into the following 8 categories according to their chemical structures: phenols, alcohols, aldehydes, chlorine-containing, iodine-containing, peroxides, quaternary ammonium salts, and guanidines. In addition, there are ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G73/02C08G83/00A61K31/787A61P31/04A61P31/10A61P31/12
CPCC08G73/028C08G83/004A61K31/787A61P31/04A61P31/10A61P31/12
Inventor 刘聪聪李武松
Owner WEIHAI CY DENDRIMER TECH
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