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Method for preparing idebebone and microcrystalline cellulose composite carrier and cosmetic

A technology of microcrystalline cellulose and idebenone, applied in cosmetics, cosmetic preparations, medical preparations containing active ingredients, etc., can solve the problems of difficult loading and release, achieve excellent biological safety, reduce Irritant, good biocompatibility effects

Pending Publication Date: 2020-11-24
HUNAN YUJIA COSMETICS MFG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for some water-insoluble active substances, it is difficult to achieve efficient loading and release only by physical adsorption.

Method used

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  • Method for preparing idebebone and microcrystalline cellulose composite carrier and cosmetic
  • Method for preparing idebebone and microcrystalline cellulose composite carrier and cosmetic
  • Method for preparing idebebone and microcrystalline cellulose composite carrier and cosmetic

Examples

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preparation example Construction

[0035] The invention provides a preparation method of idebenone and microcrystalline cellulose composite carrier, comprising the following steps:

[0036] Step 1, taking microcrystalline cellulose powder and dispersing it in an aqueous solution to form a suspension containing microcrystalline cellulose particles;

[0037] Specifically, the microcrystalline cellulose powder is dispersed in an aqueous solution using ultrasonic waves, the mass concentration of the microcrystalline cellulose is 1%-5%, and shear dispersion is performed at 300rpm-500rpm to form a uniform suspension.

[0038] Step 2. Add oleic acid ethanol solution dropwise to the suspension, stir and mix the surface of microcrystalline cellulose particles with oleic acid, wash and centrifuge to obtain oleic acid-coated microcrystalline cellulose particles;

[0039] Specifically, the suspension needs to be heated to 60°C, and then 0.5%-2% by mass percentage of oleic acid ethanol solution is added dropwise, stirred fo...

Embodiment 1

[0044] The microcrystalline cellulose particle of embodiment 1 oleic acid modification

[0045] 1) Weigh three solid microcrystalline cellulose powders (MCC-20, MCC-90, MCC-250) with different particle sizes, and disperse them in the aqueous solution so that the final mass concentration is between 5%, ultrasonically disperse Finally, shear and disperse at 300rpm-500rpm to form a uniform suspension.

[0046] 2) Heat the suspension to 60°C, add 2% mass percent oleic acid ethanol solution (volume ratio 1:1), and add it dropwise to the suspension, stir for 1 hour, and wash with deionized water after adsorption equilibrium The obtained oleic acid-modified microcrystalline cellulose particles were collected by centrifugation after repeated 5 times and dried.

[0047] Microcrystalline cellulose itself has a certain adsorption capacity. By introducing oleic acid, oleic acid can be adsorbed and combined with the surface of microcrystalline cellulose, thereby forming microcrystalline ...

Embodiment 2

[0056] Determination of adsorption capacity of microcrystalline cellulose microparticles modified by embodiment 2 oleic acid

[0057] 1) Select 20 micron microcrystalline cellulose MCC-20 as the carrier, disperse it in the aqueous solution so that the final mass concentration is between 5%, after ultrasonic dispersion, shear and disperse at 300rpm-500rpm to form a uniform suspension;

[0058] 2) Heating the suspension to 60°C, adding 2% mass percent oleic acid ethanol solution (volume ratio 1:1), and adding it dropwise to the microcrystalline cellulose suspension, and stirring for 1 hour. After adsorption equilibrium, the obtained oleic acid-modified microcrystalline cellulose particles were washed with deionized water, repeated 5 times, collected by centrifugation and dried;

[0059] 3) Disperse the oleic acid-modified particles in an ethanol solution, introduce idebenone at 10 mg / mL, load for 72 hours, and centrifuge and dry to obtain the idebenone / microcrystalline cellulos...

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Abstract

The invention discloses a method for preparing an idebebone and microcrystalline cellulose composite carrier. The method comprises the following steps: weighing microcrystalline cellulose powder, anddispersing the microcrystalline cellulose powder in an aqueous solution, so as to form a suspension containing microcrystalline cellulose microparticles; dropwise adding an ethanol solution of oleic acid into the suspension, carrying out stirring and mixing, then, subjecting the microcrystalline cellulose microparticles to surface oleic acid wrapping, and carrying out centrifuge washing, so as toobtain oleic-acid-wrapped microcrystalline cellulose microparticles; and dispersing the obtained microcrystalline cellulose microparticles in an ethanol solution, introducing idebebone for compounding, and carrying out centrifugal drying, thereby obtaining the idebebone and microcrystalline cellulose composite carrier. The invention further provides a cosmetic. The method has the following advantages that sustained slow release of the idebebone is achieved, and thus, potential irritation is effectively lowered; and meanwhile, particles are simple in preparation process, have good biocompatibility, can be excellently applied to external application products for skin and are suitable for being produced in an enlarged manner.

Description

【Technical field】 [0001] The invention relates to the technical field of cosmetics, in particular to a preparation method of a composite carrier of idebenone and microcrystalline cellulose and cosmetics. 【Background technique】 [0002] The chemical name of idebenone is 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone, its structure is similar to coenzyme Q10, and it is a molecular weight The lower CoQ10 short-chain branched structure analogue has been clinically used to repair photoaging skin. In the field of cosmetics, idebenone has good antioxidant effect, can scavenge free radicals, inhibit mitochondrial production of lipid peroxide, inhibit inflammation, inhibit DNA damage, protect against light damage, reduce pigmentation, etc. Studies have found that the use of idebenone can improve skin fine lines and roughness, improve skin elasticity, color and brightness, and is an ideal cosmetic active substance. [0003] However, idebenone has a small molecular weigh...

Claims

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Application Information

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IPC IPC(8): A61K8/35A61K8/73A61K8/36A61Q19/08
CPCA61K8/355A61K8/731A61K8/361A61Q19/08A61K2800/82A61K2800/412A61K2800/56A61K2800/522
Inventor 戴跃锋何广文马晓瑜颜少慰
Owner HUNAN YUJIA COSMETICS MFG CO LTD
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