Albumin adhesive and preparation method thereof

Abstract

The invention provides an albumin adhesive and a preparation method thereof. The albumin adhesive comprises bovine serum albumin, an acrylamide monomer, a first cross-linking agent and a second cross-linking agent. The strength of the bonding between the dual-network cross-linked albumin adhesive disclosed by the invention and tissues can be enhanced; the albumin adhesive has relatively strong elasticity and mechanical tensile property, and is controllable in forming process.

Description

technical field [0001] The invention belongs to the technical field of adhesives, in particular to an albumin adhesive and a preparation method thereof. Background technique [0002] With the advancement of medical technology, the clinical demand for soft tissue adhesives is increasing. According to statistics, more than 4 million surgical operations are performed every year in the world. Surgical sutures or fibers are traditionally used to suture surgical wounds, but a series of problems such as complications caused by air or body fluid leakage have caused serious harm. It may even endanger the life of the patient. As early as the 1950s, people used tissue adhesives to solve the serious problems caused by surgical sutures. [0003] Tissue adhesive is an adhesive that connects two or more materials together through interface adhesion and material cohesion, and is used for tissue bonding instead of surgical sutures. [0004] Protein-based adhesives have been paid attention...

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Problems solved by technology

[0004] Protein-based adhesives have been paid attention to by scholars because of their easy-to-obtain raw materials, low price, and good bonding performance. Currently, protein-based adhesives for clinical use mainly include fibrin-based adhesives, albumin-based adhesives, and gelatin-based adhesives. Adhesives, etc., fibrin adhesives are adhesives made from human fibrinogen and human thrombin, which have been widely used in cardiothoracic surgery, liver surgery and other surgical operations, but still There are disadvantages caused by insufficient mechanical strength, such as shortage of human blood sources, risk of virus transmission, and long production cycle.

Later, people studied albumin-glutaraldehyde and gelatin-resorcinol-formaldehyde adhesives, which showed that this type of adhesive has a certain bonding strength and is widely used in clinical aortic dissection arterial surgery, but this Adhesives still have disadvantages such as poor mechanical properties and insufficient bonding strength. Therefore, it is urgent to develop tissue adhesives with high mechanical strength, good bonding performance, and high biological safety in clinical practice.

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