Method for preparing chloramphenicol

A technology of chloramphenicol and coenzyme, which is applied in the field of preparation of chloramphenicol, can solve the problems of high environmental hazards, cumbersome disassembly steps, and increased reaction steps, and achieve the effects of cost reduction, mild conditions, and simple operation
CN111662937AActive Publication Date: 2020-09-15湖南引航生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
湖南引航生物科技有限公司
Publication Date
2020-09-15

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Abstract

The invention provides a method for preparing chloramphenicol. (2S,3R)-p-nitrophenyl serine is prepared from p-nitrobenzaldehyde and L-threonine which are low in price and are easy to obtain under action of transaldolase, and a target product chloramphenicol is obtained through reduction and dichloroacetylation of the amino acid intermediate.
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Description

technical field

[0001] The invention relates to a method for preparing chloramphenicol, which belongs to the technical fields of biopharmaceuticals and biochemical industries. Background technique

[0002] Chloramphenicol is one of the broadest-spectrum antibiotics currently on the market. Its antibacterial mechanism is to bind to the 50S subunit of the ribosome and inhibit peptidyltransferase, thereby inhibiting protein synthesis. It can effectively control most Gram-negative and positive bacteria, influenza bacilli, pertussis bacilli, Shigella, Escherichia coli, Klebsiella pneumoniae, Proteus, Pseudomonas aeruginosa, Rickettsia, Chlamydia trachomatis, etc. It is widely used in the field of biomedicine, so exploring a mild, efficient and economical method to prepare chloramphenicol has attracted the attention of chemical and biological workers.

[0003] Chloramphenicol, its structural formula is as follows:

[0004]

[0005] The current method for industrial preparatio...

Claims

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