Hydrogel for inflammatory resistance and repair and preparation method of hydrogel

A hydrogel, anti-inflammatory technology, applied in medical science, bandages, etc., can solve the problems of difficult-to-moisture necrotic tissue, waste of use cost, poor liquid delivery performance, etc., to improve liquid absorption and liquid delivery performance, and promote autolysis. Debridement and healing effect

Active Publication Date: 2020-11-24
WINNER MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional hydrogels have good fluid absorption performance, but poor fluid delivery performance, making it difficult to provide more water to the wound, soften necrotic tissue more quickly, and achieve autolytic debridement
Moreover, in addition to the basic function of absorbing and supplying liquid, it cannot solve the problems of inflammation caused by scabs and rot, etc. For the inflammation on the wound,

Method used

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  • Hydrogel for inflammatory resistance and repair and preparation method of hydrogel
  • Hydrogel for inflammatory resistance and repair and preparation method of hydrogel
  • Hydrogel for inflammatory resistance and repair and preparation method of hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Influence of Compound Selection of Gel Matrix on Liquid Affinity

[0029] This test mainly measures the liquid absorption and liquid delivery properties of hydrogels by measuring the amount of liquid absorbed from agar and the amount of liquid delivered to gelatin. Agar simulated a lightly exuding wound, and gelatin simulated a dry, scabbed wound.

[0030] The hydrogels were prepared according to the following recipe.

[0031]

[0032] The preparation process is as follows:

[0033] S1. Soak the acrylic / C10-30 alkanol acrylate crosslinked polymer with an appropriate amount of deionized water and set aside;

[0034] S2. Mix and disperse carboxymethylcellulose, hydroxyethylcellulose and glycerin respectively, and set aside;

[0035] S3. Add an appropriate amount of deionized water into the reaction kettle, heat it to 65-75°C, add the pre-dispersed raw materials for S1 and S2, and after stirring, homogenizing, and vacuum defoaming, the product is in a uniform state; ...

Embodiment 2

[0061] Effects of compounding of antiseptic system on antiseptic performance and cytotoxicity

[0062] The hydrogels were prepared according to the following recipe.

[0063]

[0064]

[0065] The preparation process is the same as in Example 1.

[0066] Anti-corrosion performance test:

[0067] Test method: Refer to the United States Pharmacopoeia USP42-NF37, 2019, chapter 51 for antiseptic efficacy test.

[0068] Test bacteria: Bacteria: Escherichia coli (ATCC No.8739); Staphylococcus aureus (ATCC No.6538); Pseudomonas aeruginosa (ATCC No.9027); Fungi: Candida albicans (ATCC No.10231); Mold (ATCC No. 16404).

[0069] Judging criteria: bacteria: the logarithmic value of the number of bacteria from the initial day to 14 days cannot be less than 2.0, and the number of bacteria cannot increase from day 14 to day 28; fungi: the number of fungi cannot increase from day 14 to day 28.

[0070] test results:

[0071] Total number of bacteria (CFU / gram)

[0072] ...

Embodiment 3

[0090] The repairing effect of functional additives on skin damage and evaluation of anti-inflammatory efficacy

[0091] The hydrogels were prepared according to the following recipe.

[0092]

[0093]

[0094] The preparation process is the same as in Example 1.

[0095] Skin damage repair test:

[0096] experimental method:

[0097] 1. Solution preparation:

[0098] LPS (lipopolysaccharide): use serum-free 1640 culture medium to prepare a mother solution with a concentration of 500,000 / mL, filter and sterilize with a 0.22 μm filter membrane, store in a -20°C refrigerator, and dilute to a working solution of 10,000 / mL before use.

[0099] Hydrogel solution: Prepare a 5% experimental sample with LPS working solution, filter and sterilize with a 0.22 μm filter membrane, and store in a refrigerator at -20°C.

[0100] 2. Dosing treatment

[0101] Seed Raw264.7 cells in a 24-well plate at 1*105 / mL at 37°C, 5% CO 2 Cultivate for 24 hours under the same conditions, add s...

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Abstract

The invention belongs to the technical field of gel, and discloses hydrogel for inflammatory resistance and repair. The hydrogel comprises the following components in parts by weight: 0.01-0.5 part ofan acrylic acid (ester) cross-linked polymer, 0.1-3 parts of carboxymethyl cellulose, 0.1-4 parts of hydroxyethyl cellulose, 1-20 parts of a humectant, 0.05-0.5 part of allantoin, 1-10 parts of schizophyllan, 1-10 parts of scleroglucan, 0.1-3 parts of tetrahydromethylpyrimidine carboxylic acid, 0.5-3 parts of glucolactone, 0.2-2 parts of sodium benzoate, 0.05-1 part of a pH regulator and 43-95 parts of deionized water. The invention also discloses a preparation method of the hydrogel. The hydrogel disclosed by the invention is improved in the aspects of product use mode, biocompatibility, liquid absorption, liquid feeding property, moisturizing, -inflammation resistance, repairing and the like, and the defects of a traditional product in wound nursing are overcome, so that a patient can obtain a better experience feeling in the nursing process, and wound healing is promoted more quickly.

Description

technical field [0001] The invention belongs to the technical field of gels, in particular to an anti-inflammatory repairing hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a kind of soft material containing a large amount of water obtained by cross-linking hydrophilic polymers. Hydrogels have excellent physical and chemical properties and biological properties, such as high water content, high elasticity, softness, and biocompatibility, and have important application values ​​in biomedical fields such as drug delivery and tissue engineering. [0003] The main purpose of the hydrogel product is to soften the wound tissue by providing more moisture to the wound, so as to achieve the effect of autolytic debridement, so that some scabs and carrion of the wound can be removed more easily, and at the same time, it can provide more Moisture to soothe wounds and relieve pain. Traditional hydrogels have good liquid absorption performance, but p...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0066A61L26/0023A61L26/0014A61L26/0061A61L26/00A61L2300/412A61L2300/41A61L2300/232A61L2300/204C08L1/286C08L1/284C08L5/02C08L33/08
Inventor 李建全胡秀萍王欢
Owner WINNER MEDICAL CO LTD
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