Nano iron sulfide with dual functions of inhibiting bacteria and slowly releasing hydrogen sulfide as well as preparation method and application thereof

An iron sulfide and nanotechnology, applied in the field of nanomaterials, can solve the problems of product instability, poor biocompatibility, single antibacterial function, etc., and achieve the effects of stable properties, good dispersibility, and wound healing promotion.

Active Publication Date: 2020-09-04
YANGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, at present, inorganic nanomaterials also have some defects, such as unstable products, poor biocompatibility, and only a single antibacterial function.

Method used

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  • Nano iron sulfide with dual functions of inhibiting bacteria and slowly releasing hydrogen sulfide as well as preparation method and application thereof
  • Nano iron sulfide with dual functions of inhibiting bacteria and slowly releasing hydrogen sulfide as well as preparation method and application thereof
  • Nano iron sulfide with dual functions of inhibiting bacteria and slowly releasing hydrogen sulfide as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation and characterization of nano-iron sulfide Example 1: Dissolve 0.5g of polyvinylpyrrolidone (molecular weight: 10,000) in 20mL of ethylene glycol, and add 0.2g of FeCl after fully dissolved 3 .6H 2 O, 3.6g of sodium acetate solution (0.1M, pH4.5), and 1g of L-cysteine, stirred evenly by magnetic force. All the reaction solution was poured into a 50 ml polytetrafluoroethylene reactor, transferred to an oven, and reacted at 200° C. for 16 hours. After the reaction product is naturally cooled to room temperature, it is centrifuged, washed three times with absolute ethanol, freeze-dried in a vacuum, and finally obtains nanometer iron sulfide. Scanning electron microscope (SEM), transmission electron microscope (TEM) characterizes product (see figure 1 ).

Embodiment 2

[0033] Preparation and characterization example 2 of nano-iron sulfide: Dissolve 1.0g of polyvinylpyrrolidone (molecular weight: 10,000) in 20mL of ethylene glycol, and add 0.2g of FeCl after fully dissolved 3 .6H 2 O, 3.6g of sodium acetate solution (0.1M, pH4.5), and 0.5g of L-cysteine, stirred evenly by magnetic force. All the reaction solution was poured into a 50 ml polytetrafluoroethylene reactor, transferred to an oven, and reacted at 200° C. for 24 hours. After the reaction product is naturally cooled to room temperature, it is centrifuged, washed three times with absolute ethanol, freeze-dried in a vacuum, and finally obtains nanometer iron sulfide.

Embodiment 3

[0035] Preparation and characterization of nano-iron sulfide Example 3: Dissolve 0.5g of polyvinylpyrrolidone (molecular weight: 10,000) in 20mL of ethylene glycol, and add 0.2g of FeCl after fully dissolved 3 .6H 2 O, 3.6g of sodium acetate solution (0.1M, pH4.5), and 1g of thiourea, stirred evenly by magnetic force. All the reaction solution was poured into a 50 ml polytetrafluoroethylene reactor, transferred to an oven, and reacted at 200° C. for 16 hours. After the reaction product is naturally cooled to room temperature, it is centrifuged, washed three times with absolute ethanol, freeze-dried in a vacuum, and finally obtains nanometer iron sulfide.

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Abstract

The invention discloses nano iron sulfide with dual functions of inhibiting bacteria and slowly releasing hydrogen sulfide as well as a preparation method and application thereof, and the preparationmethod comprises the following steps: uniformly mixing an iron source, a sulfur source and polyvinylpyrrolidone in a solution, then carrying out solvothermal reaction, and after the solvothermal reaction is finished, cooling, separating, washing and drying to obtain the nano iron sulfide. The nano iron sulfide can induce bacteria to generate reactive oxygen species (ROS), destroy lipid, protein, DNA and other structures of the bacteria to affect the functions of the bacteria, inhibit the activity of bacterial glyceraldehyde-3-phosphate dehydrogenase (GAPDH), promote bacterial cell wall shedding and degradation, cause bacterial death, and effectively inhibit the formation of bacterial biofilms. Glutathione can induce the nano iron sulfide to slowly release the hydrogen sulfide and promote HUVEC cell migration and angiogenesis, and has a certain value for bacterial infection and tissue repair.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to nanoscale iron sulfide with dual functions of antibacterial and slow release of hydrogen sulfide, its preparation method and application. Background technique [0002] Bacterial infection is one of the high-incidence diseases in the world, and it is increasing year by year, and the harm to human health is also increasing. Broad-spectrum antibiotics can treat the vast majority of bacterial infections, but a group of highly resistant bacteria survive. Bacterial drug resistance and drug-resistant bacterial infection are the great challenges facing the field of bacterial disease treatment in the 21st century. With the increasing application of antibacterial drugs, the problem of drug resistance is becoming more and more serious, which makes the treatment of bacterial diseases fail, leading to the increase of morbidity and mortality and the increase of drug co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/12B82Y30/00A61K47/58A61K33/26A61P31/04A61P17/02
CPCC01G49/12B82Y30/00A61K47/58A61K33/26A61P31/04A61P17/02C01P2004/03C01P2004/04Y02A50/30
Inventor 许卓斌张唯高利增李丹丹程璐
Owner YANGZHOU UNIV
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