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A kind of composite dressing capable of rapid hemostasis and preparation method thereof

A rapid and complex technology, applied in the field of medical supplies, can solve the problems of complex preparation methods, irritation caused by the human body, and slow hemostasis speed, and achieve the effect of simple components, reducing irritation, and improving antibacterial performance

Active Publication Date: 2022-04-19
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent application CN108066809A discloses a bacteriostatic and hemostatic dressing, which comprises the following components: hyaluronic acid, polyvinyl alcohol, collagen, silk fibroin powder, chitosan, glycerin and sulfadiazine silver salt , has good biocompatibility, dialysis, hemosucking, antibacterial, anti-adhesion and mechanical properties, high comfort, the sulfadiazine silver salt used effectively improves the antibacterial performance of the dressing, reduces the wound The probability of infection, however, the sulfadiazine silver salt in the antibacterial hemostatic dressing will cause certain stimulation to the human body, and the hemostatic speed of the antibacterial hemostatic dressing is slow, and because there are many components
The preparation method is complicated and the cost is higher
[0005] In summary, the existing hemostatic materials generally have the disadvantages of easy stimulation to the human body, high cost, and slow hemostasis speed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The composite dressing capable of rapidly stopping bleeding is composed of the following components and parts by weight: 10 parts of chitosan, 30 parts of sodium carboxymethylcellulose, 2 parts of glycerin, 0.5 parts of mannitol, 5 parts of silver ion complex, and 20 parts of linking agent; the crosslinking agent is composed of sodium borate, zirconate and glutaraldehyde in a weight ratio of 5:1:12. Wherein, the preparation steps of silver ion complex are:

[0033] A1. Add N-methylpyrrolidine, sodium fluoroborate, acetone, and n-butane bromide in a ratio of 2mol:1mol:1000mL:1mol into the reaction flask, pass nitrogen gas for 30 minutes, nitrogen protection, and stir at 30°C for 24 hours to obtain The reaction solution I is obtained by filtering the reaction solution I to obtain a filtrate, and the filtrate is distilled under reduced pressure to obtain an ionic liquid;

[0034] A2, the ionic liquid obtained in step A1 is added in hydroquinone, magnetically stirred to mi...

Embodiment 2

[0041]The composite dressing capable of rapidly stopping bleeding is composed of the following components and parts by weight: 20 parts of chitosan, 50 parts of sodium carboxymethylcellulose, 5 parts of glycerin, 1 part of mannitol, 6 parts of silver ion complex, and 30 parts of linking agent; the crosslinking agent is composed of sodium borate, zirconate and glutaraldehyde in a weight ratio of 7:3:15. Wherein, the preparation steps of silver ion complex are:

[0042] A1. Add N-methylpyrrolidine, sodium fluoroborate, acetone, and n-butane bromide with a ratio of 2.4mol:1mol:1000mL:1mol into the reaction flask, blow nitrogen for 1 hour, and stir under nitrogen protection for 18 hours at 35°C Obtain reaction solution I, obtain filtrate after filtering reaction solution I, obtain ionic liquid by depressurizing distillation of filtrate;

[0043] A2, the ionic liquid obtained in step A1 is added in hydroquinone, magnetically stirred to mix uniformly to obtain a mixed solution, sil...

Embodiment 3

[0050] The composite dressing capable of rapidly stopping bleeding is composed of the following components and parts by weight: 15 parts of chitosan, 40 parts of sodium carboxymethylcellulose, 3 parts of glycerin, 0.8 parts of mannitol, 5.5 parts of silver ion complex, and 25 parts of linking agent; the crosslinking agent is composed of sodium borate, zirconate and glutaraldehyde in a weight ratio of 6:2:13. Wherein, the preparation steps of silver ion complex are:

[0051] A1. Add N-methylpyrrolidine, sodium fluoroborate, acetone, and n-butane bromide at a ratio of 2.5mol:1mol:1000mL:1mol to the reaction flask, pass nitrogen gas for 2 hours, nitrogen protection, and stir for 12 hours at 33°C Obtain reaction solution I, obtain filtrate after filtering reaction solution I, obtain ionic liquid by depressurizing distillation of filtrate;

[0052] A2, the ionic liquid obtained in step A1 is added in hydroquinone, magnetically stirred to obtain a mixed solution evenly mixed, silve...

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Abstract

The invention belongs to the field of medical supplies, in particular to a composite dressing that can quickly stop bleeding and a preparation method thereof. The composite dressing that can quickly stop bleeding provided by the present invention comprises the following components and their parts by weight: 10-20 parts of chitosan, 30-50 parts of sodium carboxymethyl cellulose, 2-5 parts of glycerin, and 0.5- parts of mannitol 1 part, 5-6 parts of silver ion complex, and 20-30 parts of cross-linking agent. The composite dressing that can quickly stop bleeding provided by the invention can quickly stop bleeding, has no irritation to the human body, does not cause wound infection, and has low cost, remarkable curative effect and strong practicability.

Description

technical field [0001] The invention belongs to the field of medical supplies, and in particular relates to a composite dressing capable of rapidly stopping bleeding and a preparation method thereof. Background technique [0002] In clinical medicine, blood vessels after puncture or trauma need effective hemostasis, such as radial artery hemostasis after puncture or traumatic coronary angioplasty, or fistula hemostasis after hemodialysis treatment, during trauma and trauma surgery or war wound surgery There will be bleeding in the middle, and the bleeding needs to be stopped in time. In the process of our life, there are also many times when we need to stop bleeding, such as accidental cuts, scratches, etc. Therefore, finding materials that can quickly stop bleeding is of great help to our health. [0003] At present, there are many kinds of hemostatic materials that have been disclosed, and the most common forms are dressing form, liquid form and hemostatic clip. Among th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/46A61L15/42A61L15/18
CPCA61L15/46A61L15/42A61L15/18A61L2400/04A61L2300/104A61L2300/404
Inventor 车七石刘少辉
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD