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A method for preparing α-tricalcium phosphate based on inositol molecule and its application

A technology of tricalcium phosphate and amorphous calcium phosphate, which is applied in the fields of materials science and biomedicine, can solve problems affecting product effects, and achieve the effects of shortening the preparation cycle, reducing energy consumption, and low energy consumption

Active Publication Date: 2021-12-21
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It has been reported in the literature that low-temperature calcination of amorphous calcium phosphate with a calcium-phosphorus ratio of 1.5 obtains an α / β phase mixture, but how to stably obtain a pure α phase is still unknown. The inventors have found in long-term experiments that the state of the precursor amorphous calcium phosphate Greatly affected the effect of subsequent products

Method used

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  • A method for preparing α-tricalcium phosphate based on inositol molecule and its application
  • A method for preparing α-tricalcium phosphate based on inositol molecule and its application
  • A method for preparing α-tricalcium phosphate based on inositol molecule and its application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1) Accurately prepare 0.4mol / L Ca(NO 3 ) 2 Solution 200ml (solution A), and 0.266mol / L (NH 4 ) 2 HPO 4 Solution 200ml (Solution B).

[0060] 2) Add 2 g of inositol to solution A under 28°C water heating and magnetic stirring, stir for 30 minutes to obtain a uniform solution, then add ammonia water dropwise to raise the pH to 10.2-10.5, and then use a separatory funnel to dissolve Solution B was added dropwise to solution A, and the pH of the mixture was kept between 10.2 and 10.5 during the process. The dropwise addition was completed after 40 minutes, and stirring was continued for 30 minutes.

[0061] 3) Suction filter the above solution, wash the original solution three times with water and absolute ethanol after the suction filtration, then air-dry at room temperature (28°C) for 6 to 8 hours, then coarsely grind the dried particles in a mortar, and then Carry out calcination, the calcination treatment conditions are: heating rate 10°C / min, calcination temperat...

Embodiment 2

[0064] 1) Accurately prepare 0.4mol / L Ca(NO 3 ) 2 Solution 200ml (solution A), and 0.266mol / L (NH 4 ) 2 HPO 4 Solution 200ml (Solution B).

[0065] 2) Add 2 g of inositol to solution A under 28°C water heating and magnetic stirring, stir for 30 minutes to obtain a uniform solution, then add ammonia water dropwise to raise the pH to 10.2-10.5, and then use a separatory funnel to dissolve Solution B was added dropwise to solution A, and the pH of the mixture was kept between 10.2 and 10.5 during the process. The dropwise addition was completed after 40 minutes, and stirring was continued for 30 minutes.

[0066] 3) Suction filter the above solution, wash the original solution three times with water and absolute ethanol after the suction filtration, then air-dry at room temperature (28°C) for 6 to 8 hours, then coarsely grind the dried particles in a mortar, and then Carry out calcination, and the calcination treatment conditions are: heating rate 10°C / min, calcination temp...

Embodiment 3

[0069] 1) Accurately prepare 0.4mol / L Ca(NO 3 ) 2 Solution 200ml (solution A), and 0.266mol / L (NH 4 ) 2 HPO 4 Solution 200ml (Solution N).

[0070] 2) Add 2 g of inositol to solution A under 28°C water heating and magnetic stirring, stir for 30 minutes to obtain a uniform solution, then add ammonia water dropwise to raise the pH to 10.2-10.5, and then use a separatory funnel to dissolve Solution B was added dropwise to solution A, and the pH of the mixture was kept between 10.2 and 10.5 during the process. The dropwise addition was completed after 40 minutes, and stirring was continued for 30 minutes.

[0071] 3) Suction filter the above solution, wash the original solution three times with water and absolute ethanol after the suction filtration, then air-dry at room temperature (28°C) for 6 to 8 hours, then coarsely grind the dried particles in a mortar, and then Carry out calcination, the calcination treatment conditions are: heating rate 10°C / min, calcination temperat...

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Abstract

The invention provides a method for preparing α-tricalcium phosphate based on inositol molecules and its application, belonging to the technical fields of material science and biomedicine. The invention promotes the directional transformation of amorphous calcium phosphate into α-tricalcium phosphate when the phase transition temperature is lower than the phase transition temperature through precipitation reaction of inositol-containing calcium salt solution and phosphate solution at a specific pH value and subsequent low-temperature calcination. Compared with the traditional preparation process of high-temperature solid-state reaction followed by rapid cooling, this method has simple equipment, low energy consumption, effectively avoids grain coarsening caused by high-temperature calcination, and realizes nano-scale α-tricalcium phosphate powder under low-temperature calcination rapid mass production. The prepared powder has good crystallinity and uniform particle size, is an ideal raw material for calcium phosphate bone cement, and therefore has good practical application prospects.

Description

technical field [0001] The invention belongs to the technical fields of material science and biomedicine, and specifically relates to a method for preparing alpha-tricalcium phosphate based on inositol molecules and its application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Calcium phosphate bone cement, because of its good biocompatibility, osteoconductive and osteoinductive properties, has attracted extensive attention from researchers, and has broad application prospects in the fields of bone replacement and drug delivery. Among them, compared with brushite bone cement, which needs to be hardened under acidic conditions, apatite bone cement shows excellent curing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32C04B12/02
CPCC01B25/32C04B12/025C01P2002/72
Inventor 毕见强王璐孙康宁李爱民袁震毛俊杰
Owner SHANDONG UNIV
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