Application of 2-bromopalmitate in preparation of drugs for prevention and treatment of bone loss related diseases

A bromopalmitic acid, bone loss technology, applied in the field of medicine, can solve the problems of kidney toxicity, mandibular osteonecrosis, transient "flu-like" symptoms, etc.
CN111789833AInactive Publication Date: 2020-10-20SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2020-10-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of 2-bromopalmitate (2-BP) in preparation of drugs for prevention and treatment of bone loss related diseases, and belongs to the technical field of medicine. The invention, for the first time, clearly defines that 2-BP can inhibit osteoclast differentiation process of BMMs stimulated by RANKL through various experimental techniques, including tartrate resistantacid phosphatase staining, phalloidin fluorescence staining, bone lamella bone resorption function evaluation, reverse transcription real-time fluorescence quantitative PCR, Western blot, etc. In addition, the invention clearly states that 2-BP also has effects in inhibiting osteoclast differentiation and activation in vivo, and 2-BP can significantly alleviate the pathological process of massivebone loss caused by estrogen deficiency through the establishment of a mouse model of ovariectomy-induced osteoporosis, thus providing experimental data basis in vivo for the role of 2-BP in the prevention and treatment of bone loss related diseases.
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Description

technical field

[0001] The invention relates to the application of 2-bromopalmitic acid in the preparation of medicines for preventing and treating diseases related to bone loss, and belongs to the technical field of medicine. Background technique

[0002] As an important part of the motor system, bone provides structural support and protection for the body, and participates in physiological processes such as hematopoiesis, calcium metabolism, and endocrine regulation in the body. Bone remodeling occurs throughout a person's life, and most diseases related to bone metabolism affect the bone remodeling process. Bone remodeling in a normal body depends on the direct dynamic balance between bone resorption mediated by osteoclasts and bone formation mediated by osteoblasts, and an imbalance between the two will cause excessive bone formation and sclerosis-related diseases Or bone formation imperfection, excessive resorption-related diseases. Osteoporosis (Osteoporosis) is a sy...

Claims

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