Mitochondria targeted external medicinal preparation

Abstract

The invention discloses a mitochondria targeted external medicinal preparation which comprises a drug, a drug carrier and an auxiliary material. The drug carrier is mitochondria targeted phospholipid,and a hydrophilic head part of the phospholipid is connected with (3-propyl carboxyl) triphenylphosphine, arginine, lysine or dendritic polypeptide molecules consisting of arginine and / or lysine through an amido bond or an ester bond. Drug-loaded lipidosome prepared from the drug carrier carries positive charges, is easy to take in by cells, and can be targeted to mitochondria under the drive ofa transmembrane potential, so that the drug is released and gradually gathered in the mitochondria, and the drug effect can be further taken in the mitochondria.

Description

technical field

[0001] The invention belongs to the field of drug delivery systems, and relates to a mitochondria-targeted external drug preparation, which is suitable for skin care and prevention and treatment of skin diseases. Background technique

[0002] The skin is the largest organ of the human body. As the first physiological defense line of the human body, it is always involved in the functional activities of the body and maintains the unity of opposites between the body and the natural environment. The application of external preparations is mostly divided into two categories, one is the treatment of skin diseases, and the other is daily skin care. At present, the commonly used transdermal preparations often have two major defects, (1) the transdermal performance of the preparation is poor, and the drug stays more on the surface of the skin to affect the final drug effect; (2) the drug lacks intracellular secondary targeting , can not play a role in a specific site...

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