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Optical fiber sensing micro-fluidic chip propofol online derivatization detection system and method

A detection system and micro-sensing technology, applied in chemical instruments and methods, fluid controllers, color/spectral characteristic measurement, etc., can solve complex and time-consuming processes, lack of real-time detection methods for anesthetic drugs, and lack of better anesthesia depth objective evaluation

Pending Publication Date: 2020-10-23
XINJIANG MEDICAL UNIV
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Problems solved by technology

Due to the limitation of the rigid structure of the analytical instrument, the current in vivo drug concentration analysis method is the analysis and detection of offline sampling, and the process is complicated and time-consuming, which is not conducive to obtaining the analysis results in time, and there is a problem of lagging drug information feedback in the body. Lack of good objective evaluation of controls
[0003] The new technology and new method for the real-time detection of drug components in the body is a hot research topic at home and abroad. At present, there is still a lack of feasible real-time detection methods for anesthetic drugs. A fiber-optic sensing microfluidic chip is proposed for the on-line derivatization detection of propofol systems and methods

Method used

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  • Optical fiber sensing micro-fluidic chip propofol online derivatization detection system and method
  • Optical fiber sensing micro-fluidic chip propofol online derivatization detection system and method
  • Optical fiber sensing micro-fluidic chip propofol online derivatization detection system and method

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Embodiment

[0029] Example: see Figure 1-3 ,

[0030] Step 1: Pretreatment of propofol in biological samples:

[0031] Precisely aspirate 0.5 mL of plasma sample containing propofol, dilute the sample with the same volume of 4% phosphoric acid. The HLB solid phase extraction cartridges are activated with 1 mL of methanol, equilibrated with 1 mL of water, and then 1 mL of phosphoric acidified plasma sample is added to the solid Phase extraction cartridge, rinse once with 1mL water, and then use 1mL containing 1% KHCO 3 Acetonitrile-water (1:9) was eluted twice, and finally eluted twice with 0.5 mL methanol, and the eluates were combined and collected.

[0032] Step 2: Investigation of linear range:

[0033] Accurately measure 5 aliquots of 490μL of propofol blank plasma and add 10μL of propofol series concentration standard solution to make the blood concentration 1.0, 3.0, 6.0, 9.0, 12.0, 15.0, 18.0μg / mL. The step 1 processing method is used for sample pre-processing, and then online derivatiz...

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Abstract

The invention discloses the technical field of rapid drug detection, and specifically relates to an optical fiber sensing micro-fluidic chip propofol online derivatization detection system and method.The system comprises an injection pump, a micro-fluidic mixing chip and a Z-shaped flow cell; online derivatization of a sample and a derivatization reagent is performed by adopting the micro-fluidicmixing chip, and the flow velocity and the flow rate of the reagent can be accurately controlled, so that detection can be completed by using a trace amount of the sample and the reagent; on-line detection is carried out by adopting an optical fiber sensing technology, and an optical signal is transmitted through an optical fiber, so that the instrument structure is simplified, the instrument size is reduced, and the whole analysis system is miniaturized, portable and suitable for on-site rapid detection; an online derivatization technology is adopted for rapid detection of a biological sample, the detection sensitivity and accuracy are improved through derivatization, and the problem that spectrum detection is easily interfered by other impurities in the sample is solved.

Description

Technical field [0001] The invention relates to the technical field of drug rapid detection, and the specific field is an online derivatization detection system and method for propofol with optical fiber sensing microfluidic chip. Background technique [0002] The immediate detection of anesthetics is a long-term clinical need. Excessive use of anesthetics causes circulatory and respiratory depression, while insufficient use leads to pain during the operation. At present, the control and adjustment of drug doses mainly rely on clinical experience and the monitoring of patient signs, and the metabolism of drugs varies greatly from individual to individual. The control and adjustment of drug doses are essential to the rational, safe and effective medication. The key depends on Timely and individualized feedback on the behavior of drugs in the body, the concentration of drugs in the body is the most important auxiliary information. Due to the limitations of the rigid structure of t...

Claims

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Application Information

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IPC IPC(8): G01N21/33G01N21/31B01L3/00
CPCB01L3/5027B01L3/502715B01L3/50273B01L2300/0654B01L2400/0475G01N21/31G01N21/33
Inventor 李莉刁娟娟刘瑞
Owner XINJIANG MEDICAL UNIV
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