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A two-component cross-linked medical composite material, its preparation method and application

A composite material, two-component technology, applied in the field of medicine, can solve the problems of large rejection possibility, insufficient adhesion, poor adaptability, etc., and achieve the effect of strong adaptability and tight sealing to protect the wound surface.

Active Publication Date: 2021-11-16
杭州仪文生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention proposes a two-component cross-linked medical composite material, its preparation method and application, which solves the problems of insufficient adhesion, poor adaptability, greater possibility of rejection and easy swelling of biological materials in the prior art.

Method used

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  • A two-component cross-linked medical composite material, its preparation method and application
  • A two-component cross-linked medical composite material, its preparation method and application
  • A two-component cross-linked medical composite material, its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0058] Obtaining of amino reactive group-terminated branched compounds (first component starting material):

[0059] 1. G2-8NH 2 Branched polyamidoamine, with 8 branched chains, each branched chain end contains an amino active group, the molecular structure is as follows figure 1 As shown, algebra: G2 (second generation), purchased from Weihai Chenyuan Molecular New Material Co., Ltd.

[0060] 2. G3-16NH 2 Branched polyamidoamine, with 16 branched chains, each branched chain end contains an amino active group, the molecular structure is as follows figure 2 As shown, algebra: G3 (third generation), purchased from Weihai Chenyuan Molecular New Material Co., Ltd.

[0061] 3. G2-8NH 2 Branched polylysine has 8 branched chains, and each branched chain end contains an amino active group. The molecular structure is as follows image 3 As shown, algebra: G2 (second generation), purchased from Weihai Chenyuan Molecular New Material Co., Ltd.

[0062] 4. G3-16NH 2 Branched polyl...

Embodiment 2

[0064] Preparation of branched compounds terminated by mercapto reactive groups (first component raw material)

[0065] 1. Preparation of G2-8SH branched polyamide-amine:

[0066] Preparation of main raw materials: G2-8NH 2 Branched polyamidoamine, N-acetylcysteine, cysteine, N,N'-dicyclohexylcarboimide (DCC) (CAS No.: 538-75-0), 1-hydroxy Benzotriazole (HOBT) (CAS No.: 2592-95-2).

[0067] Preparation principle: Carboxyl groups on N-acetylcysteine ​​and cysteine ​​and G2-8NH 2 The amino group on the branched polyamide-amine reacts under the catalysis of DCC and HOBT catalysts to form a new amide bond (-CO-NH-) to generate a G2-8SH branched polyamide terminated with a thiol active group at the end - amine compounds.

[0068] making process:

[0069](1) 160 mass parts of N-acetylcysteine, 40 mass parts of cysteine ​​and 1500 mass parts of solvent N, N-dimethylformamide (DMF) are mixed and stirred for dissolution;

[0070] (2) Continue to add 50-80 mass parts of G2-8NH 2 ...

Embodiment 3

[0088] Obtaining or preparing branched macromolecular compounds (first component raw materials):

[0089] 1. Six-armed polyethylene glycol carboxylic acid, the average molecular weight is about 10,000 Daltons, with 6 branched chains, and the molecular structure is as follows Figure 7 As shown, purchased from Xiamen Sinobanger Biotechnology Co., Ltd.

[0090] 2. Eight-armed polyethylene glycol carboxylic acid, the average molecular weight is about 20,000 Daltons, with 8 branched chains, and the molecular structure is as follows Figure 8 As shown, purchased from Xiamen Sinobanger Biotechnology Co., Ltd.

[0091] 3. The preparation process of soluble pullulan:

[0092] (1) Dissolving 50-100 parts by mass of pullulan (CAS number: 9037-22-3) in 1000 parts by mass of purified water to form a pullulan suspension;

[0093] (2) Adjust the pH value of the pullulan suspension to 1.5 to 2.5, and the solution is continuously degraded for 12 to 48 hours at a temperature of 40°C to 60°C...

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Abstract

The invention proposes a two-component cross-linked medical composite material, its preparation method and application, including a first component and a second component, the first component is a recombinant polymer compound terminated by an active group, and the active group The capped recombinant macromolecular compound is formed by chemical bonding between the branched compound capped by the active group and the branched macromolecular compound or the linear macromolecular compound. , and the end of each branch has one and only one active group, and the second component is a biocompatible polysaccharide cross-linking agent. The two-component cross-linked medical composite material of the present invention has a three-dimensional space network structure, which can be instantly and rapidly formed on the wound surface of the mucous membrane or skin, can be seamlessly connected with the wound surface, seals and protects the wound surface, and has the function of preventing tissue adhesion at the same time. Connectivity, the material backs to the wound surface is smooth and non-adhesive, and the surrounding adjacent tissues or foreign objects cannot adhere to the wound surface.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a two-component cross-linked medical composite material, its preparation method and application. Background technique [0002] Hydrogel is the first biomaterial developed for use in the human body. It exhibits good biocompatibility when in contact with blood, body fluids, and human tissues. It does not affect the metabolic process of living organisms and allows metabolites to pass through. The hydrogel is expelled. However, hydrogels have problems such as rapid swelling and adhesion. US Patent 2006 / 0078536 discloses a hydrogel tissue adhesive produced by reacting an oxidized polysaccharide with a multi-armed polyetheramine. The elongation at break of the hydrogel is improved by reducing the crosslink density of the hydrogel, however, since crosslinking can prevent swelling of the hydrogel and enhance the strength of the hydrogel, a lower crosslink density will The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/24C08L87/00C08L3/10C08L3/04C08L5/02C08L3/02C08L5/08A61L27/60A61L27/50A61L27/26
CPCA61L27/26A61L27/50A61L27/60C08J3/24C08J2387/00C08J2403/02C08J2403/04C08J2403/10C08J2405/02C08J2405/08C08L87/00C08L3/10C08L3/04C08L5/02C08L3/02C08L5/08
Inventor 吴建华姚江平
Owner 杭州仪文生物医药有限公司