Iodine-supported titanium alloy medical component containing polycaprolactone (PCL)/povidone-iodine (PVP-I) surface layer and production method of iodine-supported titanium alloy medical component
A technology of povidone iodine and polycaprolactone, which is applied in the direction of pharmaceutical formulations, surface reaction electrolytic coatings, coatings, etc., can solve problems such as infection, and achieve good repeatability, high biological safety, and simple preparation process Effect
Active Publication Date: 2020-08-28
杭州明康捷医疗科技有限公司
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[0007] The purpose of the present invention is to provide an iodine-loaded titanium alloy medical component containing polycaprolactone / povidone-iodine surface layer with antibacterial properties for the implant infection problem caused by titanium alloy medical materials used in the field of surgical orthopedics and its Production Method
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Embodiment 1
[0034] 1. Polish and sandblast the material (provided by Zhejiang Kehui Medical Instrument Co., Ltd.) so that the surface roughness Ra value of the material is in the range of 0-0.4 microns. After pretreatment with acetone (≥99.5%), ethylene glycol (≥99.5%), ultrapure water, etc., the material is placed in a solution containing HF (≥40%, 20ml / L), HNO 3 (65.0~68.0%, 80ml / L), H 3 PO 4 (85%, 15ml / L) solution system for pickling for 15 minutes, and finally ultrasonically cleaned for 3 times, and dried.
[0035] 2. carry out micro-arc oxidation to the material of finishing step 1, and its reaction solution system is: calcium acetate (AR, 10g / L), calcium dihydrogen phosphate (AR, 10g / L), edetate disodium salt ( AR, 15g / L), calcium glycerophosphate (AR, 10g / L), the material is fixed on the anode side, the distance between the anode side and the cathode side is 25cm, the above reaction conditions are: voltage 300V, frequency 100HZ, accounting for The air ratio is 10%, the water tem...
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Abstract
The invention provides an iodine-supported titanium alloy medical component containing a polycaprolactone (PCL)/povidone-iodine (PVP-I) surface layer and a production method of the iodine-supported titanium alloy medical component. An iodine containing coating is fixed to a titanium alloy by micro-arc oxidation reaction and surface iodine modification, and a high polymer composite structure is constructed on the structure, so that stable antibacterial performance is obtained; a material prepared by the technology has a more remarkable broad-spectrum antibacterial function, and the antibacterial effective component is iodine; besides, the defects that the iodine on the surface of the material is instable and prone to volatilization by constructing a PCL/PVP-I surface layer structure are overcome, and the stability of the antibacterial performance of the material is guaranteed; and besides, with gradual degradation of the surface layer structure, the iodine under the surface layer structure is gradually released, and the effective antibacterial duration of the material is also prolonged to a certain extent. The iodine-supported titanium alloy medical component can effectively reduceearly-stage infection and related complications in a surgery using a titanium alloy implant at present.
Description
technical field [0001] The invention relates to an iodine-loaded titanium alloy medical part containing polycaprolactone / povidone-iodine surface layer and a manufacturing method thereof. The iodine-loaded titanium alloy medical part has excellent, stable and long-term antibacterial performance. Background technique [0002] With the development of medical material technology, the scope of application and usage of medical implants are increasing year by year worldwide. Therefore, related infections caused by implants have become an unavoidable and difficult problem for clinicians. At present, clinically, systemic antibiotics are mainly used to treat such infections. However, this treatment method requires long-term and sufficient antibiotic application, which will cause the imbalance of normal flora in the human body, superinfection, and life-threatening in severe cases. In addition, when an implant-related infection occurs, the local blood supply at the infection lesion is...
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IPC IPC(8): A61L27/06A61L27/30A61L27/34A61L27/56A61L27/54A61L27/58C25D9/08C25D11/02C25D11/26
CPCA61L27/06A61L27/306A61L27/34A61L27/54A61L27/56A61L27/58A61L2300/106A61L2300/604A61L2400/18A61L2420/08A61L2430/02C25D9/08C25D11/026C25D11/26C08L67/04C08L39/06
Inventor 叶招明滕王锶源刘安王翊凯方亮
Owner 杭州明康捷医疗科技有限公司
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