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Crosslinked polymer and preparation method thereof, drug carrier and biomedical implant material

A technology of cross-linked polymers and compounds, applied in drug delivery, medical preparations of non-active ingredients, prostheses, etc., can solve problems such as poor lubrication effect, and achieve the effect of improving stability and good cell compatibility

Active Publication Date: 2020-12-15
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Based on this, it is necessary to provide a cross-linked polymer and its preparation method, drug carrier and biomedical implant material for the problems of biomedical implant resistance to bacteria and poor lubricating effect

Method used

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  • Crosslinked polymer and preparation method thereof, drug carrier and biomedical implant material
  • Crosslinked polymer and preparation method thereof, drug carrier and biomedical implant material
  • Crosslinked polymer and preparation method thereof, drug carrier and biomedical implant material

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preparation example Construction

[0050] The embodiment of the present invention also provides a preparation method of the cross-linked polymer of any of the above embodiments, including making the first monomer represented by the general formula (5), the second monomer represented by the general formula (6) and the general formula The step in which the third monomer represented by (7) undergoes a polymerization reaction.

[0051]

[0052] In some embodiments, the step of preparing the first monomer is: reacting dopamine hydrochloride with a double bond-containing compound under basic conditions. The double bond-containing compound may be selected from any one or both of methacrylic anhydride and glycerol methacrylate.

[0053] In some embodiments, the preparation step of the second monomer is: reacting 6-amino-β-cyclodextrin with a double bond-containing compound. The double bond-containing compound may be selected from any one or both of methacrylic anhydride and glycerol methacrylate.

[0054] In some ...

Embodiment 1

[0063] Synthesis of dopamine methacrylamide (DMA):

[0064] (1) Weigh 10g of dopamine hydrochloride in a 500mL flask, add 20mL of ultrapure water to dissolve the solid and stop the bottle with a rubber stopper in time. The weighing and dissolution process should be as fast as possible, then add 20g of sodium borate and 8g of sodium bicarbonate As a catalyst, magnetically stir the solid to dissolve;

[0065] (2) Measure 9.4mL of methacrylic anhydride, add 50mL of tetrahydrofuran (THF) and stir evenly;

[0066] (3) Under the condition of stirring, the above-mentioned THF solution is added dropwise to the dopamine hydrochloride phase through the constant pressure dropping funnel, then the pH of the solution is adjusted to 8.5 with the NaOH solution of 0.2mol / L, and the reaction is carried out under N 2 Stir continuously for 12h under atmosphere;

[0067] (4) Adjust the pH of the reacted solution to below 2 with 0.2mol / L dilute hydrochloric acid solution to obtain a mud-colored ...

Embodiment 2

[0081] Synthesis of dopamine containing double bonds:

[0082] (1) Weigh 10g of dopamine hydrochloride in a 500mL flask, add 20mL of ultrapure water to dissolve the solid and stop the bottle with a rubber stopper in time. The weighing and dissolution process should be as fast as possible, then add 20g of sodium borate and 8g of sodium bicarbonate As a catalyst, magnetically stir the solid to dissolve;

[0083] (2) Measure 7.5g of glyceryl methacrylate, add 50mL of tetrahydrofuran (THF) and stir evenly;

[0084] (3) Under the condition of stirring, the above-mentioned THF solution is added dropwise to the dopamine hydrochloride phase through the constant pressure dropping funnel, then the pH of the solution is adjusted to 8.5 with the NaOH solution of 0.2mol / L, and the reaction is carried out under N 2 Stir continuously for 12h under atmosphere;

[0085](4) Adjust the pH of the reacted solution to below 2 with 0.2mol / L dilute hydrochloric acid solution to obtain a mud-colored...

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Abstract

Disclosed is a crosslinked polymer comprising a first repeating unit represented by general formula (1), a second repeating unit represented by general formula (2), and a third repeating unit represented by general formula (3). The invention also discloses a preparation method of the cross-linked polymer. The invention also discloses a preparation method of the cross-linked polymer. The inventionalso discloses a drug carrier. The invention also discloses a biomedical implant material.

Description

technical field [0001] The invention relates to the technical field of functional materials, in particular to a cross-linked polymer and a preparation method thereof, a drug carrier and a biomedical implant material. Background technique [0002] In recent years, with the rapid development of biomedicine, biomaterials and tissue engineering, titanium-based biomedical implants have been widely used in dentistry and orthopedics due to their excellent biocompatibility, osteoconductivity and mechanical properties. In treatment. However, due to their lack of antibacterial ability, titanium-based biomedical implants are highly susceptible to viral infections. In addition, implants with poor lubricating properties can lead to damage to human soft tissues, which in turn leads to a series of continuous complications. [0003] However, few previous studies have well combined the antibacterial and lubricating properties of biomedical implants. For example, the surface of biomedical ...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F220/58C08F230/02C08F220/36A61K47/69A61L27/06A61L27/34A61L27/50A61L27/54
CPCC08F251/00A61K47/6951A61L27/06A61L27/34A61L27/50A61L27/54A61L2400/10A61L2430/02A61L2430/12A61L2300/602A61L2300/406C08F220/58C08F230/02C08F220/36C08L51/02
Inventor 张洪玉王海蟒韩英
Owner TSINGHUA UNIV
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